Involvement of the dopaminergic system in the reward-related behavior of pregabalin

Abstract There has been an increase in cases of drug addiction and prescription drug abuse worldwide. Recently, pregabalin abuse has been a focus for many healthcare agencies, as highlighted by epidemiological studies. We previously evaluated the possibility of pregabalin abuse using the conditioned...

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Autores principales:	Yusuf S. Althobaiti, Farooq M. Almutairi, Fahad S. Alshehri, Ebtehal Altowairqi, Aliyah M. Marghalani, Amal A. Alghorabi, Walaa F. Alsanie, Ahmed Gaber, Hashem O. Alsaab, Atiah H. Almalki, Alqassem Y. Hakami, Turki Alkhalifa, Ahmad D. Almalki, Ana M. G. Hardy, Zahoor A. Shah
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/3398dfba11a247c8abe43f67d64910f4
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spelling	oai:doaj.org-article:3398dfba11a247c8abe43f67d64910f42021-12-02T14:58:45ZInvolvement of the dopaminergic system in the reward-related behavior of pregabalin10.1038/s41598-021-88429-82045-2322https://doaj.org/article/3398dfba11a247c8abe43f67d64910f42021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-88429-8https://doaj.org/toc/2045-2322Abstract There has been an increase in cases of drug addiction and prescription drug abuse worldwide. Recently, pregabalin abuse has been a focus for many healthcare agencies, as highlighted by epidemiological studies. We previously evaluated the possibility of pregabalin abuse using the conditioned place preference (CPP) paradigm. We observed that a 60 mg/kg dose could induce CPP in mice and that pregabalin-rewarding properties were mediated through glutamate neurotransmission. Notably, the dopaminergic reward circuitry is also known to play a crucial role in medication-seeking behavior. Therefore, this study aimed to explore the possible involvement of dopaminergic receptor-1 in pregabalin-induced CPP. Mice were randomly allocated to receive saline or the dopamine-1 receptor antagonist SKF-83566 (0.03 mg/kg, intraperitoneal). After 30 min, the mice received either saline or pregabalin (60 mg/kg) during the conditioning phase. Among the control groups that received saline or SKF-83566, the time spent in the two conditioning chambers was not significantly altered. However, among the pregabalin-treated group, there was a marked increase in the time spent in the drug-paired chamber compared to the time spent in the vehicle-paired chamber. Notably, blocking dopamine-1 receptors with SKF-83566 completely prevented pregabalin-induced place preference, thus demonstrating the engagement of the dopaminergic system in pregabalin-induced reward-related behavior.Yusuf S. AlthobaitiFarooq M. AlmutairiFahad S. AlshehriEbtehal AltowairqiAliyah M. MarghalaniAmal A. AlghorabiWalaa F. AlsanieAhmed GaberHashem O. AlsaabAtiah H. AlmalkiAlqassem Y. HakamiTurki AlkhalifaAhmad D. AlmalkiAna M. G. HardyZahoor A. ShahNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yusuf S. Althobaiti Farooq M. Almutairi Fahad S. Alshehri Ebtehal Altowairqi Aliyah M. Marghalani Amal A. Alghorabi Walaa F. Alsanie Ahmed Gaber Hashem O. Alsaab Atiah H. Almalki Alqassem Y. Hakami Turki Alkhalifa Ahmad D. Almalki Ana M. G. Hardy Zahoor A. Shah Involvement of the dopaminergic system in the reward-related behavior of pregabalin
description	Abstract There has been an increase in cases of drug addiction and prescription drug abuse worldwide. Recently, pregabalin abuse has been a focus for many healthcare agencies, as highlighted by epidemiological studies. We previously evaluated the possibility of pregabalin abuse using the conditioned place preference (CPP) paradigm. We observed that a 60 mg/kg dose could induce CPP in mice and that pregabalin-rewarding properties were mediated through glutamate neurotransmission. Notably, the dopaminergic reward circuitry is also known to play a crucial role in medication-seeking behavior. Therefore, this study aimed to explore the possible involvement of dopaminergic receptor-1 in pregabalin-induced CPP. Mice were randomly allocated to receive saline or the dopamine-1 receptor antagonist SKF-83566 (0.03 mg/kg, intraperitoneal). After 30 min, the mice received either saline or pregabalin (60 mg/kg) during the conditioning phase. Among the control groups that received saline or SKF-83566, the time spent in the two conditioning chambers was not significantly altered. However, among the pregabalin-treated group, there was a marked increase in the time spent in the drug-paired chamber compared to the time spent in the vehicle-paired chamber. Notably, blocking dopamine-1 receptors with SKF-83566 completely prevented pregabalin-induced place preference, thus demonstrating the engagement of the dopaminergic system in pregabalin-induced reward-related behavior.
format	article
author	Yusuf S. Althobaiti Farooq M. Almutairi Fahad S. Alshehri Ebtehal Altowairqi Aliyah M. Marghalani Amal A. Alghorabi Walaa F. Alsanie Ahmed Gaber Hashem O. Alsaab Atiah H. Almalki Alqassem Y. Hakami Turki Alkhalifa Ahmad D. Almalki Ana M. G. Hardy Zahoor A. Shah
author_facet	Yusuf S. Althobaiti Farooq M. Almutairi Fahad S. Alshehri Ebtehal Altowairqi Aliyah M. Marghalani Amal A. Alghorabi Walaa F. Alsanie Ahmed Gaber Hashem O. Alsaab Atiah H. Almalki Alqassem Y. Hakami Turki Alkhalifa Ahmad D. Almalki Ana M. G. Hardy Zahoor A. Shah
author_sort	Yusuf S. Althobaiti
title	Involvement of the dopaminergic system in the reward-related behavior of pregabalin
title_short	Involvement of the dopaminergic system in the reward-related behavior of pregabalin
title_full	Involvement of the dopaminergic system in the reward-related behavior of pregabalin
title_fullStr	Involvement of the dopaminergic system in the reward-related behavior of pregabalin
title_full_unstemmed	Involvement of the dopaminergic system in the reward-related behavior of pregabalin
title_sort	involvement of the dopaminergic system in the reward-related behavior of pregabalin
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/3398dfba11a247c8abe43f67d64910f4
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Involvement of the dopaminergic system in the reward-related behavior of pregabalin

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