GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS

Objective: To establish the correlation between glycated hemoglobin (HbA1c) and lipid profile in patients with type 2 diabetes mellitus (T2DM). Study Design: Correlation study. Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi (PEMH), Medical Outpatient department (OPD), f...

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Autores principales:	Abdul Moueed Tariq, Abdul Latif Khattak, Hafiz Yasir Rehman, Faisal Mehmood, Raheel Akhtar, Ejaz Ali
Formato:	article
Lenguaje:	EN
Publicado:	Army Medical College Rawalpindi 2020
Materias:	dyslipidemia glycated hemoglobin type 2 dm Medicine R Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/339ccf1fff1a477a9b7997d95bae70a2
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spelling	oai:doaj.org-article:339ccf1fff1a477a9b7997d95bae70a22021-12-02T17:21:15ZGLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS0030-96482411-8842https://doaj.org/article/339ccf1fff1a477a9b7997d95bae70a22020-10-01T00:00:00Zhttps://pafmj.org/index.php/PAFMJ/article/view/5609https://doaj.org/toc/0030-9648https://doaj.org/toc/2411-8842Objective: To establish the correlation between glycated hemoglobin (HbA1c) and lipid profile in patients with type 2 diabetes mellitus (T2DM). Study Design: Correlation study. Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi (PEMH), Medical Outpatient department (OPD), from Nov 2017 to May 2018. Methodology: A total of 160 patients with type 2 diabetes mellitus of both genders, 30-70 years of age presenting in OPD were included in study, while those with T1DM, CKD stage 3 and above, infection or diabetic foot, any endocrine disease and female patients with pregnancy were excluded from the study. The blood samples were taken for blood sugar random (BSR), blood sugar fasting (BSF), haemoglobin A1c (HbA1c), lipid profile and results were collected next day. The Pearson correlation test was used to analyze correlations. Results: Among 160 patients the mean age was 57.28 ± 10.13 years, 81 (50.6%) were males while 79 (49.4%) were females. The 34 (21.20%) patients had good, while 125 (78.80%) had poor glycaemic control using haemoglobin A1c of 7% as a cut off. A positive and statistically significant correlation was observed between haemoglobin A1c and total cholesterol (r=0.233, p<0.01), triglycerides (r=0.172, p<0.05), and a correlation which was positive but statistically not significant was observed between haemoglobin A1c and LDL-C (r=0.105, p=0.260) while a statistically insignificant negative correlation was observed between haemoglobin A1c and HDL-C (r=-0.041, p=0.652). Conclusion: A significant positive correlation was found between haemoglobin A1c and total cholesterol and triglycerides. Haemoglobin A1c can also be used as a biomarker to predict dyslipidemias in patients with type 2 diabetes mellitus.Abdul Moueed TariqAbdul Latif KhattakHafiz Yasir RehmanFaisal MehmoodRaheel AkhtarEjaz AliArmy Medical College Rawalpindiarticledyslipidemiaglycated hemoglobintype 2 dmMedicineRMedicine (General)R5-920ENPakistan Armed Forces Medical Journal, Vol 70, Iss 5, Pp 1581-1585 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	dyslipidemia glycated hemoglobin type 2 dm Medicine R Medicine (General) R5-920
spellingShingle	dyslipidemia glycated hemoglobin type 2 dm Medicine R Medicine (General) R5-920 Abdul Moueed Tariq Abdul Latif Khattak Hafiz Yasir Rehman Faisal Mehmood Raheel Akhtar Ejaz Ali GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS
description	Objective: To establish the correlation between glycated hemoglobin (HbA1c) and lipid profile in patients with type 2 diabetes mellitus (T2DM). Study Design: Correlation study. Place and Duration of Study: Pak Emirates Military Hospital Rawalpindi (PEMH), Medical Outpatient department (OPD), from Nov 2017 to May 2018. Methodology: A total of 160 patients with type 2 diabetes mellitus of both genders, 30-70 years of age presenting in OPD were included in study, while those with T1DM, CKD stage 3 and above, infection or diabetic foot, any endocrine disease and female patients with pregnancy were excluded from the study. The blood samples were taken for blood sugar random (BSR), blood sugar fasting (BSF), haemoglobin A1c (HbA1c), lipid profile and results were collected next day. The Pearson correlation test was used to analyze correlations. Results: Among 160 patients the mean age was 57.28 ± 10.13 years, 81 (50.6%) were males while 79 (49.4%) were females. The 34 (21.20%) patients had good, while 125 (78.80%) had poor glycaemic control using haemoglobin A1c of 7% as a cut off. A positive and statistically significant correlation was observed between haemoglobin A1c and total cholesterol (r=0.233, p<0.01), triglycerides (r=0.172, p<0.05), and a correlation which was positive but statistically not significant was observed between haemoglobin A1c and LDL-C (r=0.105, p=0.260) while a statistically insignificant negative correlation was observed between haemoglobin A1c and HDL-C (r=-0.041, p=0.652). Conclusion: A significant positive correlation was found between haemoglobin A1c and total cholesterol and triglycerides. Haemoglobin A1c can also be used as a biomarker to predict dyslipidemias in patients with type 2 diabetes mellitus.
format	article
author	Abdul Moueed Tariq Abdul Latif Khattak Hafiz Yasir Rehman Faisal Mehmood Raheel Akhtar Ejaz Ali
author_facet	Abdul Moueed Tariq Abdul Latif Khattak Hafiz Yasir Rehman Faisal Mehmood Raheel Akhtar Ejaz Ali
author_sort	Abdul Moueed Tariq
title	GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS
title_short	GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS
title_full	GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS
title_fullStr	GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS
title_full_unstemmed	GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS
title_sort	glycated hemoglobin as a biomarker to predict dyslipidemia in type 2 diabetes mellitus
publisher	Army Medical College Rawalpindi
publishDate	2020
url	https://doaj.org/article/339ccf1fff1a477a9b7997d95bae70a2
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GLYCATED HEMOGLOBIN AS A BIOMARKER TO PREDICT DYSLIPIDEMIA IN TYPE 2 DIABETES MELLITUS

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