D-mannose suppresses macrophage IL-1β production

Mannose is present at trace levels in blood and regulates cancer growth. Here the authors show that supraphysiological levels of mannose can also regulate macrophages, limiting their production of IL-1β and increasing resistance of mice to LPS-induced endotoxemia and DSS-induced colitis.

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Autores principales:	Simone Torretta, Alessandra Scagliola, Luisa Ricci, Francesco Mainini, Sabrina Di Marco, Ivan Cuccovillo, Anna Kajaste-Rudnitski, David Sumpton, Kevin M. Ryan, Simone Cardaci
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33a11b42ec3643e18f2c5585a702657e
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spelling	oai:doaj.org-article:33a11b42ec3643e18f2c5585a702657e2021-12-02T13:57:45ZD-mannose suppresses macrophage IL-1β production10.1038/s41467-020-20164-62041-1723https://doaj.org/article/33a11b42ec3643e18f2c5585a702657e2020-12-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-20164-6https://doaj.org/toc/2041-1723Mannose is present at trace levels in blood and regulates cancer growth. Here the authors show that supraphysiological levels of mannose can also regulate macrophages, limiting their production of IL-1β and increasing resistance of mice to LPS-induced endotoxemia and DSS-induced colitis.Simone TorrettaAlessandra ScagliolaLuisa RicciFrancesco MaininiSabrina Di MarcoIvan CuccovilloAnna Kajaste-RudnitskiDavid SumptonKevin M. RyanSimone CardaciNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Simone Torretta Alessandra Scagliola Luisa Ricci Francesco Mainini Sabrina Di Marco Ivan Cuccovillo Anna Kajaste-Rudnitski David Sumpton Kevin M. Ryan Simone Cardaci D-mannose suppresses macrophage IL-1β production
description	Mannose is present at trace levels in blood and regulates cancer growth. Here the authors show that supraphysiological levels of mannose can also regulate macrophages, limiting their production of IL-1β and increasing resistance of mice to LPS-induced endotoxemia and DSS-induced colitis.
format	article
author	Simone Torretta Alessandra Scagliola Luisa Ricci Francesco Mainini Sabrina Di Marco Ivan Cuccovillo Anna Kajaste-Rudnitski David Sumpton Kevin M. Ryan Simone Cardaci
author_facet	Simone Torretta Alessandra Scagliola Luisa Ricci Francesco Mainini Sabrina Di Marco Ivan Cuccovillo Anna Kajaste-Rudnitski David Sumpton Kevin M. Ryan Simone Cardaci
author_sort	Simone Torretta
title	D-mannose suppresses macrophage IL-1β production
title_short	D-mannose suppresses macrophage IL-1β production
title_full	D-mannose suppresses macrophage IL-1β production
title_fullStr	D-mannose suppresses macrophage IL-1β production
title_full_unstemmed	D-mannose suppresses macrophage IL-1β production
title_sort	d-mannose suppresses macrophage il-1β production
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/33a11b42ec3643e18f2c5585a702657e
work_keys_str_mv	AT simonetorretta dmannosesuppressesmacrophageil1bproduction AT alessandrascagliola dmannosesuppressesmacrophageil1bproduction AT luisaricci dmannosesuppressesmacrophageil1bproduction AT francescomainini dmannosesuppressesmacrophageil1bproduction AT sabrinadimarco dmannosesuppressesmacrophageil1bproduction AT ivancuccovillo dmannosesuppressesmacrophageil1bproduction AT annakajasterudnitski dmannosesuppressesmacrophageil1bproduction AT davidsumpton dmannosesuppressesmacrophageil1bproduction AT kevinmryan dmannosesuppressesmacrophageil1bproduction AT simonecardaci dmannosesuppressesmacrophageil1bproduction
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D-mannose suppresses macrophage IL-1β production

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