Endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease

Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of chronic rhinosinusitis with nasal polyposis, adult-onset asthma and non-IgE mediated reactions to aspirin and other cyclooxygenase-1 (COX-1) inhibitors. Patients with AERD are dependent on COX-1 activity to maintain prod...

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Autor principal:	Joshua M. Levy
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2020
Materias:	Chronic rhinosinusitis Aspirin-exacerbated respiratory disease Endogenous cannabinoid Endocannabinoids Eicosanoids Prostaglandins Otorhinolaryngology RF1-547 Surgery RD1-811
Acceso en línea:	https://doaj.org/article/339297f3f15043c4ab6019e7b26d2267
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spelling	oai:doaj.org-article:339297f3f15043c4ab6019e7b26d22672021-12-02T14:17:38ZEndogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease2095-881110.1016/j.wjorl.2020.07.004https://doaj.org/article/339297f3f15043c4ab6019e7b26d22672020-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095881120301049https://doaj.org/toc/2095-8811Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of chronic rhinosinusitis with nasal polyposis, adult-onset asthma and non-IgE mediated reactions to aspirin and other cyclooxygenase-1 (COX-1) inhibitors. Patients with AERD are dependent on COX-1 activity to maintain production of prostaglandin (PG) species, such as PGE2, which maintain physiologic levels of inflammation and limit the production of pro-inflammatory cysteinyl leukotrienes. The endogenous cannabinoid system is a family of immunomodulatory lipids and their innate g-protein coupled receptors that are closely related to arachidonic acid and may modulate inflammation via several pathways, including the direct production of metabolically active prostaglandin glycerol-esters. A recent pilot study has identified the significant up-regulation of the peripherally expressed, type-2 cannabinoid receptor (CB2) in AERD nasal polyps versus control tissues from patients with either allergic fungal rhinosinusitis or no history of chronic sinonasal inflammation. These early findings suggest the involvement of increased endogenous cannabinoid activity in prostaglandin deficient states such as AERD. Future study is needed to explore the significance of these findings, with specific investigation of the impact of CB2 activation on markers of airway inflammation, as well as the potential to measure CB2 expression as a screening biomarker for the evaluation of unrecognized disease.Joshua M. LevyKeAi Communications Co., Ltd.articleChronic rhinosinusitisAspirin-exacerbated respiratory diseaseEndogenous cannabinoidEndocannabinoidsEicosanoidsProstaglandinsOtorhinolaryngologyRF1-547SurgeryRD1-811ENWorld Journal of Otorhinolaryngology-Head and Neck Surgery, Vol 6, Iss 4, Pp 255-257 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Chronic rhinosinusitis Aspirin-exacerbated respiratory disease Endogenous cannabinoid Endocannabinoids Eicosanoids Prostaglandins Otorhinolaryngology RF1-547 Surgery RD1-811
spellingShingle	Chronic rhinosinusitis Aspirin-exacerbated respiratory disease Endogenous cannabinoid Endocannabinoids Eicosanoids Prostaglandins Otorhinolaryngology RF1-547 Surgery RD1-811 Joshua M. Levy Endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease
description	Aspirin-exacerbated respiratory disease (AERD) is characterized by the triad of chronic rhinosinusitis with nasal polyposis, adult-onset asthma and non-IgE mediated reactions to aspirin and other cyclooxygenase-1 (COX-1) inhibitors. Patients with AERD are dependent on COX-1 activity to maintain production of prostaglandin (PG) species, such as PGE2, which maintain physiologic levels of inflammation and limit the production of pro-inflammatory cysteinyl leukotrienes. The endogenous cannabinoid system is a family of immunomodulatory lipids and their innate g-protein coupled receptors that are closely related to arachidonic acid and may modulate inflammation via several pathways, including the direct production of metabolically active prostaglandin glycerol-esters. A recent pilot study has identified the significant up-regulation of the peripherally expressed, type-2 cannabinoid receptor (CB2) in AERD nasal polyps versus control tissues from patients with either allergic fungal rhinosinusitis or no history of chronic sinonasal inflammation. These early findings suggest the involvement of increased endogenous cannabinoid activity in prostaglandin deficient states such as AERD. Future study is needed to explore the significance of these findings, with specific investigation of the impact of CB2 activation on markers of airway inflammation, as well as the potential to measure CB2 expression as a screening biomarker for the evaluation of unrecognized disease.
format	article
author	Joshua M. Levy
author_facet	Joshua M. Levy
author_sort	Joshua M. Levy
title	Endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease
title_short	Endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease
title_full	Endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease
title_fullStr	Endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease
title_full_unstemmed	Endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease
title_sort	endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease
publisher	KeAi Communications Co., Ltd.
publishDate	2020
url	https://doaj.org/article/339297f3f15043c4ab6019e7b26d2267
work_keys_str_mv	AT joshuamlevy endogenouscannabinoidsmayregulatechronicinflammationinaspirinexacerbatedrespiratorydisease
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Endogenous cannabinoids may regulate chronic inflammation in aspirin-exacerbated respiratory disease

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