Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides

Liquid-liquid phase separation (LLPS) of intrinsically disordered proteins plays an important part in the formation of extracellular biological materials. Here, the authors show that repeats of the peptide motif GHGLY are necessary for the LLPS of pH-responsive histidine-rich squid beak proteins.

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Autores principales:	Bartosz Gabryelczyk, Hao Cai, Xiangyan Shi, Yue Sun, Piet J. M. Swinkels, Stefan Salentinig, Konstantin Pervushin, Ali Miserez
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/337dc093694a4439bf2180dfd333f834
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spelling	oai:doaj.org-article:337dc093694a4439bf2180dfd333f8342021-12-02T16:58:28ZHydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides10.1038/s41467-019-13469-82041-1723https://doaj.org/article/337dc093694a4439bf2180dfd333f8342019-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13469-8https://doaj.org/toc/2041-1723Liquid-liquid phase separation (LLPS) of intrinsically disordered proteins plays an important part in the formation of extracellular biological materials. Here, the authors show that repeats of the peptide motif GHGLY are necessary for the LLPS of pH-responsive histidine-rich squid beak proteins.Bartosz GabryelczykHao CaiXiangyan ShiYue SunPiet J. M. SwinkelsStefan SalentinigKonstantin PervushinAli MiserezNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bartosz Gabryelczyk Hao Cai Xiangyan Shi Yue Sun Piet J. M. Swinkels Stefan Salentinig Konstantin Pervushin Ali Miserez Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides
description	Liquid-liquid phase separation (LLPS) of intrinsically disordered proteins plays an important part in the formation of extracellular biological materials. Here, the authors show that repeats of the peptide motif GHGLY are necessary for the LLPS of pH-responsive histidine-rich squid beak proteins.
format	article
author	Bartosz Gabryelczyk Hao Cai Xiangyan Shi Yue Sun Piet J. M. Swinkels Stefan Salentinig Konstantin Pervushin Ali Miserez
author_facet	Bartosz Gabryelczyk Hao Cai Xiangyan Shi Yue Sun Piet J. M. Swinkels Stefan Salentinig Konstantin Pervushin Ali Miserez
author_sort	Bartosz Gabryelczyk
title	Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides
title_short	Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides
title_full	Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides
title_fullStr	Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides
title_full_unstemmed	Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides
title_sort	hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/337dc093694a4439bf2180dfd333f834
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Hydrogen bond guidance and aromatic stacking drive liquid-liquid phase separation of intrinsically disordered histidine-rich peptides

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