pH-dependent and dynamic interactions of cystatin C with heparan sulfate

Zhang et al. identify Cystatin C as a new heparan sulfate (HS) binding protein, however only at acidic pH (≤6.5). They further identify two isolated HS binding motifs on Cystatin C that are required to come together to form a complete HS-binding site, which is a unique property among known HS bindin...

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Bibliographic Details
Main Authors: Xiaoxiao Zhang, Xinyue Liu, Guowei Su, Miaomiao Li, Jian Liu, Chunyu Wang, Ding Xu
Format: article
Language:EN
Published: Nature Portfolio 2021
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Online Access:https://doaj.org/article/338128b64475457ebc8664996dc93af2
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