Analysis of the shape of the T-wave in congenital long-QT syndrome type 3 by geometric morphometrics

Abstract The characteristic shape of the T-wave in congenital long-QT syndrome type 3 (LQTS3) is considered a late-onset T-wave. We analyzed the difference in the shapes of the T-waves of V5 in the electrocardiograms (ECGs) of LQTS3 cases and normal subjects using generalized Procrustes analysis. Th...

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Autores principales:	Hitoshi Horigome, Yasuhiro Ishikawa, Kazuhiro Takahashi, Masao Yoshinaga, Naokata Sumitomo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/338b9e9cbb3147fc91aaea4420c9bb6a
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spelling	oai:doaj.org-article:338b9e9cbb3147fc91aaea4420c9bb6a2021-12-02T17:48:00ZAnalysis of the shape of the T-wave in congenital long-QT syndrome type 3 by geometric morphometrics10.1038/s41598-021-91346-52045-2322https://doaj.org/article/338b9e9cbb3147fc91aaea4420c9bb6a2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91346-5https://doaj.org/toc/2045-2322Abstract The characteristic shape of the T-wave in congenital long-QT syndrome type 3 (LQTS3) is considered a late-onset T-wave. We analyzed the difference in the shapes of the T-waves of V5 in the electrocardiograms (ECGs) of LQTS3 cases and normal subjects using generalized Procrustes analysis. The J and Q points of LQTS3 cases are shifted to the upper left compared to those of normal subjects. SdFmax is the point on the ECG where the second derivative is first maximized. SdFmax is the point where the change in the slope of the ascending limb of the T-wave is maximized. SdFmax in LQTS3 cases is shifted to the lower right compared to normal subjects. The interval from J to SdFmax in LQTS3 cases is expanded compared with that of normal subjects. From principal component analysis of the Procrustes mean shape of the T-wave landmarks, the second principal component shows a shift of SdFmax to the lower right. These results can quantitatively explain why the T-wave of LQTS3 cases looks like a late-onset T-wave. After being fitted to a multivariate logistic regression model, LQTS3 cases and normal subjects can be distinguished by the second independent component.Hitoshi HorigomeYasuhiro IshikawaKazuhiro TakahashiMasao YoshinagaNaokata SumitomoNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Hitoshi Horigome Yasuhiro Ishikawa Kazuhiro Takahashi Masao Yoshinaga Naokata Sumitomo Analysis of the shape of the T-wave in congenital long-QT syndrome type 3 by geometric morphometrics
description	Abstract The characteristic shape of the T-wave in congenital long-QT syndrome type 3 (LQTS3) is considered a late-onset T-wave. We analyzed the difference in the shapes of the T-waves of V5 in the electrocardiograms (ECGs) of LQTS3 cases and normal subjects using generalized Procrustes analysis. The J and Q points of LQTS3 cases are shifted to the upper left compared to those of normal subjects. SdFmax is the point on the ECG where the second derivative is first maximized. SdFmax is the point where the change in the slope of the ascending limb of the T-wave is maximized. SdFmax in LQTS3 cases is shifted to the lower right compared to normal subjects. The interval from J to SdFmax in LQTS3 cases is expanded compared with that of normal subjects. From principal component analysis of the Procrustes mean shape of the T-wave landmarks, the second principal component shows a shift of SdFmax to the lower right. These results can quantitatively explain why the T-wave of LQTS3 cases looks like a late-onset T-wave. After being fitted to a multivariate logistic regression model, LQTS3 cases and normal subjects can be distinguished by the second independent component.
format	article
author	Hitoshi Horigome Yasuhiro Ishikawa Kazuhiro Takahashi Masao Yoshinaga Naokata Sumitomo
author_facet	Hitoshi Horigome Yasuhiro Ishikawa Kazuhiro Takahashi Masao Yoshinaga Naokata Sumitomo
author_sort	Hitoshi Horigome
title	Analysis of the shape of the T-wave in congenital long-QT syndrome type 3 by geometric morphometrics
title_short	Analysis of the shape of the T-wave in congenital long-QT syndrome type 3 by geometric morphometrics
title_full	Analysis of the shape of the T-wave in congenital long-QT syndrome type 3 by geometric morphometrics
title_fullStr	Analysis of the shape of the T-wave in congenital long-QT syndrome type 3 by geometric morphometrics
title_full_unstemmed	Analysis of the shape of the T-wave in congenital long-QT syndrome type 3 by geometric morphometrics
title_sort	analysis of the shape of the t-wave in congenital long-qt syndrome type 3 by geometric morphometrics
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/338b9e9cbb3147fc91aaea4420c9bb6a
work_keys_str_mv	AT hitoshihorigome analysisoftheshapeofthetwaveincongenitallongqtsyndrometype3bygeometricmorphometrics AT yasuhiroishikawa analysisoftheshapeofthetwaveincongenitallongqtsyndrometype3bygeometricmorphometrics AT kazuhirotakahashi analysisoftheshapeofthetwaveincongenitallongqtsyndrometype3bygeometricmorphometrics AT masaoyoshinaga analysisoftheshapeofthetwaveincongenitallongqtsyndrometype3bygeometricmorphometrics AT naokatasumitomo analysisoftheshapeofthetwaveincongenitallongqtsyndrometype3bygeometricmorphometrics
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Analysis of the shape of the T-wave in congenital long-QT syndrome type 3 by geometric morphometrics

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