Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes

Dixing Liu, Jiana Zhong, Weiheng Wen, Yuting Ruan, Zhen Zhang, Jia Sun, Hong Chen Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Hong Chen; Jia SunDepartment of Endocrinology, Zhujiang Hospital, Southern Me...

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Autores principales:	Liu D, Zhong J, Wen W, Ruan Y, Zhang Z, Sun J, Chen H
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	type 2 diabetes mellitus cardiovascular diseases skeletal muscle mass to visceral fat area ratio risk assessment Specialties of internal medicine RC581-951
Acceso en línea:	https://doaj.org/article/3379e0246a8645a8b837cbeb2fe0e0c2
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spelling	oai:doaj.org-article:3379e0246a8645a8b837cbeb2fe0e0c22021-12-02T16:46:28ZRelationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes1178-7007https://doaj.org/article/3379e0246a8645a8b837cbeb2fe0e0c22021-08-01T00:00:00Zhttps://www.dovepress.com/relationship-between-skeletal-muscle-mass-to-visceral-fat-area-ratio-a-peer-reviewed-fulltext-article-DMSOhttps://doaj.org/toc/1178-7007Dixing Liu, Jiana Zhong, Weiheng Wen, Yuting Ruan, Zhen Zhang, Jia Sun, Hong Chen Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Hong Chen; Jia SunDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue, Guangzhou, Guangdong, 510282, People’s Republic of ChinaTel +86 13602759769; +86 13751822925Email chenhong123@smu.edu.cn; sunjia@smu.edu.cnPurpose: Either visceral fat or muscle mass is identified to be correlated with cardiometabolic diseases, especially in type 2 diabetes (T2DM). But, the synergistical effect of visceral fat along with skeletal muscle on the risk of cardiovascular diseases (CVD) in T2DM still remains controversial. Thus, we investigated the relationship between skeletal muscle mass to visceral fat area ratio (SVR) and 10-yr CVD risk scores.Patients and Methods: A total of 291 T2DM patients aged 40– 80 years were enrolled in the current study. SVR was evaluated based on bioelectrical impedance measurements. Both Framingham risk score system and China-PAR risk model were applied to estimate future 10-yr CVD risk in T2DM population.Results: The 10-yr CVD risk scores increased with the decreased SVR tertiles in T2DM (All P< 0.001). SVR value was obviously lower in the high-risk group than that of low- or moderate-risk group (All P< 0.05). However, no significant differences were observed in BMI among different CVD risk groups. Besides, SVR was correlated with Framingham risk score (r=− 0.408; P< 0.001) and China-PAR risk score (r=− 0.336; P< 0.001). HOMA-IR, triglycerides and blood pressure were also inversely related to SVR (All P< 0.05). Furthermore, SVR value was independently correlated with both Framingham 10-yr CVD risk score (β=− 0.074, P=0.047) and China-PAR risk score (β=− 0.100, P=0.004) after adjustment for confounding factors, including age, gender, BMI, FPG, HbA1c, diabetes duration, albumin, creatinine, uric acid, smoking, blood pressure and blood lipid. The linear regression analysis was also conducted for men and women, respectively, indicating that the negative relationship between SVR and 10-yr CVD risk was observed in men but not in women.Conclusion: T2DM populations who have lower SVR value are more likely to increase CVD risk. SVR levels show marked and inverse correlation with estimated 10-yr CVD risk in T2DM, indicating that SVR could be a valuable parameter to assess the risk of CVD events in clinical practice, especially in men.Keywords: type 2 diabetes mellitus, cardiovascular diseases, skeletal muscle mass to visceral fat area ratio, risk assessmentLiu DZhong JWen WRuan YZhang ZSun JChen HDove Medical Pressarticletype 2 diabetes mellituscardiovascular diseasesskeletal muscle mass to visceral fat area ratiorisk assessmentSpecialties of internal medicineRC581-951ENDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy, Vol Volume 14, Pp 3733-3742 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	type 2 diabetes mellitus cardiovascular diseases skeletal muscle mass to visceral fat area ratio risk assessment Specialties of internal medicine RC581-951
spellingShingle	type 2 diabetes mellitus cardiovascular diseases skeletal muscle mass to visceral fat area ratio risk assessment Specialties of internal medicine RC581-951 Liu D Zhong J Wen W Ruan Y Zhang Z Sun J Chen H Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes
description	Dixing Liu, Jiana Zhong, Weiheng Wen, Yuting Ruan, Zhen Zhang, Jia Sun, Hong Chen Department of Endocrinology, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, People’s Republic of ChinaCorrespondence: Hong Chen; Jia SunDepartment of Endocrinology, Zhujiang Hospital, Southern Medical University, 253 Industrial Avenue, Guangzhou, Guangdong, 510282, People’s Republic of ChinaTel +86 13602759769; +86 13751822925Email chenhong123@smu.edu.cn; sunjia@smu.edu.cnPurpose: Either visceral fat or muscle mass is identified to be correlated with cardiometabolic diseases, especially in type 2 diabetes (T2DM). But, the synergistical effect of visceral fat along with skeletal muscle on the risk of cardiovascular diseases (CVD) in T2DM still remains controversial. Thus, we investigated the relationship between skeletal muscle mass to visceral fat area ratio (SVR) and 10-yr CVD risk scores.Patients and Methods: A total of 291 T2DM patients aged 40– 80 years were enrolled in the current study. SVR was evaluated based on bioelectrical impedance measurements. Both Framingham risk score system and China-PAR risk model were applied to estimate future 10-yr CVD risk in T2DM population.Results: The 10-yr CVD risk scores increased with the decreased SVR tertiles in T2DM (All P< 0.001). SVR value was obviously lower in the high-risk group than that of low- or moderate-risk group (All P< 0.05). However, no significant differences were observed in BMI among different CVD risk groups. Besides, SVR was correlated with Framingham risk score (r=− 0.408; P< 0.001) and China-PAR risk score (r=− 0.336; P< 0.001). HOMA-IR, triglycerides and blood pressure were also inversely related to SVR (All P< 0.05). Furthermore, SVR value was independently correlated with both Framingham 10-yr CVD risk score (β=− 0.074, P=0.047) and China-PAR risk score (β=− 0.100, P=0.004) after adjustment for confounding factors, including age, gender, BMI, FPG, HbA1c, diabetes duration, albumin, creatinine, uric acid, smoking, blood pressure and blood lipid. The linear regression analysis was also conducted for men and women, respectively, indicating that the negative relationship between SVR and 10-yr CVD risk was observed in men but not in women.Conclusion: T2DM populations who have lower SVR value are more likely to increase CVD risk. SVR levels show marked and inverse correlation with estimated 10-yr CVD risk in T2DM, indicating that SVR could be a valuable parameter to assess the risk of CVD events in clinical practice, especially in men.Keywords: type 2 diabetes mellitus, cardiovascular diseases, skeletal muscle mass to visceral fat area ratio, risk assessment
format	article
author	Liu D Zhong J Wen W Ruan Y Zhang Z Sun J Chen H
author_facet	Liu D Zhong J Wen W Ruan Y Zhang Z Sun J Chen H
author_sort	Liu D
title	Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes
title_short	Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes
title_full	Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes
title_fullStr	Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes
title_full_unstemmed	Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes
title_sort	relationship between skeletal muscle mass to visceral fat area ratio and cardiovascular risk in type 2 diabetes
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/3379e0246a8645a8b837cbeb2fe0e0c2
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Relationship Between Skeletal Muscle Mass to Visceral Fat Area Ratio and Cardiovascular Risk in Type 2 Diabetes

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