B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation

DNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differentiation and the development of humoral immunity.

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Autores principales:	Benjamin G. Barwick, Christopher D. Scharer, Ryan J. Martinez, Madeline J. Price, Alexander N. Wein, Robert R. Haines, Alexander P. R. Bally, Jacob E. Kohlmeier, Jeremy M. Boss
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33af14121bb04d5cbdd45624b424b0e7
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spelling	oai:doaj.org-article:33af14121bb04d5cbdd45624b424b0e72021-12-02T16:49:55ZB cell activation and plasma cell differentiation are inhibited by de novo DNA methylation10.1038/s41467-018-04234-42041-1723https://doaj.org/article/33af14121bb04d5cbdd45624b424b0e72018-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-04234-4https://doaj.org/toc/2041-1723DNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differentiation and the development of humoral immunity.Benjamin G. BarwickChristopher D. ScharerRyan J. MartinezMadeline J. PriceAlexander N. WeinRobert R. HainesAlexander P. R. BallyJacob E. KohlmeierJeremy M. BossNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Benjamin G. Barwick Christopher D. Scharer Ryan J. Martinez Madeline J. Price Alexander N. Wein Robert R. Haines Alexander P. R. Bally Jacob E. Kohlmeier Jeremy M. Boss B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
description	DNA methylation is known to contribute to B cell differentiation, but de novo methylation has not been studied in this context. Here the authors use a conditional Dnmt3a/b knockout mouse to map the function of de novo DNA methylation in B cell differentiation and the development of humoral immunity.
format	article
author	Benjamin G. Barwick Christopher D. Scharer Ryan J. Martinez Madeline J. Price Alexander N. Wein Robert R. Haines Alexander P. R. Bally Jacob E. Kohlmeier Jeremy M. Boss
author_facet	Benjamin G. Barwick Christopher D. Scharer Ryan J. Martinez Madeline J. Price Alexander N. Wein Robert R. Haines Alexander P. R. Bally Jacob E. Kohlmeier Jeremy M. Boss
author_sort	Benjamin G. Barwick
title	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
title_short	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
title_full	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
title_fullStr	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
title_full_unstemmed	B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation
title_sort	b cell activation and plasma cell differentiation are inhibited by de novo dna methylation
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/33af14121bb04d5cbdd45624b424b0e7
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B cell activation and plasma cell differentiation are inhibited by de novo DNA methylation

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