miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease

Several micro RNAs have been shown to be deregulated in brain tissue or sera from individuals with Alzheimer’s disease and in AD mouse models. The authors show that miR-135a-5p is downregulated in excitatory pyramidal neurons from AD mice and that dysfunction of miR-135a-5p/Rock2/Add1 results in mem...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Kai Zheng, Fan Hu, Yang Zhou, Juan Zhang, Jie Zheng, Chuan Lai, Wan Xiong, Ke Cui, Ya-Zhuo Hu, Zhi-Tao Han, Hong-Hong Zhang, Jian-Guo Chen, Heng-Ye Man, Dan Liu, Youming Lu, Ling-Qiang Zhu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3366a3bed29948729d65876a46ebc7a7
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:3366a3bed29948729d65876a46ebc7a7
record_format	dspace
spelling	oai:doaj.org-article:3366a3bed29948729d65876a46ebc7a72021-12-02T17:04:30ZmiR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease10.1038/s41467-021-22196-y2041-1723https://doaj.org/article/3366a3bed29948729d65876a46ebc7a72021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-22196-yhttps://doaj.org/toc/2041-1723Several micro RNAs have been shown to be deregulated in brain tissue or sera from individuals with Alzheimer’s disease and in AD mouse models. The authors show that miR-135a-5p is downregulated in excitatory pyramidal neurons from AD mice and that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in AD.Kai ZhengFan HuYang ZhouJuan ZhangJie ZhengChuan LaiWan XiongKe CuiYa-Zhuo HuZhi-Tao HanHong-Hong ZhangJian-Guo ChenHeng-Ye ManDan LiuYouming LuLing-Qiang ZhuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kai Zheng Fan Hu Yang Zhou Juan Zhang Jie Zheng Chuan Lai Wan Xiong Ke Cui Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Guo Chen Heng-Ye Man Dan Liu Youming Lu Ling-Qiang Zhu miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
description	Several micro RNAs have been shown to be deregulated in brain tissue or sera from individuals with Alzheimer’s disease and in AD mouse models. The authors show that miR-135a-5p is downregulated in excitatory pyramidal neurons from AD mice and that dysfunction of miR-135a-5p/Rock2/Add1 results in memory/synaptic disorder in AD.
format	article
author	Kai Zheng Fan Hu Yang Zhou Juan Zhang Jie Zheng Chuan Lai Wan Xiong Ke Cui Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Guo Chen Heng-Ye Man Dan Liu Youming Lu Ling-Qiang Zhu
author_facet	Kai Zheng Fan Hu Yang Zhou Juan Zhang Jie Zheng Chuan Lai Wan Xiong Ke Cui Ya-Zhuo Hu Zhi-Tao Han Hong-Hong Zhang Jian-Guo Chen Heng-Ye Man Dan Liu Youming Lu Ling-Qiang Zhu
author_sort	Kai Zheng
title	miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
title_short	miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
title_full	miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
title_fullStr	miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
title_full_unstemmed	miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease
title_sort	mir-135a-5p mediates memory and synaptic impairments via the rock2/adducin1 signaling pathway in a mouse model of alzheimer’s disease
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3366a3bed29948729d65876a46ebc7a7
work_keys_str_mv	AT kaizheng mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT fanhu mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT yangzhou mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT juanzhang mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT jiezheng mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT chuanlai mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT wanxiong mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT kecui mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT yazhuohu mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT zhitaohan mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT honghongzhang mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT jianguochen mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT hengyeman mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT danliu mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT youminglu mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease AT lingqiangzhu mir135a5pmediatesmemoryandsynapticimpairmentsviatherock2adducin1signalingpathwayinamousemodelofalzheimersdisease
_version_	1718381839702294528

miR-135a-5p mediates memory and synaptic impairments via the Rock2/Adducin1 signaling pathway in a mouse model of Alzheimer’s disease

Ejemplares similares