Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report

Abstract Background The current case report presents acute hemorrhagic necrotizing encephalopathy (AHNE) as an example of a fatal complication, the etiology of which could be coronavirus disease 2019 (COVID-19) with multiple organ damage along with the existing respiratory tuberculosis. Case present...

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Autores principales:	Victor Vladimirovich Ermilov, Nikita Alexeevich Dorofeev
Formato:	article
Lenguaje:	EN
Publicado:	SpringerOpen 2021
Materias:	SARS-CoV-2 Acute hemorrhagic necrotizing encephalopathy Endothelial dysfunction Endotheliitis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Acceso en línea:	https://doaj.org/article/33ab694c15ba484084c84ccb24f102a4
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spelling	oai:doaj.org-article:33ab694c15ba484084c84ccb24f102a42021-11-28T12:13:41ZClinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report10.1186/s41983-021-00413-11687-8329https://doaj.org/article/33ab694c15ba484084c84ccb24f102a42021-11-01T00:00:00Zhttps://doi.org/10.1186/s41983-021-00413-1https://doaj.org/toc/1687-8329Abstract Background The current case report presents acute hemorrhagic necrotizing encephalopathy (AHNE) as an example of a fatal complication, the etiology of which could be coronavirus disease 2019 (COVID-19) with multiple organ damage along with the existing respiratory tuberculosis. Case presentation A male in his 20s had severe symptoms of central nervous system lesion, which developed against the background of COVID-19 and respiratory tuberculosis, for which he was treated in the intensive care unit. Autopsy confirmed that he died from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated AHNE in adults with severe fatal endothelial dysfunction and respiratory tuberculosis. The main morphological signs of brain damage were desquamative endotheliitis, thrombosis, parenchymal hemorrhagic necrosis, encephalitis, severe necrobiotic neuronal damage. Conclusion The defeat of endothelial cells with the development of generalized endotheliitis in COVID-19, especially in conjunction with comorbid pathology, in particular tuberculosis, can lead to a fatal complication that affects the nervous system—AHNE. Therefore, it is worth paying close attention to the appearance of neurological symptoms in patients with a similar combination of diseases.Victor Vladimirovich ErmilovNikita Alexeevich DorofeevSpringerOpenarticleSARS-CoV-2Acute hemorrhagic necrotizing encephalopathyEndothelial dysfunctionEndotheliitisNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571ENThe Egyptian Journal of Neurology, Psychiatry and Neurosurgery, Vol 57, Iss 1, Pp 1-4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 Acute hemorrhagic necrotizing encephalopathy Endothelial dysfunction Endotheliitis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
spellingShingle	SARS-CoV-2 Acute hemorrhagic necrotizing encephalopathy Endothelial dysfunction Endotheliitis Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Victor Vladimirovich Ermilov Nikita Alexeevich Dorofeev Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report
description	Abstract Background The current case report presents acute hemorrhagic necrotizing encephalopathy (AHNE) as an example of a fatal complication, the etiology of which could be coronavirus disease 2019 (COVID-19) with multiple organ damage along with the existing respiratory tuberculosis. Case presentation A male in his 20s had severe symptoms of central nervous system lesion, which developed against the background of COVID-19 and respiratory tuberculosis, for which he was treated in the intensive care unit. Autopsy confirmed that he died from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) associated AHNE in adults with severe fatal endothelial dysfunction and respiratory tuberculosis. The main morphological signs of brain damage were desquamative endotheliitis, thrombosis, parenchymal hemorrhagic necrosis, encephalitis, severe necrobiotic neuronal damage. Conclusion The defeat of endothelial cells with the development of generalized endotheliitis in COVID-19, especially in conjunction with comorbid pathology, in particular tuberculosis, can lead to a fatal complication that affects the nervous system—AHNE. Therefore, it is worth paying close attention to the appearance of neurological symptoms in patients with a similar combination of diseases.
format	article
author	Victor Vladimirovich Ermilov Nikita Alexeevich Dorofeev
author_facet	Victor Vladimirovich Ermilov Nikita Alexeevich Dorofeev
author_sort	Victor Vladimirovich Ermilov
title	Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report
title_short	Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report
title_full	Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report
title_fullStr	Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report
title_full_unstemmed	Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report
title_sort	clinical and morphological features of sars-cov-2 associated acute hemorrhagic necrotizing encephalopathy: case report
publisher	SpringerOpen
publishDate	2021
url	https://doaj.org/article/33ab694c15ba484084c84ccb24f102a4
work_keys_str_mv	AT victorvladimirovichermilov clinicalandmorphologicalfeaturesofsarscov2associatedacutehemorrhagicnecrotizingencephalopathycasereport AT nikitaalexeevichdorofeev clinicalandmorphologicalfeaturesofsarscov2associatedacutehemorrhagicnecrotizingencephalopathycasereport
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Clinical and morphological features of SARS-COV-2 associated acute hemorrhagic necrotizing encephalopathy: case report

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