The prognostic value of neutrophil-lymphocyte ratio in acute pancreatitis

Introduction and objective: Acute Pancreatitis (AP) is one of the leading causes of morbidity and mortality worldwide. In approximately a third of the patient with acute pancreatitis, severe pancreatitis may develop, producing progressive organ dysfunction caused by a systemic inflammatory response...

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Autores principales:	Binit Katuwal, Sushil Kumar Shilpakar
Formato:	article
Lenguaje:	EN
Publicado:	Society of Surgeons of Nepal 2016
Materias:	Acute Pancreatitis revised Atlanta classification Neutrophil Lymphocyte Ratio Surgery RD1-811
Acceso en línea:	https://doaj.org/article/33a6bc114961484095e1195a6076674c
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spelling	oai:doaj.org-article:33a6bc114961484095e1195a6076674c2021-12-05T19:16:40ZThe prognostic value of neutrophil-lymphocyte ratio in acute pancreatitis10.3126/jssn.v18i3.152901815-39842392-4772https://doaj.org/article/33a6bc114961484095e1195a6076674c2016-07-01T00:00:00Zhttps://www.nepjol.info/index.php/JSSN/article/view/15290https://doaj.org/toc/1815-3984https://doaj.org/toc/2392-4772 Introduction and objective: Acute Pancreatitis (AP) is one of the leading causes of morbidity and mortality worldwide. In approximately a third of the patient with acute pancreatitis, severe pancreatitis may develop, producing progressive organ dysfunction caused by a systemic inflammatory response syndrome (SIRS). This study aimed to determine the correlation between Neutrophil Lymphocyte Ratio (NLR) and the severity of AP. Materials and Methods: All patients admitted in the Surgical Ward of Tribhuvan University Teaching Hospital with the diagnosis of AP were studied prospectively over a period of one year from January 2014 to January 2015. Total leucocyte count (TLC), neutrophil count, lymphocyte count and neutrophil lymphocyte ratio (NLR) at admission was recorded for each patient. Modified Marshall Score was determined at admission and at 48 hours. Severity of acute pancreatitis as defined by revised Atlanta Classification 2012 was taken into account. Results: A total of 79 patients of AP were included in the study. Among them, 38 % were categorized as having severe AP according to the revised Atlanta classification. There was a weak positive correlation of NLR to severity of AP which was statistically significant. The mean NLR was high in higher severity grades of AP (p-value < 0.05). The cutoff NLR of 8.02 showed sensitivity of 60 %, specificity of 60.4 %, PPV of 48.6 % and NPV of 70.7 %. Conclusion: NLR may be useful as an easy and reliable prognostic marker for the severity and complications of acute pancreatitis. Binit KatuwalSushil Kumar ShilpakarSociety of Surgeons of NepalarticleAcute Pancreatitisrevised Atlanta classificationNeutrophil Lymphocyte RatioSurgeryRD1-811ENJournal of Society of Surgeons of Nepal, Vol 18, Iss 3 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Acute Pancreatitis revised Atlanta classification Neutrophil Lymphocyte Ratio Surgery RD1-811
spellingShingle	Acute Pancreatitis revised Atlanta classification Neutrophil Lymphocyte Ratio Surgery RD1-811 Binit Katuwal Sushil Kumar Shilpakar The prognostic value of neutrophil-lymphocyte ratio in acute pancreatitis
description	Introduction and objective: Acute Pancreatitis (AP) is one of the leading causes of morbidity and mortality worldwide. In approximately a third of the patient with acute pancreatitis, severe pancreatitis may develop, producing progressive organ dysfunction caused by a systemic inflammatory response syndrome (SIRS). This study aimed to determine the correlation between Neutrophil Lymphocyte Ratio (NLR) and the severity of AP. Materials and Methods: All patients admitted in the Surgical Ward of Tribhuvan University Teaching Hospital with the diagnosis of AP were studied prospectively over a period of one year from January 2014 to January 2015. Total leucocyte count (TLC), neutrophil count, lymphocyte count and neutrophil lymphocyte ratio (NLR) at admission was recorded for each patient. Modified Marshall Score was determined at admission and at 48 hours. Severity of acute pancreatitis as defined by revised Atlanta Classification 2012 was taken into account. Results: A total of 79 patients of AP were included in the study. Among them, 38 % were categorized as having severe AP according to the revised Atlanta classification. There was a weak positive correlation of NLR to severity of AP which was statistically significant. The mean NLR was high in higher severity grades of AP (p-value < 0.05). The cutoff NLR of 8.02 showed sensitivity of 60 %, specificity of 60.4 %, PPV of 48.6 % and NPV of 70.7 %. Conclusion: NLR may be useful as an easy and reliable prognostic marker for the severity and complications of acute pancreatitis.
format	article
author	Binit Katuwal Sushil Kumar Shilpakar
author_facet	Binit Katuwal Sushil Kumar Shilpakar
author_sort	Binit Katuwal
title	The prognostic value of neutrophil-lymphocyte ratio in acute pancreatitis
title_short	The prognostic value of neutrophil-lymphocyte ratio in acute pancreatitis
title_full	The prognostic value of neutrophil-lymphocyte ratio in acute pancreatitis
title_fullStr	The prognostic value of neutrophil-lymphocyte ratio in acute pancreatitis
title_full_unstemmed	The prognostic value of neutrophil-lymphocyte ratio in acute pancreatitis
title_sort	prognostic value of neutrophil-lymphocyte ratio in acute pancreatitis
publisher	Society of Surgeons of Nepal
publishDate	2016
url	https://doaj.org/article/33a6bc114961484095e1195a6076674c
work_keys_str_mv	AT binitkatuwal theprognosticvalueofneutrophillymphocyteratioinacutepancreatitis AT sushilkumarshilpakar theprognosticvalueofneutrophillymphocyteratioinacutepancreatitis AT binitkatuwal prognosticvalueofneutrophillymphocyteratioinacutepancreatitis AT sushilkumarshilpakar prognosticvalueofneutrophillymphocyteratioinacutepancreatitis
_version_	1718371054573846528

The prognostic value of neutrophil-lymphocyte ratio in acute pancreatitis

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