Detecting Cognitive Impairment in Idiopathic Intracranial Hypertension Using Ocular Motor and Neuropsychological Testing

Objective: To determine whether cognitive impairments in patients with Idiopathic Intracranial Hypertension (IIH) are correlated with changes in visual processing, weight, waist circumference, mood or headache, and whether they change over time.Methods: Twenty-two newly diagnosed IIH patients partic...

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Autores principales:	Wendy Wang, Meaghan Clough, Owen White, Neil Shuey, Anneke Van Der Walt, Joanne Fielding
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	idiopathic intracranial hypertension cognitive impairments ocular motor neuropsychology inhibitory control visual processing Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/33afaa6cc7d146979e3070894f486ba0
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spelling	oai:doaj.org-article:33afaa6cc7d146979e3070894f486ba02021-11-16T06:17:28ZDetecting Cognitive Impairment in Idiopathic Intracranial Hypertension Using Ocular Motor and Neuropsychological Testing1664-229510.3389/fneur.2021.772513https://doaj.org/article/33afaa6cc7d146979e3070894f486ba02021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fneur.2021.772513/fullhttps://doaj.org/toc/1664-2295Objective: To determine whether cognitive impairments in patients with Idiopathic Intracranial Hypertension (IIH) are correlated with changes in visual processing, weight, waist circumference, mood or headache, and whether they change over time.Methods: Twenty-two newly diagnosed IIH patients participated, with a subset assessed longitudinally at 3 and 6 months. Both conventional and novel ocular motor tests of cognition were included: Symbol Digit Modalities Test (SDMT), Stroop Colour and Word Test (SCWT), Digit Span, California Verbal Learning Test (CVLT), prosaccade (PS) task, antisaccade (AS) task, interleaved antisaccade-prosaccade (AS-PS) task. Patients also completed headache, mood, and visual functioning questionnaires.Results: IIH patients performed more poorly than controls on the SDMT (p< 0.001), SCWT (p = 0.021), Digit Span test (p< 0.001) and CVLT (p = 0.004) at baseline, and generated a higher proportion of AS errors in both the AS (p< 0.001) and AS-PS tasks (p = 0.007). Further, IIH patients exhibited prolonged latencies on the cognitively complex AS-PS task (p = 0.034). While weight, waist circumference, headache and mood did not predict performance on any experimental measure, increased retinal nerve fibre layer (RNFL) was associated with AS error rate on both the block [F(3, 19)=3.22, B = 0.30, p = 0.022] and AS-PS task [F(3, 20) = 2.65, B = 0.363, p = 0.013]. Unlike ocular motor changes, impairments revealed on conventional tests of cognition persisted up to 6 months.Conclusion: We found multi-domain cognitive impairments in IIH patients that were unrelated to clinical characteristics. Marked ocular motor inhibitory control deficits were predicted by RNFL thickness but remained distinct from other cognitive changes, underscoring the significance of visual processing changes in IIH.Wendy WangWendy WangMeaghan CloughOwen WhiteOwen WhiteNeil ShueyAnneke Van Der WaltAnneke Van Der WaltJoanne FieldingFrontiers Media S.A.articleidiopathic intracranial hypertensioncognitive impairmentsocular motorneuropsychologyinhibitory controlvisual processingNeurology. Diseases of the nervous systemRC346-429ENFrontiers in Neurology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	idiopathic intracranial hypertension cognitive impairments ocular motor neuropsychology inhibitory control visual processing Neurology. Diseases of the nervous system RC346-429
spellingShingle	idiopathic intracranial hypertension cognitive impairments ocular motor neuropsychology inhibitory control visual processing Neurology. Diseases of the nervous system RC346-429 Wendy Wang Wendy Wang Meaghan Clough Owen White Owen White Neil Shuey Anneke Van Der Walt Anneke Van Der Walt Joanne Fielding Detecting Cognitive Impairment in Idiopathic Intracranial Hypertension Using Ocular Motor and Neuropsychological Testing
description	Objective: To determine whether cognitive impairments in patients with Idiopathic Intracranial Hypertension (IIH) are correlated with changes in visual processing, weight, waist circumference, mood or headache, and whether they change over time.Methods: Twenty-two newly diagnosed IIH patients participated, with a subset assessed longitudinally at 3 and 6 months. Both conventional and novel ocular motor tests of cognition were included: Symbol Digit Modalities Test (SDMT), Stroop Colour and Word Test (SCWT), Digit Span, California Verbal Learning Test (CVLT), prosaccade (PS) task, antisaccade (AS) task, interleaved antisaccade-prosaccade (AS-PS) task. Patients also completed headache, mood, and visual functioning questionnaires.Results: IIH patients performed more poorly than controls on the SDMT (p< 0.001), SCWT (p = 0.021), Digit Span test (p< 0.001) and CVLT (p = 0.004) at baseline, and generated a higher proportion of AS errors in both the AS (p< 0.001) and AS-PS tasks (p = 0.007). Further, IIH patients exhibited prolonged latencies on the cognitively complex AS-PS task (p = 0.034). While weight, waist circumference, headache and mood did not predict performance on any experimental measure, increased retinal nerve fibre layer (RNFL) was associated with AS error rate on both the block [F(3, 19)=3.22, B = 0.30, p = 0.022] and AS-PS task [F(3, 20) = 2.65, B = 0.363, p = 0.013]. Unlike ocular motor changes, impairments revealed on conventional tests of cognition persisted up to 6 months.Conclusion: We found multi-domain cognitive impairments in IIH patients that were unrelated to clinical characteristics. Marked ocular motor inhibitory control deficits were predicted by RNFL thickness but remained distinct from other cognitive changes, underscoring the significance of visual processing changes in IIH.
format	article
author	Wendy Wang Wendy Wang Meaghan Clough Owen White Owen White Neil Shuey Anneke Van Der Walt Anneke Van Der Walt Joanne Fielding
author_facet	Wendy Wang Wendy Wang Meaghan Clough Owen White Owen White Neil Shuey Anneke Van Der Walt Anneke Van Der Walt Joanne Fielding
author_sort	Wendy Wang
title	Detecting Cognitive Impairment in Idiopathic Intracranial Hypertension Using Ocular Motor and Neuropsychological Testing
title_short	Detecting Cognitive Impairment in Idiopathic Intracranial Hypertension Using Ocular Motor and Neuropsychological Testing
title_full	Detecting Cognitive Impairment in Idiopathic Intracranial Hypertension Using Ocular Motor and Neuropsychological Testing
title_fullStr	Detecting Cognitive Impairment in Idiopathic Intracranial Hypertension Using Ocular Motor and Neuropsychological Testing
title_full_unstemmed	Detecting Cognitive Impairment in Idiopathic Intracranial Hypertension Using Ocular Motor and Neuropsychological Testing
title_sort	detecting cognitive impairment in idiopathic intracranial hypertension using ocular motor and neuropsychological testing
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/33afaa6cc7d146979e3070894f486ba0
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Detecting Cognitive Impairment in Idiopathic Intracranial Hypertension Using Ocular Motor and Neuropsychological Testing

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