Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer

Na Qu,1 Robert J Lee,1,2 Yating Sun,1 Guangsheng Cai,1 Junyang Wang,1 Mengqiao Wang,1 Jiahui Lu,1 Qingfan Meng,1 Lirong Teng,1 Di Wang,1 Lesheng Teng1,3 1School of Life Sciences, Jilin University, Changchun, People’s Republic of China; 2Division of Pharmaceutics, College of Pharmacy, The...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Qu N, Lee RJ, Sun Y, Cai G, Wang J, Wang M, Lu J, Meng Q, Teng L, Wang D
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2016
Materias:	cabazitaxel human serum albumin nanoparticle drug delivery toxicity prostate cancer Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/33700a83902b4e429e6f14c11189f8f9
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:33700a83902b4e429e6f14c11189f8f9
record_format	dspace
spelling	oai:doaj.org-article:33700a83902b4e429e6f14c11189f8f92021-12-02T02:01:48ZCabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer1178-2013https://doaj.org/article/33700a83902b4e429e6f14c11189f8f92016-07-01T00:00:00Zhttps://www.dovepress.com/cabazitaxel-loaded-human-serum-albumin-nanoparticles-as-a-therapeutic--peer-reviewed-article-IJNhttps://doaj.org/toc/1178-2013Na Qu,1 Robert J Lee,1,2 Yating Sun,1 Guangsheng Cai,1 Junyang Wang,1 Mengqiao Wang,1 Jiahui Lu,1 Qingfan Meng,1 Lirong Teng,1 Di Wang,1 Lesheng Teng1,3 1School of Life Sciences, Jilin University, Changchun, People’s Republic of China; 2Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA; 3State Key Laboratory of Long-acting and Targeting Drug Delivery System, Yantai, People’s Republic of China Abstract: Cabazitaxel-loaded human serum albumin nanoparticles (Cbz-NPs) were synthesized to overcome vehicle-related toxicity of current clinical formulation of the drug based on Tween-80 (Cbz-Tween). A salting-out method was used for NP synthesis that avoids the use of chlorinated organic solvent and is simpler compared to the methods based on emulsion-solvent evaporation. Cbz-NPs had a narrow particle size distribution, suitable drug loading content (4.9%), and superior blood biocompatibility based on in vitro hemolysis assay. Blood circulation, tumor uptake, and antitumor activity of Cbz-NPs were assessed in prostatic cancer xenograft-bearing nude mice. Cbz-NPs exhibited prolonged blood circulation and greater accumulation of Cbz in tumors along with reduced toxicity compared to Cbz-Tween. Moreover, hematoxylin and eosin histopathological staining of organs revealed consistent results. The levels of blood urea nitrogen and serum creatinine in drug-treated mice showed that Cbz-NPs were less toxic than Cbz-Tween to the kidneys. In conclusion, Cbz-NPs provide a promising therapeutic for prostate cancer. Keywords: cabazitaxel, human serum albumin, nanoparticle, drug delivery, toxicity, prostate cancerQu NLee RJSun YCai GWang JWang MLu JMeng QTeng LWang DTeng LDove Medical Pressarticlecabazitaxelhuman serum albuminnanoparticledrug deliverytoxicityprostate cancerMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2016, Iss default, Pp 3451-3459 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	cabazitaxel human serum albumin nanoparticle drug delivery toxicity prostate cancer Medicine (General) R5-920
spellingShingle	cabazitaxel human serum albumin nanoparticle drug delivery toxicity prostate cancer Medicine (General) R5-920 Qu N Lee RJ Sun Y Cai G Wang J Wang M Lu J Meng Q Teng L Wang D Teng L Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer
description	Na Qu,1 Robert J Lee,1,2 Yating Sun,1 Guangsheng Cai,1 Junyang Wang,1 Mengqiao Wang,1 Jiahui Lu,1 Qingfan Meng,1 Lirong Teng,1 Di Wang,1 Lesheng Teng1,3 1School of Life Sciences, Jilin University, Changchun, People’s Republic of China; 2Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, OH, USA; 3State Key Laboratory of Long-acting and Targeting Drug Delivery System, Yantai, People’s Republic of China Abstract: Cabazitaxel-loaded human serum albumin nanoparticles (Cbz-NPs) were synthesized to overcome vehicle-related toxicity of current clinical formulation of the drug based on Tween-80 (Cbz-Tween). A salting-out method was used for NP synthesis that avoids the use of chlorinated organic solvent and is simpler compared to the methods based on emulsion-solvent evaporation. Cbz-NPs had a narrow particle size distribution, suitable drug loading content (4.9%), and superior blood biocompatibility based on in vitro hemolysis assay. Blood circulation, tumor uptake, and antitumor activity of Cbz-NPs were assessed in prostatic cancer xenograft-bearing nude mice. Cbz-NPs exhibited prolonged blood circulation and greater accumulation of Cbz in tumors along with reduced toxicity compared to Cbz-Tween. Moreover, hematoxylin and eosin histopathological staining of organs revealed consistent results. The levels of blood urea nitrogen and serum creatinine in drug-treated mice showed that Cbz-NPs were less toxic than Cbz-Tween to the kidneys. In conclusion, Cbz-NPs provide a promising therapeutic for prostate cancer. Keywords: cabazitaxel, human serum albumin, nanoparticle, drug delivery, toxicity, prostate cancer
format	article
author	Qu N Lee RJ Sun Y Cai G Wang J Wang M Lu J Meng Q Teng L Wang D Teng L
author_facet	Qu N Lee RJ Sun Y Cai G Wang J Wang M Lu J Meng Q Teng L Wang D Teng L
author_sort	Qu N
title	Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer
title_short	Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer
title_full	Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer
title_fullStr	Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer
title_full_unstemmed	Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer
title_sort	cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer
publisher	Dove Medical Press
publishDate	2016
url	https://doaj.org/article/33700a83902b4e429e6f14c11189f8f9
work_keys_str_mv	AT qun cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer AT leerj cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer AT suny cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer AT caig cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer AT wangj cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer AT wangm cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer AT luj cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer AT mengq cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer AT tengl cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer AT wangd cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer AT tengl cabazitaxelloadedhumanserumalbuminnanoparticlesasatherapeuticagentagainstprostatecancer
_version_	1718402766764769280

Cabazitaxel-loaded human serum albumin nanoparticles as a therapeutic agent against prostate cancer

Ejemplares similares