EXPRESSION OF IMMUNOCORRECTIVE EFFECTS OF PHENOTROPIL AT DIFFERENT TERMS OF INDUCED IMMUNOSUPPRESSION

Abstract. In present work, an immunocorrective effect of phenotropil after intraperitoneal injection (50 mg/kgx3) was studied in CBA mice. The drug was administered either before antigenic stimulation, and/or cyclophosphamide-induced immunosuppression, or at the terms of evolving immune deficiency....

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Autores principales:	M. A. Samotrueva, I. N. Tyurenkov, D. L. Teplyi, S. A. Luzhnova, M. M. Magomedov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	immunosuppression cyclophosphamide phenotropil immunocorrection Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/337b296fd7014b1795afe9085c5943c4
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spelling	oai:doaj.org-article:337b296fd7014b1795afe9085c5943c42021-11-18T08:03:40ZEXPRESSION OF IMMUNOCORRECTIVE EFFECTS OF PHENOTROPIL AT DIFFERENT TERMS OF INDUCED IMMUNOSUPPRESSION1563-06252313-741X10.15789/1563-0625-2009-6-567-570https://doaj.org/article/337b296fd7014b1795afe9085c5943c42014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/369https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. In present work, an immunocorrective effect of phenotropil after intraperitoneal injection (50 mg/kgx3) was studied in CBA mice. The drug was administered either before antigenic stimulation, and/or cyclophosphamide-induced immunosuppression, or at the terms of evolving immune deficiency. Phenotropil was shown to prevent the development of immune pathology which manifested as inhibition at all steps of immunogenesis, thus suggesting a preventive potential of its immunocorrective properties.M. A. SamotruevaI. N. TyurenkovD. L. TeplyiS. A. LuzhnovaM. M. MagomedovSPb RAACIarticleimmunosuppressioncyclophosphamidephenotropilimmunocorrectionImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 11, Iss 6, Pp 567-570 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	immunosuppression cyclophosphamide phenotropil immunocorrection Immunologic diseases. Allergy RC581-607
spellingShingle	immunosuppression cyclophosphamide phenotropil immunocorrection Immunologic diseases. Allergy RC581-607 M. A. Samotrueva I. N. Tyurenkov D. L. Teplyi S. A. Luzhnova M. M. Magomedov EXPRESSION OF IMMUNOCORRECTIVE EFFECTS OF PHENOTROPIL AT DIFFERENT TERMS OF INDUCED IMMUNOSUPPRESSION
description	Abstract. In present work, an immunocorrective effect of phenotropil after intraperitoneal injection (50 mg/kgx3) was studied in CBA mice. The drug was administered either before antigenic stimulation, and/or cyclophosphamide-induced immunosuppression, or at the terms of evolving immune deficiency. Phenotropil was shown to prevent the development of immune pathology which manifested as inhibition at all steps of immunogenesis, thus suggesting a preventive potential of its immunocorrective properties.
format	article
author	M. A. Samotrueva I. N. Tyurenkov D. L. Teplyi S. A. Luzhnova M. M. Magomedov
author_facet	M. A. Samotrueva I. N. Tyurenkov D. L. Teplyi S. A. Luzhnova M. M. Magomedov
author_sort	M. A. Samotrueva
title	EXPRESSION OF IMMUNOCORRECTIVE EFFECTS OF PHENOTROPIL AT DIFFERENT TERMS OF INDUCED IMMUNOSUPPRESSION
title_short	EXPRESSION OF IMMUNOCORRECTIVE EFFECTS OF PHENOTROPIL AT DIFFERENT TERMS OF INDUCED IMMUNOSUPPRESSION
title_full	EXPRESSION OF IMMUNOCORRECTIVE EFFECTS OF PHENOTROPIL AT DIFFERENT TERMS OF INDUCED IMMUNOSUPPRESSION
title_fullStr	EXPRESSION OF IMMUNOCORRECTIVE EFFECTS OF PHENOTROPIL AT DIFFERENT TERMS OF INDUCED IMMUNOSUPPRESSION
title_full_unstemmed	EXPRESSION OF IMMUNOCORRECTIVE EFFECTS OF PHENOTROPIL AT DIFFERENT TERMS OF INDUCED IMMUNOSUPPRESSION
title_sort	expression of immunocorrective effects of phenotropil at different terms of induced immunosuppression
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/337b296fd7014b1795afe9085c5943c4
work_keys_str_mv	AT masamotrueva expressionofimmunocorrectiveeffectsofphenotropilatdifferenttermsofinducedimmunosuppression AT intyurenkov expressionofimmunocorrectiveeffectsofphenotropilatdifferenttermsofinducedimmunosuppression AT dlteplyi expressionofimmunocorrectiveeffectsofphenotropilatdifferenttermsofinducedimmunosuppression AT saluzhnova expressionofimmunocorrectiveeffectsofphenotropilatdifferenttermsofinducedimmunosuppression AT mmmagomedov expressionofimmunocorrectiveeffectsofphenotropilatdifferenttermsofinducedimmunosuppression
_version_	1718422534644301824

EXPRESSION OF IMMUNOCORRECTIVE EFFECTS OF PHENOTROPIL AT DIFFERENT TERMS OF INDUCED IMMUNOSUPPRESSION

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