Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis

Fariborz Ghaffarpasand,1 Saeed Torabi,2 Ali Rasti,3 Mohammad Hadi Niakan,4 Sara Aghabaklou,5 Fatemeh Pakzad,6 Maryam Sadat Beheshtian,7 Reza Tabrizi8 1Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Anesthesiology and Intensive Care...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Ghaffarpasand F, Torabi S, Rasti A, Niakan MH, Aghabaklou S, Pakzad F, Beheshtian MS, Tabrizi R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Traumatic brain injury (TBI) Cerebrolysin Functional Outcome Glasgow coma scale (GOS) Modified Rankin Scale (mRS) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/337e2a001434446396f9518cb7e85528
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:337e2a001434446396f9518cb7e85528
record_format	dspace
institution	DOAJ
collection	DOAJ
language	EN
topic	Traumatic brain injury (TBI) Cerebrolysin Functional Outcome Glasgow coma scale (GOS) Modified Rankin Scale (mRS) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Traumatic brain injury (TBI) Cerebrolysin Functional Outcome Glasgow coma scale (GOS) Modified Rankin Scale (mRS) Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Ghaffarpasand F Torabi S Rasti A Niakan MH Aghabaklou S Pakzad F Beheshtian MS Tabrizi R Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis
description	Fariborz Ghaffarpasand,1 Saeed Torabi,2 Ali Rasti,3 Mohammad Hadi Niakan,4 Sara Aghabaklou,5 Fatemeh Pakzad,6 Maryam Sadat Beheshtian,7 Reza Tabrizi8 1Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany; 3Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 4Trauma Research Center, Rajaei Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; 5Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran; 7Department of Neurosurgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 8Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Background: Traumatic brain injury (TBI) remains a main public health problem being associated with high mortality and morbidity. The functional outcome of TBI remains unfavorable despite several surgical and medical therapies. Cerebrolysin is a neuropeptide with potential neuroregenerative entities. Objective: The aim of the current systematic review and meta-analysis was to investigate the effects of cerebrolysin on functional outcome in patients with moderate and severe TBI. Data sources: Online databases used included Medline, Scopus, EMBASE, Google Scholar, Web of Science, and Cochrane Library. Study eligibility criteria: All the relevant studies with randomized clinical trial and cohort design evaluating the effects of intravenous cerebrolysin vs placebo on functional outcome of patients with TBI within the English literature up to October 2018 were included. Study appraisal and synthesis methods: The articles were reviewed by two independent authors and the data were extracted to a data sheet. I2 and Cochran’s Q-statistics were used to assess heterogeneity. Based on the presence of significant heterogeneity across included studies, data were pooled using random-effects model with Dersimonian–Laird method and presented as standardized mean differences (SMDs) and corresponding 95% CI. Results: Five articles (5,685 participants) were included in the current meta-analysis. The overall pooled findings using random-effects models among patients with TBI indicated that intravenous administration of cerebrolysin significantly increased Glasgow Outcome Scale score (SMD =0.30; 95% CI: 0.18 to 0.42; P<0.001; I2: 87.8%) and decreased modified Rankin Scale score (SMD =-0.29; 95% CI: -0.42 to 0.16; P=0.05; I2: 89.6%). Limitations: The results are mainly based on cohort studies and there is a lack of clinical trials in the literature. There is also heterogeneity among the studies regarding the dosage and duration of administration and the measurement of functional outcome. Conclusion: The results of the current study revealed that intravenous administration of cerebrolysin is associated with improved functional outcome in patients with TBI measured by the Glasgow Outcome Scale and the modified Rankin Scale scores. Keywords: traumatic brain injury, TBI, cerebrolysin, functional outcome, Glasgow Coma Scale, GOS, modified Rankin Scale, mRS
format	article
author	Ghaffarpasand F Torabi S Rasti A Niakan MH Aghabaklou S Pakzad F Beheshtian MS Tabrizi R
author_facet	Ghaffarpasand F Torabi S Rasti A Niakan MH Aghabaklou S Pakzad F Beheshtian MS Tabrizi R
author_sort	Ghaffarpasand F
title	Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis
title_short	Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis
title_full	Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis
title_fullStr	Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis
title_full_unstemmed	Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis
title_sort	effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/337e2a001434446396f9518cb7e85528
work_keys_str_mv	AT ghaffarpasandf effectsofcerebrolysinonfunctionaloutcomeofpatientswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT torabis effectsofcerebrolysinonfunctionaloutcomeofpatientswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT rastia effectsofcerebrolysinonfunctionaloutcomeofpatientswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT niakanmh effectsofcerebrolysinonfunctionaloutcomeofpatientswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT aghabaklous effectsofcerebrolysinonfunctionaloutcomeofpatientswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT pakzadf effectsofcerebrolysinonfunctionaloutcomeofpatientswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT beheshtianms effectsofcerebrolysinonfunctionaloutcomeofpatientswithtraumaticbraininjuryasystematicreviewandmetaanalysis AT tabrizir effectsofcerebrolysinonfunctionaloutcomeofpatientswithtraumaticbraininjuryasystematicreviewandmetaanalysis
_version_	1718402032038051840
spelling	oai:doaj.org-article:337e2a001434446396f9518cb7e855282021-12-02T02:55:52ZEffects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis1178-2021https://doaj.org/article/337e2a001434446396f9518cb7e855282018-12-01T00:00:00Zhttps://www.dovepress.com/effects-of-cerebrolysin-on-functional-outcome-of-patients-with-traumat-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Fariborz Ghaffarpasand,1 Saeed Torabi,2 Ali Rasti,3 Mohammad Hadi Niakan,4 Sara Aghabaklou,5 Fatemeh Pakzad,6 Maryam Sadat Beheshtian,7 Reza Tabrizi8 1Research Center for Neuromodulation and Pain, Shiraz University of Medical Sciences, Shiraz, Iran; 2Department of Anesthesiology and Intensive Care Medicine, University Hospital of Cologne, Cologne, Germany; 3Poostchi Ophthalmology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; 4Trauma Research Center, Rajaei Trauma Hospital, Shiraz University of Medical Sciences, Shiraz, Iran; 5Department of Neurosurgery, Tehran University of Medical Sciences, Tehran, Iran; 6Department of Anesthesiology, Shiraz University of Medical Sciences, Shiraz, Iran; 7Department of Neurosurgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 8Health Policy Research Center, Institute of Health, Student Research Committee, Shiraz University of Medical Sciences, Shiraz, Iran Background: Traumatic brain injury (TBI) remains a main public health problem being associated with high mortality and morbidity. The functional outcome of TBI remains unfavorable despite several surgical and medical therapies. Cerebrolysin is a neuropeptide with potential neuroregenerative entities. Objective: The aim of the current systematic review and meta-analysis was to investigate the effects of cerebrolysin on functional outcome in patients with moderate and severe TBI. Data sources: Online databases used included Medline, Scopus, EMBASE, Google Scholar, Web of Science, and Cochrane Library. Study eligibility criteria: All the relevant studies with randomized clinical trial and cohort design evaluating the effects of intravenous cerebrolysin vs placebo on functional outcome of patients with TBI within the English literature up to October 2018 were included. Study appraisal and synthesis methods: The articles were reviewed by two independent authors and the data were extracted to a data sheet. I2 and Cochran’s Q-statistics were used to assess heterogeneity. Based on the presence of significant heterogeneity across included studies, data were pooled using random-effects model with Dersimonian–Laird method and presented as standardized mean differences (SMDs) and corresponding 95% CI. Results: Five articles (5,685 participants) were included in the current meta-analysis. The overall pooled findings using random-effects models among patients with TBI indicated that intravenous administration of cerebrolysin significantly increased Glasgow Outcome Scale score (SMD =0.30; 95% CI: 0.18 to 0.42; P<0.001; I2: 87.8%) and decreased modified Rankin Scale score (SMD =-0.29; 95% CI: -0.42 to 0.16; P=0.05; I2: 89.6%). Limitations: The results are mainly based on cohort studies and there is a lack of clinical trials in the literature. There is also heterogeneity among the studies regarding the dosage and duration of administration and the measurement of functional outcome. Conclusion: The results of the current study revealed that intravenous administration of cerebrolysin is associated with improved functional outcome in patients with TBI measured by the Glasgow Outcome Scale and the modified Rankin Scale scores. Keywords: traumatic brain injury, TBI, cerebrolysin, functional outcome, Glasgow Coma Scale, GOS, modified Rankin Scale, mRSGhaffarpasand FTorabi SRasti ANiakan MHAghabaklou SPakzad FBeheshtian MSTabrizi RDove Medical PressarticleTraumatic brain injury (TBI)CerebrolysinFunctional OutcomeGlasgow coma scale (GOS)Modified Rankin Scale (mRS)Neurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 127-135 (2018)

Effects of cerebrolysin on functional outcome of patients with traumatic brain injury: a systematic review and meta-analysis

Ejemplares similares