Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions

Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and GITR ligand (GITRL) regulate immune cell activities, including anti-tumor immune responses. Structures and visualization of human and mouse GITR–GITRL complexes offer insight into the architecture of higher-order membra...

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Main Authors:	Feng Wang, Bryant Chau, Sean M. West, Christopher R. Kimberlin, Fei Cao, Flavio Schwarz, Barbara Aguilar, Minhua Han, Winse Morishige, Christine Bee, Gavin Dollinger, Arvind Rajpal, Pavel Strop
Format:	article
Language:	EN
Published:	Nature Portfolio 2021
Subjects:	Science Q
Online Access:	https://doaj.org/article/339a2bcd2cae4b929cc7ae8a3d566f01
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spelling	oai:doaj.org-article:339a2bcd2cae4b929cc7ae8a3d566f012021-12-02T15:52:37ZStructures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions10.1038/s41467-021-21563-z2041-1723https://doaj.org/article/339a2bcd2cae4b929cc7ae8a3d566f012021-03-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-21563-zhttps://doaj.org/toc/2041-1723Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and GITR ligand (GITRL) regulate immune cell activities, including anti-tumor immune responses. Structures and visualization of human and mouse GITR–GITRL complexes offer insight into the architecture of higher-order membrane assemblies, and their signaling.Feng WangBryant ChauSean M. WestChristopher R. KimberlinFei CaoFlavio SchwarzBarbara AguilarMinhua HanWinse MorishigeChristine BeeGavin DollingerArvind RajpalPavel StropNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Feng Wang Bryant Chau Sean M. West Christopher R. Kimberlin Fei Cao Flavio Schwarz Barbara Aguilar Minhua Han Winse Morishige Christine Bee Gavin Dollinger Arvind Rajpal Pavel Strop Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions
description	Glucocorticoid-induced tumor necrosis factor receptor-related protein (GITR) and GITR ligand (GITRL) regulate immune cell activities, including anti-tumor immune responses. Structures and visualization of human and mouse GITR–GITRL complexes offer insight into the architecture of higher-order membrane assemblies, and their signaling.
format	article
author	Feng Wang Bryant Chau Sean M. West Christopher R. Kimberlin Fei Cao Flavio Schwarz Barbara Aguilar Minhua Han Winse Morishige Christine Bee Gavin Dollinger Arvind Rajpal Pavel Strop
author_facet	Feng Wang Bryant Chau Sean M. West Christopher R. Kimberlin Fei Cao Flavio Schwarz Barbara Aguilar Minhua Han Winse Morishige Christine Bee Gavin Dollinger Arvind Rajpal Pavel Strop
author_sort	Feng Wang
title	Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions
title_short	Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions
title_full	Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions
title_fullStr	Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions
title_full_unstemmed	Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions
title_sort	structures of mouse and human gitr–gitrl complexes reveal unique tnf superfamily interactions
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/339a2bcd2cae4b929cc7ae8a3d566f01
work_keys_str_mv	AT fengwang structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT bryantchau structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT seanmwest structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT christopherrkimberlin structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT feicao structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT flavioschwarz structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT barbaraaguilar structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT minhuahan structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT winsemorishige structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT christinebee structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT gavindollinger structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT arvindrajpal structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions AT pavelstrop structuresofmouseandhumangitrgitrlcomplexesrevealuniquetnfsuperfamilyinteractions
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Structures of mouse and human GITR–GITRL complexes reveal unique TNF superfamily interactions

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