Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus

ABSTRACT Even within similar bacterial strains, it has been found that the clustered, regularly interspaced short palindromic repeat (CRISPR) shows a large variability of spacers. Modeling bacterial strains with different levels of immunity to infection by a single virulent phage, we find that coexi...

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Autores principales:	Jan O. Haerter, Kim Sneppen
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2012
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/337d3e09defd4ee99c3644f73be2b826
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spelling	oai:doaj.org-article:337d3e09defd4ee99c3644f73be2b8262021-11-15T15:39:10ZSpatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus10.1128/mBio.00126-122150-7511https://doaj.org/article/337d3e09defd4ee99c3644f73be2b8262012-08-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.00126-12https://doaj.org/toc/2150-7511ABSTRACT Even within similar bacterial strains, it has been found that the clustered, regularly interspaced short palindromic repeat (CRISPR) shows a large variability of spacers. Modeling bacterial strains with different levels of immunity to infection by a single virulent phage, we find that coexistence in a well-mixed environment is possible only when these levels are distinctly different. When bacterial strains are similar, one subpopulation collapses. In the case of bacteria with various levels of CRISPR immunity to a range of phages, small differences in spacer composition will accordingly be suppressed under well-mixed conditions. Using a numerical model of populations spreading in space, we predict that it is the Lamarckian nature of CRISPR evolution that combines with spatial correlations to sustain the experimentally observed distribution of spacer diversity.Jan O. HaerterKim SneppenAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 3, Iss 4 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Jan O. Haerter Kim Sneppen Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus
description	ABSTRACT Even within similar bacterial strains, it has been found that the clustered, regularly interspaced short palindromic repeat (CRISPR) shows a large variability of spacers. Modeling bacterial strains with different levels of immunity to infection by a single virulent phage, we find that coexistence in a well-mixed environment is possible only when these levels are distinctly different. When bacterial strains are similar, one subpopulation collapses. In the case of bacteria with various levels of CRISPR immunity to a range of phages, small differences in spacer composition will accordingly be suppressed under well-mixed conditions. Using a numerical model of populations spreading in space, we predict that it is the Lamarckian nature of CRISPR evolution that combines with spatial correlations to sustain the experimentally observed distribution of spacer diversity.
format	article
author	Jan O. Haerter Kim Sneppen
author_facet	Jan O. Haerter Kim Sneppen
author_sort	Jan O. Haerter
title	Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus
title_short	Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus
title_full	Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus
title_fullStr	Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus
title_full_unstemmed	Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus
title_sort	spatial structure and lamarckian adaptation explain extreme genetic diversity at crispr locus
publisher	American Society for Microbiology
publishDate	2012
url	https://doaj.org/article/337d3e09defd4ee99c3644f73be2b826
work_keys_str_mv	AT janohaerter spatialstructureandlamarckianadaptationexplainextremegeneticdiversityatcrisprlocus AT kimsneppen spatialstructureandlamarckianadaptationexplainextremegeneticdiversityatcrisprlocus
_version_	1718427756937609216

Spatial Structure and Lamarckian Adaptation Explain Extreme Genetic Diversity at CRISPR Locus

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