EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1

Ando et al show in head and neck squamous cell carcinoma cells that EGFR activation leads to the phosphorylation of the Hippo pathway component, MOB1 to inhibit LATS1/2 function resulting in YAP/TAZ activation. Further, EGFR-targeting therapies suppress YAP/TAZ, and loss of LATS1/2-mediated YAP/TAZ...

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Autores principales:	Toshinori Ando, Nadia Arang, Zhiyong Wang, Daniela Elena Costea, Xiaodong Feng, Yusuke Goto, Hiroki Izumi, Mara Gilardi, Kazuyo Ando, J. Silvio Gutkind
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/33b5d7dcaf814e90908b2ebbb399a0ea
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spelling	oai:doaj.org-article:33b5d7dcaf814e90908b2ebbb399a0ea2021-11-07T12:20:40ZEGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB110.1038/s42003-021-02744-42399-3642https://doaj.org/article/33b5d7dcaf814e90908b2ebbb399a0ea2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02744-4https://doaj.org/toc/2399-3642Ando et al show in head and neck squamous cell carcinoma cells that EGFR activation leads to the phosphorylation of the Hippo pathway component, MOB1 to inhibit LATS1/2 function resulting in YAP/TAZ activation. Further, EGFR-targeting therapies suppress YAP/TAZ, and loss of LATS1/2-mediated YAP/TAZ activation confers therapy resistance, thus offering insights into potential drug resistance mechanisms in cancers with activated EGFR.Toshinori AndoNadia ArangZhiyong WangDaniela Elena CosteaXiaodong FengYusuke GotoHiroki IzumiMara GilardiKazuyo AndoJ. Silvio GutkindNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Toshinori Ando Nadia Arang Zhiyong Wang Daniela Elena Costea Xiaodong Feng Yusuke Goto Hiroki Izumi Mara Gilardi Kazuyo Ando J. Silvio Gutkind EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
description	Ando et al show in head and neck squamous cell carcinoma cells that EGFR activation leads to the phosphorylation of the Hippo pathway component, MOB1 to inhibit LATS1/2 function resulting in YAP/TAZ activation. Further, EGFR-targeting therapies suppress YAP/TAZ, and loss of LATS1/2-mediated YAP/TAZ activation confers therapy resistance, thus offering insights into potential drug resistance mechanisms in cancers with activated EGFR.
format	article
author	Toshinori Ando Nadia Arang Zhiyong Wang Daniela Elena Costea Xiaodong Feng Yusuke Goto Hiroki Izumi Mara Gilardi Kazuyo Ando J. Silvio Gutkind
author_facet	Toshinori Ando Nadia Arang Zhiyong Wang Daniela Elena Costea Xiaodong Feng Yusuke Goto Hiroki Izumi Mara Gilardi Kazuyo Ando J. Silvio Gutkind
author_sort	Toshinori Ando
title	EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
title_short	EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
title_full	EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
title_fullStr	EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
title_full_unstemmed	EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
title_sort	egfr regulates the hippo pathway by promoting the tyrosine phosphorylation of mob1
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/33b5d7dcaf814e90908b2ebbb399a0ea
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EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1

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