PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

Protein kinase R (PKR) has been suggested to act as a mediator of ER stress and inflammation in obesity. Here, Lancaster et al. find that genetic loss of PKR does not alter the development of obesity, and suggest that the use of littermate controls may explain differences in mouse knockout phenotype...

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Autores principales:	G. I. Lancaster, H. L. Kammoun, M. J. Kraakman, G. M. Kowalski, C. R. Bruce, M. A. Febbraio
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33a5a266327947a0a8bd5841e6f42498
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spelling	oai:doaj.org-article:33a5a266327947a0a8bd5841e6f424982021-12-02T14:39:15ZPKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications10.1038/ncomms106262041-1723https://doaj.org/article/33a5a266327947a0a8bd5841e6f424982016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10626https://doaj.org/toc/2041-1723Protein kinase R (PKR) has been suggested to act as a mediator of ER stress and inflammation in obesity. Here, Lancaster et al. find that genetic loss of PKR does not alter the development of obesity, and suggest that the use of littermate controls may explain differences in mouse knockout phenotypes.G. I. LancasterH. L. KammounM. J. KraakmanG. M. KowalskiC. R. BruceM. A. FebbraioNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-10 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q G. I. Lancaster H. L. Kammoun M. J. Kraakman G. M. Kowalski C. R. Bruce M. A. Febbraio PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications
description	Protein kinase R (PKR) has been suggested to act as a mediator of ER stress and inflammation in obesity. Here, Lancaster et al. find that genetic loss of PKR does not alter the development of obesity, and suggest that the use of littermate controls may explain differences in mouse knockout phenotypes.
format	article
author	G. I. Lancaster H. L. Kammoun M. J. Kraakman G. M. Kowalski C. R. Bruce M. A. Febbraio
author_facet	G. I. Lancaster H. L. Kammoun M. J. Kraakman G. M. Kowalski C. R. Bruce M. A. Febbraio
author_sort	G. I. Lancaster
title	PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications
title_short	PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications
title_full	PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications
title_fullStr	PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications
title_full_unstemmed	PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications
title_sort	pkr is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/33a5a266327947a0a8bd5841e6f42498
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PKR is not obligatory for high-fat diet-induced obesity and its associated metabolic and inflammatory complications

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