Quantitative modelling of amino acid transport and homeostasis in mammalian cells
Cytosolic amino acid concentrations are carefully maintained, but how homeostasis occurs is unclear. Here, the authors show that amino acid transporters primarily determine intracellular amino acid levels and develop a model that predicts a perturbation response similar to experimental data.
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2021
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oai:doaj.org-article:33b82f1c4d6d4f39ae9daaf65ccf70972021-12-02T14:54:28ZQuantitative modelling of amino acid transport and homeostasis in mammalian cells10.1038/s41467-021-25563-x2041-1723https://doaj.org/article/33b82f1c4d6d4f39ae9daaf65ccf70972021-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25563-xhttps://doaj.org/toc/2041-1723Cytosolic amino acid concentrations are carefully maintained, but how homeostasis occurs is unclear. Here, the authors show that amino acid transporters primarily determine intracellular amino acid levels and develop a model that predicts a perturbation response similar to experimental data.Gregory Gauthier-ColesJade VennittiZhiduo ZhangWilliam C. CombShuran XingKiran JavedAngelika BröerStefan BröerNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-18 (2021) |
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Science Q Gregory Gauthier-Coles Jade Vennitti Zhiduo Zhang William C. Comb Shuran Xing Kiran Javed Angelika Bröer Stefan Bröer Quantitative modelling of amino acid transport and homeostasis in mammalian cells |
description |
Cytosolic amino acid concentrations are carefully maintained, but how homeostasis occurs is unclear. Here, the authors show that amino acid transporters primarily determine intracellular amino acid levels and develop a model that predicts a perturbation response similar to experimental data. |
format |
article |
author |
Gregory Gauthier-Coles Jade Vennitti Zhiduo Zhang William C. Comb Shuran Xing Kiran Javed Angelika Bröer Stefan Bröer |
author_facet |
Gregory Gauthier-Coles Jade Vennitti Zhiduo Zhang William C. Comb Shuran Xing Kiran Javed Angelika Bröer Stefan Bröer |
author_sort |
Gregory Gauthier-Coles |
title |
Quantitative modelling of amino acid transport and homeostasis in mammalian cells |
title_short |
Quantitative modelling of amino acid transport and homeostasis in mammalian cells |
title_full |
Quantitative modelling of amino acid transport and homeostasis in mammalian cells |
title_fullStr |
Quantitative modelling of amino acid transport and homeostasis in mammalian cells |
title_full_unstemmed |
Quantitative modelling of amino acid transport and homeostasis in mammalian cells |
title_sort |
quantitative modelling of amino acid transport and homeostasis in mammalian cells |
publisher |
Nature Portfolio |
publishDate |
2021 |
url |
https://doaj.org/article/33b82f1c4d6d4f39ae9daaf65ccf7097 |
work_keys_str_mv |
AT gregorygauthiercoles quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT jadevennitti quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT zhiduozhang quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT williamccomb quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT shuranxing quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT kiranjaved quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT angelikabroer quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells AT stefanbroer quantitativemodellingofaminoacidtransportandhomeostasisinmammaliancells |
_version_ |
1718389375658622976 |