Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease?

Chronic kidney disease (CKD) is a progressive impairment of renal function for more than three months that affects 15% of the adult population. Because oxidative stress is involved in its pathogenesis, antioxidants are under study for the prophylaxis of CKD progression. The objective of this work wa...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Alfredo G. Casanova, Francisco J. López-Hernández, Laura Vicente-Vicente, Ana I. Morales
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	chronic kidney disease antioxidants meta-analysis bardoxolone methyl pentoxifylline nephroprotection Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/33a6e40a6104402bab1572765290fa73
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:33a6e40a6104402bab1572765290fa73
record_format	dspace
spelling	oai:doaj.org-article:33a6e40a6104402bab1572765290fa732021-11-25T16:25:44ZAre Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease?10.3390/antiox101116692076-3921https://doaj.org/article/33a6e40a6104402bab1572765290fa732021-10-01T00:00:00Zhttps://www.mdpi.com/2076-3921/10/11/1669https://doaj.org/toc/2076-3921Chronic kidney disease (CKD) is a progressive impairment of renal function for more than three months that affects 15% of the adult population. Because oxidative stress is involved in its pathogenesis, antioxidants are under study for the prophylaxis of CKD progression. The objective of this work was to meta-analyze the efficacy of antioxidant therapy in CKD patients and to identify the most effective candidate antioxidants. Our meta-analysis showed that, despite being quite heterogeneous, overall antioxidant therapy apparently reduced CKD progression. Pentoxifylline and bardoxolone methyl demonstrated a robust and statistically significant protection, while other products showed a favorable but non-significant tendency, due to a high interindividual variability. Off-target (i.e., antioxidant-independent) effects, such as body weight reduction and heart failure-associated blood dilution, might totally or partially explain the protection provided by effective antioxidants. This potential pleiotropy introduces uncertainty on the role of oxidative stress in CKD progression and on antioxidant therapy in its prevention, which needs to be further investigated. Independently, identification of factors determining the nephroprotective effect of each candidate on each patient is thus necessary for a prospectively personalized antioxidant therapy. Finally, pentoxifylline should be further explored for the prophylaxis of CKD progression.Alfredo G. CasanovaFrancisco J. López-HernándezLaura Vicente-VicenteAna I. MoralesMDPI AGarticlechronic kidney diseaseantioxidantsmeta-analysisbardoxolone methylpentoxifyllinenephroprotectionTherapeutics. PharmacologyRM1-950ENAntioxidants, Vol 10, Iss 1669, p 1669 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	chronic kidney disease antioxidants meta-analysis bardoxolone methyl pentoxifylline nephroprotection Therapeutics. Pharmacology RM1-950
spellingShingle	chronic kidney disease antioxidants meta-analysis bardoxolone methyl pentoxifylline nephroprotection Therapeutics. Pharmacology RM1-950 Alfredo G. Casanova Francisco J. López-Hernández Laura Vicente-Vicente Ana I. Morales Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease?
description	Chronic kidney disease (CKD) is a progressive impairment of renal function for more than three months that affects 15% of the adult population. Because oxidative stress is involved in its pathogenesis, antioxidants are under study for the prophylaxis of CKD progression. The objective of this work was to meta-analyze the efficacy of antioxidant therapy in CKD patients and to identify the most effective candidate antioxidants. Our meta-analysis showed that, despite being quite heterogeneous, overall antioxidant therapy apparently reduced CKD progression. Pentoxifylline and bardoxolone methyl demonstrated a robust and statistically significant protection, while other products showed a favorable but non-significant tendency, due to a high interindividual variability. Off-target (i.e., antioxidant-independent) effects, such as body weight reduction and heart failure-associated blood dilution, might totally or partially explain the protection provided by effective antioxidants. This potential pleiotropy introduces uncertainty on the role of oxidative stress in CKD progression and on antioxidant therapy in its prevention, which needs to be further investigated. Independently, identification of factors determining the nephroprotective effect of each candidate on each patient is thus necessary for a prospectively personalized antioxidant therapy. Finally, pentoxifylline should be further explored for the prophylaxis of CKD progression.
format	article
author	Alfredo G. Casanova Francisco J. López-Hernández Laura Vicente-Vicente Ana I. Morales
author_facet	Alfredo G. Casanova Francisco J. López-Hernández Laura Vicente-Vicente Ana I. Morales
author_sort	Alfredo G. Casanova
title	Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease?
title_short	Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease?
title_full	Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease?
title_fullStr	Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease?
title_full_unstemmed	Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease?
title_sort	are antioxidants useful in preventing the progression of chronic kidney disease?
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/33a6e40a6104402bab1572765290fa73
work_keys_str_mv	AT alfredogcasanova areantioxidantsusefulinpreventingtheprogressionofchronickidneydisease AT franciscojlopezhernandez areantioxidantsusefulinpreventingtheprogressionofchronickidneydisease AT lauravicentevicente areantioxidantsusefulinpreventingtheprogressionofchronickidneydisease AT anaimorales areantioxidantsusefulinpreventingtheprogressionofchronickidneydisease
_version_	1718413191977893888

Are Antioxidants Useful in Preventing the Progression of Chronic Kidney Disease?

Ejemplares similares