YAP-independent mechanotransduction drives breast cancer progression

The transcriptional regulator YAP is regarded as the universal mechanotransducer, largely from 2D culture studies. Here the authors show that in breast cancer patient tissues and cells in 3D culture, mechanical signals are transduced independently of YAP, questioning YAP as a therapeutic target.

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Autores principales:	Joanna Y. Lee, Jessica K. Chang, Antonia A. Dominguez, Hong-pyo Lee, Sungmin Nam, Julie Chang, Sushama Varma, Lei S. Qi, Robert B. West, Ovijit Chaudhuri
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/337f109f64fc4a38a5a3689ef568e48a
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spelling	oai:doaj.org-article:337f109f64fc4a38a5a3689ef568e48a2021-12-02T16:57:50ZYAP-independent mechanotransduction drives breast cancer progression10.1038/s41467-019-09755-02041-1723https://doaj.org/article/337f109f64fc4a38a5a3689ef568e48a2019-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-09755-0https://doaj.org/toc/2041-1723The transcriptional regulator YAP is regarded as the universal mechanotransducer, largely from 2D culture studies. Here the authors show that in breast cancer patient tissues and cells in 3D culture, mechanical signals are transduced independently of YAP, questioning YAP as a therapeutic target.Joanna Y. LeeJessica K. ChangAntonia A. DominguezHong-pyo LeeSungmin NamJulie ChangSushama VarmaLei S. QiRobert B. WestOvijit ChaudhuriNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-9 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joanna Y. Lee Jessica K. Chang Antonia A. Dominguez Hong-pyo Lee Sungmin Nam Julie Chang Sushama Varma Lei S. Qi Robert B. West Ovijit Chaudhuri YAP-independent mechanotransduction drives breast cancer progression
description	The transcriptional regulator YAP is regarded as the universal mechanotransducer, largely from 2D culture studies. Here the authors show that in breast cancer patient tissues and cells in 3D culture, mechanical signals are transduced independently of YAP, questioning YAP as a therapeutic target.
format	article
author	Joanna Y. Lee Jessica K. Chang Antonia A. Dominguez Hong-pyo Lee Sungmin Nam Julie Chang Sushama Varma Lei S. Qi Robert B. West Ovijit Chaudhuri
author_facet	Joanna Y. Lee Jessica K. Chang Antonia A. Dominguez Hong-pyo Lee Sungmin Nam Julie Chang Sushama Varma Lei S. Qi Robert B. West Ovijit Chaudhuri
author_sort	Joanna Y. Lee
title	YAP-independent mechanotransduction drives breast cancer progression
title_short	YAP-independent mechanotransduction drives breast cancer progression
title_full	YAP-independent mechanotransduction drives breast cancer progression
title_fullStr	YAP-independent mechanotransduction drives breast cancer progression
title_full_unstemmed	YAP-independent mechanotransduction drives breast cancer progression
title_sort	yap-independent mechanotransduction drives breast cancer progression
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/337f109f64fc4a38a5a3689ef568e48a
work_keys_str_mv	AT joannaylee yapindependentmechanotransductiondrivesbreastcancerprogression AT jessicakchang yapindependentmechanotransductiondrivesbreastcancerprogression AT antoniaadominguez yapindependentmechanotransductiondrivesbreastcancerprogression AT hongpyolee yapindependentmechanotransductiondrivesbreastcancerprogression AT sungminnam yapindependentmechanotransductiondrivesbreastcancerprogression AT juliechang yapindependentmechanotransductiondrivesbreastcancerprogression AT sushamavarma yapindependentmechanotransductiondrivesbreastcancerprogression AT leisqi yapindependentmechanotransductiondrivesbreastcancerprogression AT robertbwest yapindependentmechanotransductiondrivesbreastcancerprogression AT ovijitchaudhuri yapindependentmechanotransductiondrivesbreastcancerprogression
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YAP-independent mechanotransduction drives breast cancer progression

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