Quantitative modelling of amino acid transport and homeostasis in mammalian cells

Cytosolic amino acid concentrations are carefully maintained, but how homeostasis occurs is unclear. Here, the authors show that amino acid transporters primarily determine intracellular amino acid levels and develop a model that predicts a perturbation response similar to experimental data.

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Autores principales:	Gregory Gauthier-Coles, Jade Vennitti, Zhiduo Zhang, William C. Comb, Shuran Xing, Kiran Javed, Angelika Bröer, Stefan Bröer
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33b82f1c4d6d4f39ae9daaf65ccf7097
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spelling	oai:doaj.org-article:33b82f1c4d6d4f39ae9daaf65ccf70972021-12-02T14:54:28ZQuantitative modelling of amino acid transport and homeostasis in mammalian cells10.1038/s41467-021-25563-x2041-1723https://doaj.org/article/33b82f1c4d6d4f39ae9daaf65ccf70972021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25563-xhttps://doaj.org/toc/2041-1723Cytosolic amino acid concentrations are carefully maintained, but how homeostasis occurs is unclear. Here, the authors show that amino acid transporters primarily determine intracellular amino acid levels and develop a model that predicts a perturbation response similar to experimental data.Gregory Gauthier-ColesJade VennittiZhiduo ZhangWilliam C. CombShuran XingKiran JavedAngelika BröerStefan BröerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Gregory Gauthier-Coles Jade Vennitti Zhiduo Zhang William C. Comb Shuran Xing Kiran Javed Angelika Bröer Stefan Bröer Quantitative modelling of amino acid transport and homeostasis in mammalian cells
description	Cytosolic amino acid concentrations are carefully maintained, but how homeostasis occurs is unclear. Here, the authors show that amino acid transporters primarily determine intracellular amino acid levels and develop a model that predicts a perturbation response similar to experimental data.
format	article
author	Gregory Gauthier-Coles Jade Vennitti Zhiduo Zhang William C. Comb Shuran Xing Kiran Javed Angelika Bröer Stefan Bröer
author_facet	Gregory Gauthier-Coles Jade Vennitti Zhiduo Zhang William C. Comb Shuran Xing Kiran Javed Angelika Bröer Stefan Bröer
author_sort	Gregory Gauthier-Coles
title	Quantitative modelling of amino acid transport and homeostasis in mammalian cells
title_short	Quantitative modelling of amino acid transport and homeostasis in mammalian cells
title_full	Quantitative modelling of amino acid transport and homeostasis in mammalian cells
title_fullStr	Quantitative modelling of amino acid transport and homeostasis in mammalian cells
title_full_unstemmed	Quantitative modelling of amino acid transport and homeostasis in mammalian cells
title_sort	quantitative modelling of amino acid transport and homeostasis in mammalian cells
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/33b82f1c4d6d4f39ae9daaf65ccf7097
work_keys_str_mv	AT gregorygauthiercoles quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT jadevennitti quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT zhiduozhang quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT williamccomb quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT shuranxing quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT kiranjaved quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT angelikabroer quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT stefanbroer quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells
_version_	1718389375658622976

Quantitative modelling of amino acid transport and homeostasis in mammalian cells

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