IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS

Abstract. Present study concerned in vitro modifying effects of mevastatin, infliximab, r-met-Hu-sTNF-RI and IL-1ra upon antigen-induced activation of peripheral EBV-specific CD4+T-lymphocytes from the patients with rheumatoid arthritis (RA). When compared with healthy persons, the RA patients have...

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Autores principales:	I. V. Shirinsky, V. S. Shirinsky, C. A. Dinarello
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	rheumathoid arthritis epstein–barr virus treatment statins biological drugs Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/33b04b8675be44efab2fb398a6784976
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spelling	oai:doaj.org-article:33b04b8675be44efab2fb398a67849762021-11-18T08:03:42ZIN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS1563-06252313-741X10.15789/1563-0625-2011-2-3-285-290https://doaj.org/article/33b04b8675be44efab2fb398a67849762014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/528https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Present study concerned in vitro modifying effects of mevastatin, infliximab, r-met-Hu-sTNF-RI and IL-1ra upon antigen-induced activation of peripheral EBV-specific CD4+T-lymphocytes from the patients with rheumatoid arthritis (RA). When compared with healthy persons, the RA patients have shown significantly decreased concentrations of antigen-activated EBV-specific CD4+T-cells. In healthy donors, mevastatin, infliximab, r-met-Hu-sTNF-RI and IL-1ra did not influence the CD4+, IFNγ+ cell concentrations. Neither there were any effects of the abovementioned drugs upon the numbers of EBV-specific CD4+T-cell subset among cultured mononuclear cells from RA patients. Thus, the cells from RA patients exhibit a decreased in vitro antigen-induced activation of EBV-specific CD4+T-cells, whereas statins and biological agents do not promote suppression of EBV-specific activation of CD4+T-cells. (Med. Immunol., 2011, vol. 13, n 2-3, pp 285-290)I. V. ShirinskyV. S. ShirinskyC. A. DinarelloSPb RAACIarticlerheumathoid arthritisepstein–barr virustreatmentstatinsbiological drugsImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 13, Iss 2-3, Pp 285-290 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	rheumathoid arthritis epstein–barr virus treatment statins biological drugs Immunologic diseases. Allergy RC581-607
spellingShingle	rheumathoid arthritis epstein–barr virus treatment statins biological drugs Immunologic diseases. Allergy RC581-607 I. V. Shirinsky V. S. Shirinsky C. A. Dinarello IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
description	Abstract. Present study concerned in vitro modifying effects of mevastatin, infliximab, r-met-Hu-sTNF-RI and IL-1ra upon antigen-induced activation of peripheral EBV-specific CD4+T-lymphocytes from the patients with rheumatoid arthritis (RA). When compared with healthy persons, the RA patients have shown significantly decreased concentrations of antigen-activated EBV-specific CD4+T-cells. In healthy donors, mevastatin, infliximab, r-met-Hu-sTNF-RI and IL-1ra did not influence the CD4+, IFNγ+ cell concentrations. Neither there were any effects of the abovementioned drugs upon the numbers of EBV-specific CD4+T-cell subset among cultured mononuclear cells from RA patients. Thus, the cells from RA patients exhibit a decreased in vitro antigen-induced activation of EBV-specific CD4+T-cells, whereas statins and biological agents do not promote suppression of EBV-specific activation of CD4+T-cells. (Med. Immunol., 2011, vol. 13, n 2-3, pp 285-290)
format	article
author	I. V. Shirinsky V. S. Shirinsky C. A. Dinarello
author_facet	I. V. Shirinsky V. S. Shirinsky C. A. Dinarello
author_sort	I. V. Shirinsky
title	IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_short	IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_full	IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_fullStr	IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_full_unstemmed	IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS
title_sort	in vitro effects of mevastatin and biological preparations upon activation of ebv-specific cd4+t lymphocytes from the patients with rheumatoid arthritis
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/33b04b8675be44efab2fb398a6784976
work_keys_str_mv	AT ivshirinsky invitroeffectsofmevastatinandbiologicalpreparationsuponactivationofebvspecificcd4tlymphocytesfromthepatientswithrheumatoidarthritis AT vsshirinsky invitroeffectsofmevastatinandbiologicalpreparationsuponactivationofebvspecificcd4tlymphocytesfromthepatientswithrheumatoidarthritis AT cadinarello invitroeffectsofmevastatinandbiologicalpreparationsuponactivationofebvspecificcd4tlymphocytesfromthepatientswithrheumatoidarthritis
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IN VITRO EFFECTS OF MEVASTATIN AND BIOLOGICAL PREPARATIONS UPON ACTIVATION OF EBV-SPECIFIC CD4+T LYMPHOCYTES FROM THE PATIENTS WITH RHEUMATOID ARTHRITIS

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