Cardiorespiratory responses to exercise related to post-stroke fatigue severity

Abstract Physical deconditioning after stroke may induce post-stroke fatigue. However, research on this association is limited. Our primary objective was to investigate the associations of post-stroke fatigue severity with oxygen uptake ( $$\dot{\mathrm{V}}$$ V ˙ O2) at peak exercise and the time co...

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Autores principales:	Kazuaki Oyake, Yasuto Baba, Yuki Suda, Jun Murayama, Ayumi Mochida, Yuki Ito, Honoka Abe, Kunitsugu Kondo, Yohei Otaka, Kimito Momose
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/339ca6e8ec9b40ea9838e92ca9a7a7d6
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spelling	oai:doaj.org-article:339ca6e8ec9b40ea9838e92ca9a7a7d62021-12-02T16:04:27ZCardiorespiratory responses to exercise related to post-stroke fatigue severity10.1038/s41598-021-92127-w2045-2322https://doaj.org/article/339ca6e8ec9b40ea9838e92ca9a7a7d62021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-92127-whttps://doaj.org/toc/2045-2322Abstract Physical deconditioning after stroke may induce post-stroke fatigue. However, research on this association is limited. Our primary objective was to investigate the associations of post-stroke fatigue severity with oxygen uptake ( $$\dot{\mathrm{V}}$$ V ˙ O2) at peak exercise and the time constant of $$\dot{\mathrm{V}}$$ V ˙ O2 kinetics (τ $$\dot{\mathrm{V}}$$ V ˙ O2) at exercise onset. The secondary objective was to examine the associations between fatigue and cardiorespiratory variables potentially affecting $$\dot{\mathrm{V}}$$ V ˙ O2 during exercise. Twenty-three inpatients from a subacute rehabilitation ward were enrolled in this study. The median (interquartile range) Fatigue Severity Scale (FSS) score, as a measure of fatigue, was 32 (range 27–42) points. The FSS score was not associated with $$\dot{\mathrm{V}}$$ V ˙ O2 at peak exercise during a symptom-limited graded exercise test (rho = − 0.264; p = 0.224), whereas it was significantly associated with τ $$\dot{\mathrm{V}}$$ V ˙ O2 during a submaximal constant-load exercise test (rho = 0.530; p = 0.009). A higher FSS score also significantly correlated with a longer time constant of cardiac output (CO) kinetics (rho = 0.476; p = 0.022). Our findings suggest that severe post-stroke fatigue is associated with delayed increases in $$\dot{\mathrm{V}}$$ V ˙ O2 and CO at the onset of exercise. Our findings can contribute to the development of an appropriate rehabilitation programme for individuals with post-stroke fatigue.Kazuaki OyakeYasuto BabaYuki SudaJun MurayamaAyumi MochidaYuki ItoHonoka AbeKunitsugu KondoYohei OtakaKimito MomoseNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Kazuaki Oyake Yasuto Baba Yuki Suda Jun Murayama Ayumi Mochida Yuki Ito Honoka Abe Kunitsugu Kondo Yohei Otaka Kimito Momose Cardiorespiratory responses to exercise related to post-stroke fatigue severity
description	Abstract Physical deconditioning after stroke may induce post-stroke fatigue. However, research on this association is limited. Our primary objective was to investigate the associations of post-stroke fatigue severity with oxygen uptake ( $$\dot{\mathrm{V}}$$ V ˙ O2) at peak exercise and the time constant of $$\dot{\mathrm{V}}$$ V ˙ O2 kinetics (τ $$\dot{\mathrm{V}}$$ V ˙ O2) at exercise onset. The secondary objective was to examine the associations between fatigue and cardiorespiratory variables potentially affecting $$\dot{\mathrm{V}}$$ V ˙ O2 during exercise. Twenty-three inpatients from a subacute rehabilitation ward were enrolled in this study. The median (interquartile range) Fatigue Severity Scale (FSS) score, as a measure of fatigue, was 32 (range 27–42) points. The FSS score was not associated with $$\dot{\mathrm{V}}$$ V ˙ O2 at peak exercise during a symptom-limited graded exercise test (rho = − 0.264; p = 0.224), whereas it was significantly associated with τ $$\dot{\mathrm{V}}$$ V ˙ O2 during a submaximal constant-load exercise test (rho = 0.530; p = 0.009). A higher FSS score also significantly correlated with a longer time constant of cardiac output (CO) kinetics (rho = 0.476; p = 0.022). Our findings suggest that severe post-stroke fatigue is associated with delayed increases in $$\dot{\mathrm{V}}$$ V ˙ O2 and CO at the onset of exercise. Our findings can contribute to the development of an appropriate rehabilitation programme for individuals with post-stroke fatigue.
format	article
author	Kazuaki Oyake Yasuto Baba Yuki Suda Jun Murayama Ayumi Mochida Yuki Ito Honoka Abe Kunitsugu Kondo Yohei Otaka Kimito Momose
author_facet	Kazuaki Oyake Yasuto Baba Yuki Suda Jun Murayama Ayumi Mochida Yuki Ito Honoka Abe Kunitsugu Kondo Yohei Otaka Kimito Momose
author_sort	Kazuaki Oyake
title	Cardiorespiratory responses to exercise related to post-stroke fatigue severity
title_short	Cardiorespiratory responses to exercise related to post-stroke fatigue severity
title_full	Cardiorespiratory responses to exercise related to post-stroke fatigue severity
title_fullStr	Cardiorespiratory responses to exercise related to post-stroke fatigue severity
title_full_unstemmed	Cardiorespiratory responses to exercise related to post-stroke fatigue severity
title_sort	cardiorespiratory responses to exercise related to post-stroke fatigue severity
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/339ca6e8ec9b40ea9838e92ca9a7a7d6
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Cardiorespiratory responses to exercise related to post-stroke fatigue severity

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