pH-dependent and dynamic interactions of cystatin C with heparan sulfate

Zhang et al. identify Cystatin C as a new heparan sulfate (HS) binding protein, however only at acidic pH (≤6.5). They further identify two isolated HS binding motifs on Cystatin C that are required to come together to form a complete HS-binding site, which is a unique property among known HS bindin...

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Autores principales:	Xiaoxiao Zhang, Xinyue Liu, Guowei Su, Miaomiao Li, Jian Liu, Chunyu Wang, Ding Xu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/338128b64475457ebc8664996dc93af2
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spelling	oai:doaj.org-article:338128b64475457ebc8664996dc93af22021-12-02T14:26:46ZpH-dependent and dynamic interactions of cystatin C with heparan sulfate10.1038/s42003-021-01737-72399-3642https://doaj.org/article/338128b64475457ebc8664996dc93af22021-02-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-01737-7https://doaj.org/toc/2399-3642Zhang et al. identify Cystatin C as a new heparan sulfate (HS) binding protein, however only at acidic pH (≤6.5). They further identify two isolated HS binding motifs on Cystatin C that are required to come together to form a complete HS-binding site, which is a unique property among known HS binding proteins.Xiaoxiao ZhangXinyue LiuGuowei SuMiaomiao LiJian LiuChunyu WangDing XuNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Xiaoxiao Zhang Xinyue Liu Guowei Su Miaomiao Li Jian Liu Chunyu Wang Ding Xu pH-dependent and dynamic interactions of cystatin C with heparan sulfate
description	Zhang et al. identify Cystatin C as a new heparan sulfate (HS) binding protein, however only at acidic pH (≤6.5). They further identify two isolated HS binding motifs on Cystatin C that are required to come together to form a complete HS-binding site, which is a unique property among known HS binding proteins.
format	article
author	Xiaoxiao Zhang Xinyue Liu Guowei Su Miaomiao Li Jian Liu Chunyu Wang Ding Xu
author_facet	Xiaoxiao Zhang Xinyue Liu Guowei Su Miaomiao Li Jian Liu Chunyu Wang Ding Xu
author_sort	Xiaoxiao Zhang
title	pH-dependent and dynamic interactions of cystatin C with heparan sulfate
title_short	pH-dependent and dynamic interactions of cystatin C with heparan sulfate
title_full	pH-dependent and dynamic interactions of cystatin C with heparan sulfate
title_fullStr	pH-dependent and dynamic interactions of cystatin C with heparan sulfate
title_full_unstemmed	pH-dependent and dynamic interactions of cystatin C with heparan sulfate
title_sort	ph-dependent and dynamic interactions of cystatin c with heparan sulfate
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/338128b64475457ebc8664996dc93af2
work_keys_str_mv	AT xiaoxiaozhang phdependentanddynamicinteractionsofcystatincwithheparansulfate AT xinyueliu phdependentanddynamicinteractionsofcystatincwithheparansulfate AT guoweisu phdependentanddynamicinteractionsofcystatincwithheparansulfate AT miaomiaoli phdependentanddynamicinteractionsofcystatincwithheparansulfate AT jianliu phdependentanddynamicinteractionsofcystatincwithheparansulfate AT chunyuwang phdependentanddynamicinteractionsofcystatincwithheparansulfate AT dingxu phdependentanddynamicinteractionsofcystatincwithheparansulfate
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pH-dependent and dynamic interactions of cystatin C with heparan sulfate

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