Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study

Abstract Childhood maltreatment (CM) can increase the risk of adverse health consequences in adulthood. A deeper insight in underlying biological pathways would be of high clinical relevance for early detection and intervention. The untargeted investigation of all detectable metabolites and lipids i...

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Autores principales:	Alexandra M Koenig, Alexander Karabatsiakis, Thomas Stoll, Sarah Wilker, Thomas Hennessy, Michelle M Hill, Iris-Tatjana Kolassa
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/33a3f827ccf045a2b793b3156ae69c93
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spelling	oai:doaj.org-article:33a3f827ccf045a2b793b3156ae69c932021-12-02T15:08:14ZSerum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study10.1038/s41598-018-21763-62045-2322https://doaj.org/article/33a3f827ccf045a2b793b3156ae69c932018-02-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-21763-6https://doaj.org/toc/2045-2322Abstract Childhood maltreatment (CM) can increase the risk of adverse health consequences in adulthood. A deeper insight in underlying biological pathways would be of high clinical relevance for early detection and intervention. The untargeted investigation of all detectable metabolites and lipids in biological samples represents a promising new avenue to identify so far unknown biological pathways associated with CM. Using an untargeted approach, liquid chromatography-mass spectrometry (LC-MS) was performed on peripheral blood serum samples collected three months postpartum from 105 women with varying degrees of CM exposure. Comprehensive univariate and multivariate statistical analyses consistently identified eight biomarker candidates putatively belonging to antioxidant-, lipid-, and endocannabinoid-associated pathways, which differentiated between women with and without CM. Classification algorithms allowed for clear prediction of the CM status with high accuracy scores (~80–90%). Similar results were obtained when excluding all women with a lifetime psychiatric diagnosis. In order to confirm the identities of these promising biomarker candidates, LC-MS/MS analysis was applied, confirming one of the metabolites as bilirubin IXa, a potent antioxidant with immunomodulatory properties. In sum, our results suggest novel pathways that could explain long-term effects of CM on health and disease by influencing biological patterns associated with energy metabolism, inflammation, and oxidative stress.Alexandra M KoenigAlexander KarabatsiakisThomas StollSarah WilkerThomas HennessyMichelle M HillIris-Tatjana KolassaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Alexandra M Koenig Alexander Karabatsiakis Thomas Stoll Sarah Wilker Thomas Hennessy Michelle M Hill Iris-Tatjana Kolassa Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study
description	Abstract Childhood maltreatment (CM) can increase the risk of adverse health consequences in adulthood. A deeper insight in underlying biological pathways would be of high clinical relevance for early detection and intervention. The untargeted investigation of all detectable metabolites and lipids in biological samples represents a promising new avenue to identify so far unknown biological pathways associated with CM. Using an untargeted approach, liquid chromatography-mass spectrometry (LC-MS) was performed on peripheral blood serum samples collected three months postpartum from 105 women with varying degrees of CM exposure. Comprehensive univariate and multivariate statistical analyses consistently identified eight biomarker candidates putatively belonging to antioxidant-, lipid-, and endocannabinoid-associated pathways, which differentiated between women with and without CM. Classification algorithms allowed for clear prediction of the CM status with high accuracy scores (~80–90%). Similar results were obtained when excluding all women with a lifetime psychiatric diagnosis. In order to confirm the identities of these promising biomarker candidates, LC-MS/MS analysis was applied, confirming one of the metabolites as bilirubin IXa, a potent antioxidant with immunomodulatory properties. In sum, our results suggest novel pathways that could explain long-term effects of CM on health and disease by influencing biological patterns associated with energy metabolism, inflammation, and oxidative stress.
format	article
author	Alexandra M Koenig Alexander Karabatsiakis Thomas Stoll Sarah Wilker Thomas Hennessy Michelle M Hill Iris-Tatjana Kolassa
author_facet	Alexandra M Koenig Alexander Karabatsiakis Thomas Stoll Sarah Wilker Thomas Hennessy Michelle M Hill Iris-Tatjana Kolassa
author_sort	Alexandra M Koenig
title	Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study
title_short	Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study
title_full	Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study
title_fullStr	Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study
title_full_unstemmed	Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study
title_sort	serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/33a3f827ccf045a2b793b3156ae69c93
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Serum profile changes in postpartum women with a history of childhood maltreatment: a combined metabolite and lipid fingerprinting study

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