A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from nature

A combinatorial approach for the discovery of cytochrome P450 2D6 inhibitors from nature

Abstract The human cytochrome P450 2D6 (CYP2D6) enzyme is part of phase-I metabolism and metabolizes at least 20% of all clinically relevant drugs. Therefore, it is an important target for drug-drug interaction (DDI) studies. High-throughput screening (HTS) assays are commonly used tools to examine...

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Autores principales: Johannes Hochleitner, Muhammad Akram, Martina Ueberall, Rohan A. Davis, Birgit Waltenberger, Hermann Stuppner, Sonja Sturm, Florian Ueberall, Johanna M. Gostner, Daniela Schuster
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/33a551dcc5004dd0b9cac26fa715e9a5
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