Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.

<h4>Background</h4>Periodontal disease (PD) is one of the most common chronic inflammatory diseases. Esophageal cancer (EC) is also a common cause of death due to cancer among males. Systemic inflammatory processes have been shown to increase the risk of cancer. We conducted a retrospect...

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Autores principales:	Ya-Ling Lee, Hsiao-Yun Hu, Nan-Ping Yang, Pesus Chou, Dachen Chu
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3387c8037b394fa9acf33b4945d07ea9
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spelling	oai:doaj.org-article:3387c8037b394fa9acf33b4945d07ea92021-11-25T05:57:58ZDental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.1932-620310.1371/journal.pone.0109444https://doaj.org/article/3387c8037b394fa9acf33b4945d07ea92014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0109444https://doaj.org/toc/1932-6203<h4>Background</h4>Periodontal disease (PD) is one of the most common chronic inflammatory diseases. Esophageal cancer (EC) is also a common cause of death due to cancer among males. Systemic inflammatory processes have been shown to increase the risk of cancer. We conducted a retrospective cohort study to investigate the association between PD and EC.<h4>Methods</h4>A total of 718,409 subjects were recruited from the Taiwan National Health Insurance Research Database (NHIRD) and followed from January 1, 2000 to December 31, 2010. Of these, 519,831 subjects were diagnosed with PD and were grouped according to the most advanced treatment they received: dental prophylaxis, intensive treatment, or no treatment. The IRs of EC were compared among groups.<h4>Results</h4>A total of 682 patients developed EC, resulting in an overall IR of 0.11 case-number per 1000 person-years (‰/y). The dental prophylaxis group had a significantly lower IR of EC (0.06‰/y) than other groups (p<0.001). Multivariable Cox regression analysis further revealed that male subjects [hazard ratio (HR) = 10.04, 95% confidence interval (CI) = 7.58-13.30], as well as a history of esophageal ulcers (HR = 7.10, 95% CI = 5.03-10.01), alcohol abuse (HR = 5.46, 95% CI = 2.26-13.18), or esophageal reflux (HR = 1.86, 95% CI = 1.02-3.52), were factors associated with a higher risk of EC. And the dental prophylaxis group showed a significantly lower risk for EC (HR = 0.53, 95% CI = 0.44-0.65). Further subgroup analysis showed that the dental prophylaxis group among males had a significant lower risk (HR = 0.54, 95% CI = 0.44-0.66) for EC, while that of the females did not has statistically significant difference.<h4>Conclusion</h4>For this cohort, subjects received dental prophylaxis reduced the risk of EC compared to all PD and no PD groups among males.Ya-Ling LeeHsiao-Yun HuNan-Ping YangPesus ChouDachen ChuPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e109444 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Ya-Ling Lee Hsiao-Yun Hu Nan-Ping Yang Pesus Chou Dachen Chu Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.
description	<h4>Background</h4>Periodontal disease (PD) is one of the most common chronic inflammatory diseases. Esophageal cancer (EC) is also a common cause of death due to cancer among males. Systemic inflammatory processes have been shown to increase the risk of cancer. We conducted a retrospective cohort study to investigate the association between PD and EC.<h4>Methods</h4>A total of 718,409 subjects were recruited from the Taiwan National Health Insurance Research Database (NHIRD) and followed from January 1, 2000 to December 31, 2010. Of these, 519,831 subjects were diagnosed with PD and were grouped according to the most advanced treatment they received: dental prophylaxis, intensive treatment, or no treatment. The IRs of EC were compared among groups.<h4>Results</h4>A total of 682 patients developed EC, resulting in an overall IR of 0.11 case-number per 1000 person-years (‰/y). The dental prophylaxis group had a significantly lower IR of EC (0.06‰/y) than other groups (p<0.001). Multivariable Cox regression analysis further revealed that male subjects [hazard ratio (HR) = 10.04, 95% confidence interval (CI) = 7.58-13.30], as well as a history of esophageal ulcers (HR = 7.10, 95% CI = 5.03-10.01), alcohol abuse (HR = 5.46, 95% CI = 2.26-13.18), or esophageal reflux (HR = 1.86, 95% CI = 1.02-3.52), were factors associated with a higher risk of EC. And the dental prophylaxis group showed a significantly lower risk for EC (HR = 0.53, 95% CI = 0.44-0.65). Further subgroup analysis showed that the dental prophylaxis group among males had a significant lower risk (HR = 0.54, 95% CI = 0.44-0.66) for EC, while that of the females did not has statistically significant difference.<h4>Conclusion</h4>For this cohort, subjects received dental prophylaxis reduced the risk of EC compared to all PD and no PD groups among males.
format	article
author	Ya-Ling Lee Hsiao-Yun Hu Nan-Ping Yang Pesus Chou Dachen Chu
author_facet	Ya-Ling Lee Hsiao-Yun Hu Nan-Ping Yang Pesus Chou Dachen Chu
author_sort	Ya-Ling Lee
title	Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.
title_short	Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.
title_full	Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.
title_fullStr	Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.
title_full_unstemmed	Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.
title_sort	dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in taiwan.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/3387c8037b394fa9acf33b4945d07ea9
work_keys_str_mv	AT yalinglee dentalprophylaxisdecreasestheriskofesophagealcancerinmalesanationwidepopulationbasedstudyintaiwan AT hsiaoyunhu dentalprophylaxisdecreasestheriskofesophagealcancerinmalesanationwidepopulationbasedstudyintaiwan AT nanpingyang dentalprophylaxisdecreasestheriskofesophagealcancerinmalesanationwidepopulationbasedstudyintaiwan AT pesuschou dentalprophylaxisdecreasestheriskofesophagealcancerinmalesanationwidepopulationbasedstudyintaiwan AT dachenchu dentalprophylaxisdecreasestheriskofesophagealcancerinmalesanationwidepopulationbasedstudyintaiwan
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Dental prophylaxis decreases the risk of esophageal cancer in males; a nationwide population-based study in Taiwan.

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