Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus
ABSTRACT Even within similar bacterial strains, it has been found that the clustered, regularly interspaced short palindromic repeat (CRISPR) shows a large variability of spacers. Modeling bacterial strains with different levels of immunity to infection by a single virulent phage, we find that coexi...
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| Autores principales: | , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
American Society for Microbiology
2012
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/337d3e09defd4ee99c3644f73be2b826 |
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| Sumario: | ABSTRACT Even within similar bacterial strains, it has been found that the clustered, regularly interspaced short palindromic repeat (CRISPR) shows a large variability of spacers. Modeling bacterial strains with different levels of immunity to infection by a single virulent phage, we find that coexistence in a well-mixed environment is possible only when these levels are distinctly different. When bacterial strains are similar, one subpopulation collapses. In the case of bacteria with various levels of CRISPR immunity to a range of phages, small differences in spacer composition will accordingly be suppressed under well-mixed conditions. Using a numerical model of populations spreading in space, we predict that it is the Lamarckian nature of CRISPR evolution that combines with spatial correlations to sustain the experimentally observed distribution of spacer diversity. |
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