Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study

Abstract This study evaluates the impact of breast cancer (BC) in health related quality of life (HRQL) and in psychological distress (PD) during the initial phases of the disease and looks for contributing factors. A multicentric case-control study, EpiGEICAM, was carried out. Incident BC cases and...

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Autores principales:	Nerea Fernández de Larrea-Baz, Beatriz Pérez-Gómez, Ángel Guerrero-Zotano, Ana María Casas, Begoña Bermejo, José Manuel Baena-Cañada, Silvia Antolin, Pedro Sánchez-Rovira, Manuel Ramos Vázquez, José Ángel Garcia-Sáenz, Antonio Antón, Montserrat Muñoz, Ana de Juan, Carlos Jara, José Ignacio Chacón, Angels Arcusa, Miguel Gil-Gil, Encarna Adrover, Amparo Oltra, Joan Brunet, Sonia González, Susana Bezares, Virginia Lope, Miguel Martín, Marina Pollán
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/33b3d22231de42aba2eaca043fcc939b
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spelling	oai:doaj.org-article:33b3d22231de42aba2eaca043fcc939b2021-12-02T14:49:43ZPrimary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study10.1038/s41598-020-63637-w2045-2322https://doaj.org/article/33b3d22231de42aba2eaca043fcc939b2020-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-020-63637-whttps://doaj.org/toc/2045-2322Abstract This study evaluates the impact of breast cancer (BC) in health related quality of life (HRQL) and in psychological distress (PD) during the initial phases of the disease and looks for contributing factors. A multicentric case-control study, EpiGEICAM, was carried out. Incident BC cases and age- and residence- matched controls were included. Clinical, epidemiological, HRQL (SF-36) and PD information (GHQ-28) was collected. We used multivariable logistic regression models to estimate OR of low HRQL and of PD in cases compared to controls, and to identify factors associated with low HRQL and with PD. Among 896 BC cases and 890 control women, cases had poorer scores than both, the reference population and the control group, in all SF-36 scales. BC women with lower education, younger, active workers, never smokers, those with comorbidities, in stage IV and with surgical treatment had lower physical HRQL; factors associated with low mental HRQL were dissatisfaction with social support, being current smoker and having children. Cases had a fivefold increased odds of PD compared to controls. Managing comorbidities and trying to promote social support, especially in younger and less educated women, could improve well-being of BC patients.Nerea Fernández de Larrea-BazBeatriz Pérez-GómezÁngel Guerrero-ZotanoAna María CasasBegoña BermejoJosé Manuel Baena-CañadaSilvia AntolinPedro Sánchez-RoviraManuel Ramos VázquezJosé Ángel Garcia-SáenzAntonio AntónMontserrat MuñozAna de JuanCarlos JaraJosé Ignacio ChacónAngels ArcusaMiguel Gil-GilEncarna AdroverAmparo OltraJoan BrunetSonia GonzálezSusana BezaresVirginia LopeMiguel MartínMarina PollánNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 10, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Nerea Fernández de Larrea-Baz Beatriz Pérez-Gómez Ángel Guerrero-Zotano Ana María Casas Begoña Bermejo José Manuel Baena-Cañada Silvia Antolin Pedro Sánchez-Rovira Manuel Ramos Vázquez José Ángel Garcia-Sáenz Antonio Antón Montserrat Muñoz Ana de Juan Carlos Jara José Ignacio Chacón Angels Arcusa Miguel Gil-Gil Encarna Adrover Amparo Oltra Joan Brunet Sonia González Susana Bezares Virginia Lope Miguel Martín Marina Pollán Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study
description	Abstract This study evaluates the impact of breast cancer (BC) in health related quality of life (HRQL) and in psychological distress (PD) during the initial phases of the disease and looks for contributing factors. A multicentric case-control study, EpiGEICAM, was carried out. Incident BC cases and age- and residence- matched controls were included. Clinical, epidemiological, HRQL (SF-36) and PD information (GHQ-28) was collected. We used multivariable logistic regression models to estimate OR of low HRQL and of PD in cases compared to controls, and to identify factors associated with low HRQL and with PD. Among 896 BC cases and 890 control women, cases had poorer scores than both, the reference population and the control group, in all SF-36 scales. BC women with lower education, younger, active workers, never smokers, those with comorbidities, in stage IV and with surgical treatment had lower physical HRQL; factors associated with low mental HRQL were dissatisfaction with social support, being current smoker and having children. Cases had a fivefold increased odds of PD compared to controls. Managing comorbidities and trying to promote social support, especially in younger and less educated women, could improve well-being of BC patients.
format	article
author	Nerea Fernández de Larrea-Baz Beatriz Pérez-Gómez Ángel Guerrero-Zotano Ana María Casas Begoña Bermejo José Manuel Baena-Cañada Silvia Antolin Pedro Sánchez-Rovira Manuel Ramos Vázquez José Ángel Garcia-Sáenz Antonio Antón Montserrat Muñoz Ana de Juan Carlos Jara José Ignacio Chacón Angels Arcusa Miguel Gil-Gil Encarna Adrover Amparo Oltra Joan Brunet Sonia González Susana Bezares Virginia Lope Miguel Martín Marina Pollán
author_facet	Nerea Fernández de Larrea-Baz Beatriz Pérez-Gómez Ángel Guerrero-Zotano Ana María Casas Begoña Bermejo José Manuel Baena-Cañada Silvia Antolin Pedro Sánchez-Rovira Manuel Ramos Vázquez José Ángel Garcia-Sáenz Antonio Antón Montserrat Muñoz Ana de Juan Carlos Jara José Ignacio Chacón Angels Arcusa Miguel Gil-Gil Encarna Adrover Amparo Oltra Joan Brunet Sonia González Susana Bezares Virginia Lope Miguel Martín Marina Pollán
author_sort	Nerea Fernández de Larrea-Baz
title	Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study
title_short	Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study
title_full	Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study
title_fullStr	Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study
title_full_unstemmed	Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study
title_sort	primary breast cancer and health related quality of life in spanish women: the epigeicam case-control study
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/33b3d22231de42aba2eaca043fcc939b
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Primary breast cancer and health related quality of life in Spanish women: The EpiGEICAM case-control study

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