Accuracy of the Electronic Nose Breath Tests in Clinical Application: A Systematic Review and Meta-Analysis

(1) Background: An electronic nose applies a sensor array to detect volatile biomarkers in exhaled breath to diagnose diseases. The overall diagnostic accuracy remains unknown. The objective of this review was to provide an estimate of the diagnostic accuracy of sensor-based breath tests for the dia...

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Autores principales:	Hsiao-Yu Yang, Wan-Chin Chen, Rodger-Chen Tsai
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	volatile organic compound electronic nose sensors breath test breathomics Biotechnology TP248.13-248.65
Acceso en línea:	https://doaj.org/article/33a97dd54e1e45b0bbb37f9421370afc
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spelling	oai:doaj.org-article:33a97dd54e1e45b0bbb37f9421370afc2021-11-25T16:55:53ZAccuracy of the Electronic Nose Breath Tests in Clinical Application: A Systematic Review and Meta-Analysis10.3390/bios111104692079-6374https://doaj.org/article/33a97dd54e1e45b0bbb37f9421370afc2021-11-01T00:00:00Zhttps://www.mdpi.com/2079-6374/11/11/469https://doaj.org/toc/2079-6374(1) Background: An electronic nose applies a sensor array to detect volatile biomarkers in exhaled breath to diagnose diseases. The overall diagnostic accuracy remains unknown. The objective of this review was to provide an estimate of the diagnostic accuracy of sensor-based breath tests for the diagnosis of diseases. (2) Methods: We searched the PubMed and Web of Science databases for studies published between 1 January 2010 and 14 October 2021. The search was limited to human studies published in the English language. Clinical trials were not included in this review. (3) Results: Of the 2418 records identified, 44 publications were eligible, and 5728 patients were included in the final analyses. The pooled sensitivity was 90.0% (95% CI, 86.3–92.8%, I<sup>2</sup> = 47.7%), the specificity was 88.4% (95% CI, 87.1–89.5%, I<sup>2</sup> = 81.4%), and the pooled area under the curve was 0.93 (95% CI 0.91–0.95). (4) Conclusion: The findings of our review suggest that a standardized report of diagnostic accuracy and a report of the accuracy in a test set are needed. Sensor array systems of electronic noses have the potential for noninvasiveness at the point-of-care in hospitals. Nevertheless, the procedure for reporting the accuracy of a diagnostic test must be standardized.Hsiao-Yu YangWan-Chin ChenRodger-Chen TsaiMDPI AGarticlevolatile organic compoundelectronic nosesensorsbreath testbreathomicsBiotechnologyTP248.13-248.65ENBiosensors, Vol 11, Iss 469, p 469 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	volatile organic compound electronic nose sensors breath test breathomics Biotechnology TP248.13-248.65
spellingShingle	volatile organic compound electronic nose sensors breath test breathomics Biotechnology TP248.13-248.65 Hsiao-Yu Yang Wan-Chin Chen Rodger-Chen Tsai Accuracy of the Electronic Nose Breath Tests in Clinical Application: A Systematic Review and Meta-Analysis
description	(1) Background: An electronic nose applies a sensor array to detect volatile biomarkers in exhaled breath to diagnose diseases. The overall diagnostic accuracy remains unknown. The objective of this review was to provide an estimate of the diagnostic accuracy of sensor-based breath tests for the diagnosis of diseases. (2) Methods: We searched the PubMed and Web of Science databases for studies published between 1 January 2010 and 14 October 2021. The search was limited to human studies published in the English language. Clinical trials were not included in this review. (3) Results: Of the 2418 records identified, 44 publications were eligible, and 5728 patients were included in the final analyses. The pooled sensitivity was 90.0% (95% CI, 86.3–92.8%, I<sup>2</sup> = 47.7%), the specificity was 88.4% (95% CI, 87.1–89.5%, I<sup>2</sup> = 81.4%), and the pooled area under the curve was 0.93 (95% CI 0.91–0.95). (4) Conclusion: The findings of our review suggest that a standardized report of diagnostic accuracy and a report of the accuracy in a test set are needed. Sensor array systems of electronic noses have the potential for noninvasiveness at the point-of-care in hospitals. Nevertheless, the procedure for reporting the accuracy of a diagnostic test must be standardized.
format	article
author	Hsiao-Yu Yang Wan-Chin Chen Rodger-Chen Tsai
author_facet	Hsiao-Yu Yang Wan-Chin Chen Rodger-Chen Tsai
author_sort	Hsiao-Yu Yang
title	Accuracy of the Electronic Nose Breath Tests in Clinical Application: A Systematic Review and Meta-Analysis
title_short	Accuracy of the Electronic Nose Breath Tests in Clinical Application: A Systematic Review and Meta-Analysis
title_full	Accuracy of the Electronic Nose Breath Tests in Clinical Application: A Systematic Review and Meta-Analysis
title_fullStr	Accuracy of the Electronic Nose Breath Tests in Clinical Application: A Systematic Review and Meta-Analysis
title_full_unstemmed	Accuracy of the Electronic Nose Breath Tests in Clinical Application: A Systematic Review and Meta-Analysis
title_sort	accuracy of the electronic nose breath tests in clinical application: a systematic review and meta-analysis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/33a97dd54e1e45b0bbb37f9421370afc
work_keys_str_mv	AT hsiaoyuyang accuracyoftheelectronicnosebreathtestsinclinicalapplicationasystematicreviewandmetaanalysis AT wanchinchen accuracyoftheelectronicnosebreathtestsinclinicalapplicationasystematicreviewandmetaanalysis AT rodgerchentsai accuracyoftheelectronicnosebreathtestsinclinicalapplicationasystematicreviewandmetaanalysis
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Accuracy of the Electronic Nose Breath Tests in Clinical Application: A Systematic Review and Meta-Analysis

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