<i>Leclercia adecarboxylata</i> as Emerging Pathogen in Human Infections: Clinical Features and Antimicrobial Susceptibility Testing
(1) Background: <i>Leclercia adecarboxylata</i> (<i>L. adecarboxylata</i>) is a gram-negative bacillus of the Enterobacteriaceae family, which is uncommonly isolated from clinical specimens. <i>L. adecarboxylata</i> is considered as an aquatic opportunistic pathog...
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| Autores principales: | , , , , , , , , , |
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| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
MDPI AG
2021
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| Materias: | |
| Acceso en línea: | https://doaj.org/article/3394b0225f484f1aa63c23c2c060ad71 |
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| Sumario: | (1) Background: <i>Leclercia adecarboxylata</i> (<i>L. adecarboxylata</i>) is a gram-negative bacillus of the Enterobacteriaceae family, which is uncommonly isolated from clinical specimens. <i>L. adecarboxylata</i> is considered as an aquatic opportunistic pathogen and most of the human infections are polymicrobial and usually occur in immunocompromised hosts. (2) Methods: In this retrospective study, we included all <i>L. adecarboxylata</i> strains since the introduction of MALDI-TOF MS in the Microbiology Department of <i>Nord Franche-Comté</i> Hospital, France (from 1 March 2015 to 31 July 2019). We studied demographic characteristics, comorbidities, characteristics of the current infection and outcome as well as antimicrobial susceptibility testing in all isolates. (3) Results: A total of 8 samples were identified (in 6 patients (4M/2F), with a recurrent <i>L. adecarboxylata</i> infection in 2 patients). The patients’ mean age was 66.2 years (range: 19–84). All patients were considered as immunocompetent, except a peritoneal dialysis patient with kidney transplantation. An exposition to an aquatic environment was identified in one patient. The most prevalent clinical feature was catheter-associated male urinary tract infection (in 3 cases) followed by ventilator-associated pneumonia (in 2 cases). One of 6 patients presented <i>L. adecarboxylata</i> bacteremia. <i>L. adecarboxylata</i> was part of a polymicrobial infection in 4 patients. The isolates showed a high susceptibility to all tested antibiotics, except one strain, which was resistant to fosfomycin. All patients with <i>L. adecarboxylata</i> infection were treated with antibiotics with a favorable outcome. (4) Conclusion: This study confirms the pathogenicity of <i>L. adecarboxylata</i>, even in immunocompetent patients, with a high susceptibility to antibiotics. |
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