Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions

LncRNAs regulate gene expression via their RNA product and through transcriptional interference. Here, Stojic et al.uncouple these functions by using multiple siRNAs against GNG12-AS1 to show that this lncRNA has a product related role in MET signaling while its transcription modulates DIRAS3 expres...

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Autores principales:	Lovorka Stojic, Malwina Niemczyk, Arturo Orjalo, Yoko Ito, Anna Elisabeth Maria Ruijter, Santiago Uribe-Lewis, Nimesh Joseph, Stephen Weston, Suraj Menon, Duncan T. Odom, John Rinn, Fanni Gergely, Adele Murrell
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/3369c8d0029843a985e6ea32ac2d1c39
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spelling	oai:doaj.org-article:3369c8d0029843a985e6ea32ac2d1c392021-12-02T14:38:33ZTranscriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions10.1038/ncomms104062041-1723https://doaj.org/article/3369c8d0029843a985e6ea32ac2d1c392016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10406https://doaj.org/toc/2041-1723LncRNAs regulate gene expression via their RNA product and through transcriptional interference. Here, Stojic et al.uncouple these functions by using multiple siRNAs against GNG12-AS1 to show that this lncRNA has a product related role in MET signaling while its transcription modulates DIRAS3 expression.Lovorka StojicMalwina NiemczykArturo OrjaloYoko ItoAnna Elisabeth Maria RuijterSantiago Uribe-LewisNimesh JosephStephen WestonSuraj MenonDuncan T. OdomJohn RinnFanni GergelyAdele MurrellNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lovorka Stojic Malwina Niemczyk Arturo Orjalo Yoko Ito Anna Elisabeth Maria Ruijter Santiago Uribe-Lewis Nimesh Joseph Stephen Weston Suraj Menon Duncan T. Odom John Rinn Fanni Gergely Adele Murrell Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
description	LncRNAs regulate gene expression via their RNA product and through transcriptional interference. Here, Stojic et al.uncouple these functions by using multiple siRNAs against GNG12-AS1 to show that this lncRNA has a product related role in MET signaling while its transcription modulates DIRAS3 expression.
format	article
author	Lovorka Stojic Malwina Niemczyk Arturo Orjalo Yoko Ito Anna Elisabeth Maria Ruijter Santiago Uribe-Lewis Nimesh Joseph Stephen Weston Suraj Menon Duncan T. Odom John Rinn Fanni Gergely Adele Murrell
author_facet	Lovorka Stojic Malwina Niemczyk Arturo Orjalo Yoko Ito Anna Elisabeth Maria Ruijter Santiago Uribe-Lewis Nimesh Joseph Stephen Weston Suraj Menon Duncan T. Odom John Rinn Fanni Gergely Adele Murrell
author_sort	Lovorka Stojic
title	Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
title_short	Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
title_full	Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
title_fullStr	Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
title_full_unstemmed	Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions
title_sort	transcriptional silencing of long noncoding rna gng12-as1 uncouples its transcriptional and product-related functions
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/3369c8d0029843a985e6ea32ac2d1c39
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Transcriptional silencing of long noncoding RNA GNG12-AS1 uncouples its transcriptional and product-related functions

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