Regional brain functions in the resting state indicative of potential differences between depression and chronic pain

Abstract Complex relationships between depression and chronic pain have been reported in previous studies. However, only a few neuroimaging studies have investigated similarities and differences in neural systems underlying them. We examined the brain functions in the resting state of 43 patients wi...

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Autores principales:	Atsuo Yoshino, Yasumasa Okamoto, Mitsuru Doi, Naofumi Otsuru, Go Okada, Masahiro Takamura, Naho Ichikawa, Satoshi Yokoyama, Hidehisa Yamashita, Shigeto Yamawaki
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3382ae8d3ae7440c9ae21852e8959173
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spelling	oai:doaj.org-article:3382ae8d3ae7440c9ae21852e89591732021-12-02T11:40:58ZRegional brain functions in the resting state indicative of potential differences between depression and chronic pain10.1038/s41598-017-03522-12045-2322https://doaj.org/article/3382ae8d3ae7440c9ae21852e89591732017-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-03522-1https://doaj.org/toc/2045-2322Abstract Complex relationships between depression and chronic pain have been reported in previous studies. However, only a few neuroimaging studies have investigated similarities and differences in neural systems underlying them. We examined the brain functions in the resting state of 43 patients with depression, 41 patients with chronic pain (somatoform pain disorder) and 41 healthy controls, by using regional homogeneity (ReHo) and functional connectivity analysis. Depressive symptoms were assessed by using the Beck Depression Inventory-Second Edition (BDI-II). ReHo values for the dorsolateral prefrontal cortex (DLPFC) significantly decreased for chronic pain patients, and functional connectivity between the DLPFC and thalamus decreased only for these patients. These findings are indicative of distinct brain functions related to depression and chronic pain. Understanding these differences would further elucidate the pathophysiology of these conditions.Atsuo YoshinoYasumasa OkamotoMitsuru DoiNaofumi OtsuruGo OkadaMasahiro TakamuraNaho IchikawaSatoshi YokoyamaHidehisa YamashitaShigeto YamawakiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Atsuo Yoshino Yasumasa Okamoto Mitsuru Doi Naofumi Otsuru Go Okada Masahiro Takamura Naho Ichikawa Satoshi Yokoyama Hidehisa Yamashita Shigeto Yamawaki Regional brain functions in the resting state indicative of potential differences between depression and chronic pain
description	Abstract Complex relationships between depression and chronic pain have been reported in previous studies. However, only a few neuroimaging studies have investigated similarities and differences in neural systems underlying them. We examined the brain functions in the resting state of 43 patients with depression, 41 patients with chronic pain (somatoform pain disorder) and 41 healthy controls, by using regional homogeneity (ReHo) and functional connectivity analysis. Depressive symptoms were assessed by using the Beck Depression Inventory-Second Edition (BDI-II). ReHo values for the dorsolateral prefrontal cortex (DLPFC) significantly decreased for chronic pain patients, and functional connectivity between the DLPFC and thalamus decreased only for these patients. These findings are indicative of distinct brain functions related to depression and chronic pain. Understanding these differences would further elucidate the pathophysiology of these conditions.
format	article
author	Atsuo Yoshino Yasumasa Okamoto Mitsuru Doi Naofumi Otsuru Go Okada Masahiro Takamura Naho Ichikawa Satoshi Yokoyama Hidehisa Yamashita Shigeto Yamawaki
author_facet	Atsuo Yoshino Yasumasa Okamoto Mitsuru Doi Naofumi Otsuru Go Okada Masahiro Takamura Naho Ichikawa Satoshi Yokoyama Hidehisa Yamashita Shigeto Yamawaki
author_sort	Atsuo Yoshino
title	Regional brain functions in the resting state indicative of potential differences between depression and chronic pain
title_short	Regional brain functions in the resting state indicative of potential differences between depression and chronic pain
title_full	Regional brain functions in the resting state indicative of potential differences between depression and chronic pain
title_fullStr	Regional brain functions in the resting state indicative of potential differences between depression and chronic pain
title_full_unstemmed	Regional brain functions in the resting state indicative of potential differences between depression and chronic pain
title_sort	regional brain functions in the resting state indicative of potential differences between depression and chronic pain
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/3382ae8d3ae7440c9ae21852e8959173
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Regional brain functions in the resting state indicative of potential differences between depression and chronic pain

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