Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation

Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation

Identifying how genetic alterations cooperate in cancer is challenging. Here the authors analyze leukemia mouse models with both oncogenic NRAS and EZH2 mutations using single-cell RNA-sequencing, evaluate oncogenic cooperation, and identify GEM as a regulator of leukemia-initiating cells.

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Autores principales: Yuxuan Liu, Zhimin Gu, Hui Cao, Pranita Kaphle, Junhua Lyu, Yuannyu Zhang, Wenhuo Hu, Stephen S. Chung, Kathryn E. Dickerson, Jian Xu
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/3385b21a3e494a6886e8a09fb9eeb5ec
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spelling oai:doaj.org-article:3385b21a3e494a6886e8a09fb9eeb5ec2021-11-08T11:05:55ZConvergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation10.1038/s41467-021-26582-42041-1723https://doaj.org/article/3385b21a3e494a6886e8a09fb9eeb5ec2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26582-4https://doaj.org/toc/2041-1723Identifying how genetic alterations cooperate in cancer is challenging. Here the authors analyze leukemia mouse models with both oncogenic NRAS and EZH2 mutations using single-cell RNA-sequencing, evaluate oncogenic cooperation, and identify GEM as a regulator of leukemia-initiating cells.Yuxuan LiuZhimin GuHui CaoPranita KaphleJunhua LyuYuannyu ZhangWenhuo HuStephen S. ChungKathryn E. DickersonJian XuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuxuan Liu
Zhimin Gu
Hui Cao
Pranita Kaphle
Junhua Lyu
Yuannyu Zhang
Wenhuo Hu
Stephen S. Chung
Kathryn E. Dickerson
Jian Xu
Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation
description Identifying how genetic alterations cooperate in cancer is challenging. Here the authors analyze leukemia mouse models with both oncogenic NRAS and EZH2 mutations using single-cell RNA-sequencing, evaluate oncogenic cooperation, and identify GEM as a regulator of leukemia-initiating cells.
format article
author Yuxuan Liu
Zhimin Gu
Hui Cao
Pranita Kaphle
Junhua Lyu
Yuannyu Zhang
Wenhuo Hu
Stephen S. Chung
Kathryn E. Dickerson
Jian Xu
author_facet Yuxuan Liu
Zhimin Gu
Hui Cao
Pranita Kaphle
Junhua Lyu
Yuannyu Zhang
Wenhuo Hu
Stephen S. Chung
Kathryn E. Dickerson
Jian Xu
author_sort Yuxuan Liu
title Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation
title_short Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation
title_full Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation
title_fullStr Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation
title_full_unstemmed Convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation
title_sort convergence of oncogenic cooperation at single-cell and single-gene levels drives leukemic transformation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/3385b21a3e494a6886e8a09fb9eeb5ec
work_keys_str_mv AT yuxuanliu convergenceofoncogeniccooperationatsinglecellandsinglegenelevelsdrivesleukemictransformation
AT zhimingu convergenceofoncogeniccooperationatsinglecellandsinglegenelevelsdrivesleukemictransformation
AT huicao convergenceofoncogeniccooperationatsinglecellandsinglegenelevelsdrivesleukemictransformation
AT pranitakaphle convergenceofoncogeniccooperationatsinglecellandsinglegenelevelsdrivesleukemictransformation
AT junhualyu convergenceofoncogeniccooperationatsinglecellandsinglegenelevelsdrivesleukemictransformation
AT yuannyuzhang convergenceofoncogeniccooperationatsinglecellandsinglegenelevelsdrivesleukemictransformation
AT wenhuohu convergenceofoncogeniccooperationatsinglecellandsinglegenelevelsdrivesleukemictransformation
AT stephenschung convergenceofoncogeniccooperationatsinglecellandsinglegenelevelsdrivesleukemictransformation
AT kathrynedickerson convergenceofoncogeniccooperationatsinglecellandsinglegenelevelsdrivesleukemictransformation
AT jianxu convergenceofoncogeniccooperationatsinglecellandsinglegenelevelsdrivesleukemictransformation
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