Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time.

This study determined the association between respiratory symptoms and death from respiratory causes over a period of 45 years. In four cohorts of random samples of Norwegian populations with 103,881 participants, 43,731 persons had died per 31 December 2016. In total, 5,949 (14%) had died from resp...

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Autores principales:	Knut Stavem, Ane Johannessen, Rune Nielsen, Amund Gulsvik
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/33ba718508fc4ac283622aac8c81b486
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spelling	oai:doaj.org-article:33ba718508fc4ac283622aac8c81b4862021-12-02T20:16:16ZRespiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time.1932-620310.1371/journal.pone.0260416https://doaj.org/article/33ba718508fc4ac283622aac8c81b4862021-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0260416https://doaj.org/toc/1932-6203This study determined the association between respiratory symptoms and death from respiratory causes over a period of 45 years. In four cohorts of random samples of Norwegian populations with 103,881 participants, 43,731 persons had died per 31 December 2016. In total, 5,949 (14%) had died from respiratory diseases; 2,442 (41%) from lung cancer, 1,717 (29%) chronic obstructive pulmonary disease (COPD), 1,348 (23%) pneumonia, 119 (2%) asthma, 147 (2%) interstitial lung disease and 176 (3%) other pulmonary diseases. Compared with persons without respiratory symptoms the multivariable adjusted hazard ratio (HR) for lung cancer deaths increased with score of breathlessness on effort and cough and phlegm, being 2.6 (95% CI 2.1-3.2) for breathlessness score 3 and 2.1 (95% CI 1.7-2.5) for cough and phlegm score 5. The HR of COPD death was 6.4 (95% CI 5.4-7.7) for breathlessness score 3 and 3.0 (2.4-3.6) for cough and phlegm score 5. Attacks of breathlessness and wheeze score 2 had a HR of 1.6 (1.4-1.9) for COPD death. The risk of pneumonia deaths increased also with higher breathlessness on effort score, but not with higher cough and phlegm score, except for score 2 with HR 1.5 (1.2-1.8). In this study with >2.4 million person-years at risk, a positive association was observed between scores of respiratory symptoms and deaths due to COPD and lung cancer. Respiratory symptoms are thus important risk factors, which should be followed thoroughly by health care practitioners for the benefit of public health.Knut StavemAne JohannessenRune NielsenAmund GulsvikPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 16, Iss 11, p e0260416 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Knut Stavem Ane Johannessen Rune Nielsen Amund Gulsvik Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time.
description	This study determined the association between respiratory symptoms and death from respiratory causes over a period of 45 years. In four cohorts of random samples of Norwegian populations with 103,881 participants, 43,731 persons had died per 31 December 2016. In total, 5,949 (14%) had died from respiratory diseases; 2,442 (41%) from lung cancer, 1,717 (29%) chronic obstructive pulmonary disease (COPD), 1,348 (23%) pneumonia, 119 (2%) asthma, 147 (2%) interstitial lung disease and 176 (3%) other pulmonary diseases. Compared with persons without respiratory symptoms the multivariable adjusted hazard ratio (HR) for lung cancer deaths increased with score of breathlessness on effort and cough and phlegm, being 2.6 (95% CI 2.1-3.2) for breathlessness score 3 and 2.1 (95% CI 1.7-2.5) for cough and phlegm score 5. The HR of COPD death was 6.4 (95% CI 5.4-7.7) for breathlessness score 3 and 3.0 (2.4-3.6) for cough and phlegm score 5. Attacks of breathlessness and wheeze score 2 had a HR of 1.6 (1.4-1.9) for COPD death. The risk of pneumonia deaths increased also with higher breathlessness on effort score, but not with higher cough and phlegm score, except for score 2 with HR 1.5 (1.2-1.8). In this study with >2.4 million person-years at risk, a positive association was observed between scores of respiratory symptoms and deaths due to COPD and lung cancer. Respiratory symptoms are thus important risk factors, which should be followed thoroughly by health care practitioners for the benefit of public health.
format	article
author	Knut Stavem Ane Johannessen Rune Nielsen Amund Gulsvik
author_facet	Knut Stavem Ane Johannessen Rune Nielsen Amund Gulsvik
author_sort	Knut Stavem
title	Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time.
title_short	Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time.
title_full	Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time.
title_fullStr	Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time.
title_full_unstemmed	Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time.
title_sort	respiratory symptoms and respiratory deaths: a multi-cohort study with 45 years observation time.
publisher	Public Library of Science (PLoS)
publishDate	2021
url	https://doaj.org/article/33ba718508fc4ac283622aac8c81b486
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Respiratory symptoms and respiratory deaths: A multi-cohort study with 45 years observation time.

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