Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone

Bone development and vascularization are coupled events that share many molecular mechanisms. Here the authors identify osteoblast-secreted Cxcl9 as an inhibitory regulator of angiogenesis and osteogenesis, and show that mTORC1 signaling and STAT1 are critical upstream mediators of the cytokine expr...

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Autores principales:	Bin Huang, Wenhao Wang, Qingchu Li, Zhenyu Wang, Bo Yan, Zhongmin Zhang, Liang Wang, Minjun Huang, Chunhong Jia, Jiansen Lu, Sichi Liu, Hongdong Chen, Mangmang Li, Daozhang Cai, Yu Jiang, Dadi Jin, Xiaochun Bai
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/33be49679ece42319a31ac77ec864eec
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spelling	oai:doaj.org-article:33be49679ece42319a31ac77ec864eec2021-12-02T15:34:33ZOsteoblasts secrete Cxcl9 to regulate angiogenesis in bone10.1038/ncomms138852041-1723https://doaj.org/article/33be49679ece42319a31ac77ec864eec2016-12-01T00:00:00Zhttps://doi.org/10.1038/ncomms13885https://doaj.org/toc/2041-1723Bone development and vascularization are coupled events that share many molecular mechanisms. Here the authors identify osteoblast-secreted Cxcl9 as an inhibitory regulator of angiogenesis and osteogenesis, and show that mTORC1 signaling and STAT1 are critical upstream mediators of the cytokine expression.Bin HuangWenhao WangQingchu LiZhenyu WangBo YanZhongmin ZhangLiang WangMinjun HuangChunhong JiaJiansen LuSichi LiuHongdong ChenMangmang LiDaozhang CaiYu JiangDadi JinXiaochun BaiNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Bin Huang Wenhao Wang Qingchu Li Zhenyu Wang Bo Yan Zhongmin Zhang Liang Wang Minjun Huang Chunhong Jia Jiansen Lu Sichi Liu Hongdong Chen Mangmang Li Daozhang Cai Yu Jiang Dadi Jin Xiaochun Bai Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone
description	Bone development and vascularization are coupled events that share many molecular mechanisms. Here the authors identify osteoblast-secreted Cxcl9 as an inhibitory regulator of angiogenesis and osteogenesis, and show that mTORC1 signaling and STAT1 are critical upstream mediators of the cytokine expression.
format	article
author	Bin Huang Wenhao Wang Qingchu Li Zhenyu Wang Bo Yan Zhongmin Zhang Liang Wang Minjun Huang Chunhong Jia Jiansen Lu Sichi Liu Hongdong Chen Mangmang Li Daozhang Cai Yu Jiang Dadi Jin Xiaochun Bai
author_facet	Bin Huang Wenhao Wang Qingchu Li Zhenyu Wang Bo Yan Zhongmin Zhang Liang Wang Minjun Huang Chunhong Jia Jiansen Lu Sichi Liu Hongdong Chen Mangmang Li Daozhang Cai Yu Jiang Dadi Jin Xiaochun Bai
author_sort	Bin Huang
title	Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone
title_short	Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone
title_full	Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone
title_fullStr	Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone
title_full_unstemmed	Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone
title_sort	osteoblasts secrete cxcl9 to regulate angiogenesis in bone
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/33be49679ece42319a31ac77ec864eec
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Osteoblasts secrete Cxcl9 to regulate angiogenesis in bone

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