Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

The small molecule oridonin (Ori) from the traditional Chinese herb Rabdosia rubescens has anti-inflammatory activity. Here the authors show that Ori can be covalently linked to NLRP3 to prevent assembly of the NLRP3 inflammasome, and to ameliorate inflammation in several mouse disease models.

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Auteurs principaux:	Hongbin He, Hua Jiang, Yun Chen, Jin Ye, Aoli Wang, Chao Wang, Qingsong Liu, Gaolin Liang, Xianming Deng, Wei Jiang, Rongbin Zhou
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2018
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/33a471636355469c92084ba342e3fa48
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id	oai:doaj.org-article:33a471636355469c92084ba342e3fa48
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spelling	oai:doaj.org-article:33a471636355469c92084ba342e3fa482021-12-02T16:56:53ZOridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity10.1038/s41467-018-04947-62041-1723https://doaj.org/article/33a471636355469c92084ba342e3fa482018-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04947-6https://doaj.org/toc/2041-1723The small molecule oridonin (Ori) from the traditional Chinese herb Rabdosia rubescens has anti-inflammatory activity. Here the authors show that Ori can be covalently linked to NLRP3 to prevent assembly of the NLRP3 inflammasome, and to ameliorate inflammation in several mouse disease models.Hongbin HeHua JiangYun ChenJin YeAoli WangChao WangQingsong LiuGaolin LiangXianming DengWei JiangRongbin ZhouNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Hongbin He Hua Jiang Yun Chen Jin Ye Aoli Wang Chao Wang Qingsong Liu Gaolin Liang Xianming Deng Wei Jiang Rongbin Zhou Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
description	The small molecule oridonin (Ori) from the traditional Chinese herb Rabdosia rubescens has anti-inflammatory activity. Here the authors show that Ori can be covalently linked to NLRP3 to prevent assembly of the NLRP3 inflammasome, and to ameliorate inflammation in several mouse disease models.
format	article
author	Hongbin He Hua Jiang Yun Chen Jin Ye Aoli Wang Chao Wang Qingsong Liu Gaolin Liang Xianming Deng Wei Jiang Rongbin Zhou
author_facet	Hongbin He Hua Jiang Yun Chen Jin Ye Aoli Wang Chao Wang Qingsong Liu Gaolin Liang Xianming Deng Wei Jiang Rongbin Zhou
author_sort	Hongbin He
title	Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
title_short	Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
title_full	Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
title_fullStr	Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
title_full_unstemmed	Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity
title_sort	oridonin is a covalent nlrp3 inhibitor with strong anti-inflammasome activity
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/33a471636355469c92084ba342e3fa48
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Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

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