Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone

Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone

Bone development and vascularization are coupled events that share many molecular mechanisms. Here the authors identify osteoblast-secreted Cxcl9 as an inhibitory regulator of angiogenesis and osteogenesis, and show that mTORC1 signaling and STAT1 are critical upstream mediators of the cytokine expr...

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Autores principales: Bin Huang, Wenhao Wang, Qingchu Li, Zhenyu Wang, Bo Yan, Zhongmin Zhang, Liang Wang, Minjun Huang, Chunhong Jia, Jiansen Lu, Sichi Liu, Hongdong Chen, Mangmang Li, Daozhang Cai, Yu Jiang, Dadi Jin, Xiaochun Bai
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2016
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Acceso en línea:https://doaj.org/article/33be49679ece42319a31ac77ec864eec
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Sumario:Bone development and vascularization are coupled events that share many molecular mechanisms. Here the authors identify osteoblast-secreted Cxcl9 as an inhibitory regulator of angiogenesis and osteogenesis, and show that mTORC1 signaling and STAT1 are critical upstream mediators of the cytokine expression.

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