Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China
Abstract Background Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high...
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2021
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oai:doaj.org-article:33749efb74ad44b5ad4329f2287928512021-11-21T12:28:48ZInfection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China10.1186/s40249-021-00918-02049-9957https://doaj.org/article/33749efb74ad44b5ad4329f2287928512021-11-01T00:00:00Zhttps://doi.org/10.1186/s40249-021-00918-0https://doaj.org/toc/2049-9957Abstract Background Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region. Methods A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates. Results Totally 886 individuals were recruited. The baseline seroprevalence that was tested before the epidemic season was 11.9% (70/587) for IgG and 6.8% (40/587) for NAb, which was increased to 13.4% (47/350) and 7.7% (27/350) during the epidemic season, and further to 15.8% (80/508) and 9.8% (50/508) post epidemic. The IgG antibody-based seropositivity was significantly related to the patients aged ≥ 70 years old [adjusted odds ratio (OR) = 2.440, 95% confidence interval (CI): 1.334–4.461 compared to the group of < 50 years old, P = 0.004], recent contact with cats (adjusted OR = 2.195, 95% CI: 1.261–3.818, P = 0.005), and working in tea garden (adjusted OR = 1.698, 95% CI: 1.002–2.880, P = 0.049) by applying multivariate logistic regression model. The NAb based seropositivity was similarly related to the patients aged ≥ 70 years old (adjusted OR = 2.691, 95% CI: 1.271–5.695 compared to the group of < 50 years old, P = 0.010), and recent contact with cats (OR = 2.648, 95% CI: 1.419–4.941, P = 0.002). For a cohort of individuals continually sampled with 1-year apart, the anti-SFTSV IgG were maintained at a stable level, while the NAb level reduced. Conclusions Subclinical infection might not provide adequate immunity to protect reinfection of SFTSV, thus highlighting the ongoing threats of SFTS in endemic regions, which called for an imperative need for vaccine development. Identification of risk factors might help to target high-risk population for public health education and vaccination in the future. Graphical AbstractXiao-Lei YeKe DaiQing-Bin LuYan-Qin HuangShou-Ming LvPan-He ZhangJia-Chen LiHai-Yang ZhangZhen-Dong YangNing CuiChun YuanKun LiuXiao-Ai ZhangJiu-Song ZhangHao LiYang YangLi-Qun FangWei LiuBMCarticleSevere fever with thrombocytopeniaSerological studyHealthy participantIgG antibodyNeutralizing antibodyInfectious and parasitic diseasesRC109-216Public aspects of medicineRA1-1270ENInfectious Diseases of Poverty, Vol 10, Iss 1, Pp 1-9 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Severe fever with thrombocytopenia Serological study Healthy participant IgG antibody Neutralizing antibody Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 |
| spellingShingle |
Severe fever with thrombocytopenia Serological study Healthy participant IgG antibody Neutralizing antibody Infectious and parasitic diseases RC109-216 Public aspects of medicine RA1-1270 Xiao-Lei Ye Ke Dai Qing-Bin Lu Yan-Qin Huang Shou-Ming Lv Pan-He Zhang Jia-Chen Li Hai-Yang Zhang Zhen-Dong Yang Ning Cui Chun Yuan Kun Liu Xiao-Ai Zhang Jiu-Song Zhang Hao Li Yang Yang Li-Qun Fang Wei Liu Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China |
| description |
Abstract Background Severe fever with thrombocytopenia (SFTS) caused by SFTS virus (SFTSV) was a tick-borne hemorrhagic fever that posed significant threat to human health in Eastern Asia. The study was designed to measure the seroprevalence of SFTSV antibody in healthy population residing in a high endemic region. Methods A cohort study was performed on healthy residents in Shangcheng County in Xinyang City from April to December in 2018, where the highest SFTS incidence in China was reported. Anti-SFTSV IgG was measured by indirect enzyme-linked immunosorbent assay and neutralizing antibody (NAb) was detected by using PRNT50. The logistic regression models were performed to analyze the variables that were associated with seropositive rates. Results Totally 886 individuals were recruited. The baseline seroprevalence that was tested before the epidemic season was 11.9% (70/587) for IgG and 6.8% (40/587) for NAb, which was increased to 13.4% (47/350) and 7.7% (27/350) during the epidemic season, and further to 15.8% (80/508) and 9.8% (50/508) post epidemic. The IgG antibody-based seropositivity was significantly related to the patients aged ≥ 70 years old [adjusted odds ratio (OR) = 2.440, 95% confidence interval (CI): 1.334–4.461 compared to the group of < 50 years old, P = 0.004], recent contact with cats (adjusted OR = 2.195, 95% CI: 1.261–3.818, P = 0.005), and working in tea garden (adjusted OR = 1.698, 95% CI: 1.002–2.880, P = 0.049) by applying multivariate logistic regression model. The NAb based seropositivity was similarly related to the patients aged ≥ 70 years old (adjusted OR = 2.691, 95% CI: 1.271–5.695 compared to the group of < 50 years old, P = 0.010), and recent contact with cats (OR = 2.648, 95% CI: 1.419–4.941, P = 0.002). For a cohort of individuals continually sampled with 1-year apart, the anti-SFTSV IgG were maintained at a stable level, while the NAb level reduced. Conclusions Subclinical infection might not provide adequate immunity to protect reinfection of SFTSV, thus highlighting the ongoing threats of SFTS in endemic regions, which called for an imperative need for vaccine development. Identification of risk factors might help to target high-risk population for public health education and vaccination in the future. Graphical Abstract |
| format |
article |
| author |
Xiao-Lei Ye Ke Dai Qing-Bin Lu Yan-Qin Huang Shou-Ming Lv Pan-He Zhang Jia-Chen Li Hai-Yang Zhang Zhen-Dong Yang Ning Cui Chun Yuan Kun Liu Xiao-Ai Zhang Jiu-Song Zhang Hao Li Yang Yang Li-Qun Fang Wei Liu |
| author_facet |
Xiao-Lei Ye Ke Dai Qing-Bin Lu Yan-Qin Huang Shou-Ming Lv Pan-He Zhang Jia-Chen Li Hai-Yang Zhang Zhen-Dong Yang Ning Cui Chun Yuan Kun Liu Xiao-Ai Zhang Jiu-Song Zhang Hao Li Yang Yang Li-Qun Fang Wei Liu |
| author_sort |
Xiao-Lei Ye |
| title |
Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China |
| title_short |
Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China |
| title_full |
Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China |
| title_fullStr |
Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China |
| title_full_unstemmed |
Infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, China |
| title_sort |
infection with severe fever with thrombocytopenia virus in healthy population: a cohort study in a high endemic region, china |
| publisher |
BMC |
| publishDate |
2021 |
| url |
https://doaj.org/article/33749efb74ad44b5ad4329f228792851 |
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