Polyclonal light chains in cerebrovascular disease

Patrizia Fiori1, Maria Giannetti Luigi2, Linda Iurato1, Carminantonio Tammaro3, Gigliola Esposito3, Antonio Monaco11Central Operative Unit of Neurology (Dir. A Monaco), 2Infantile Neuropsychiatry and Social Service (Dir. LM Giannetti), 3Laboratory (Dir. CA Tammaro), ASL AV, Civil Hospital of Ariano...

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Autores principales:	Patrizia Fiori, Maria Giannetti Luigi, Linda Iurato, et al
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2010
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/33c4d09d9299432e96a6e6264711905e
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spelling	oai:doaj.org-article:33c4d09d9299432e96a6e6264711905e2021-12-02T05:54:22ZPolyclonal light chains in cerebrovascular disease1176-63281178-2021https://doaj.org/article/33c4d09d9299432e96a6e6264711905e2010-08-01T00:00:00Zhttp://www.dovepress.com/polyclonal-light-chains-in-cerebrovascular-disease-a5099https://doaj.org/toc/1176-6328https://doaj.org/toc/1178-2021Patrizia Fiori1, Maria Giannetti Luigi2, Linda Iurato1, Carminantonio Tammaro3, Gigliola Esposito3, Antonio Monaco11Central Operative Unit of Neurology (Dir. A Monaco), 2Infantile Neuropsychiatry and Social Service (Dir. LM Giannetti), 3Laboratory (Dir. CA Tammaro), ASL AV, Civil Hospital of Ariano Irpino, University of Naples, ItalyAbstract: Altered membrane permeability is a hallmark of inflammation and ischemia with systemic spreading. Renal dysfunction is a risk factor for cardiovascular, cerebrovascular, and metabolic diseases. The aim of the present study was to assess proteinuria and urinary polyclonal light chains in acute stroke and chronic cerebrovascular disease compared with other neurologic diseases. Our results showed significantly increased levels of urinary polyclonal light chains in cerebrovascular disease compared with other neurologic diseases. The highest values of urinary polyclonal &kappa; chains were found in acute stroke compared with chronic cerebrovascular disease and other neurologic diseases, while the level of &lambda; chains was mainly increased in chronic cerebrovascular diseases. The shift to chronic renal failure seems to be signaled by a decreased polyclonal light chain/creatinemia ratio. The absence of a significant correlation with blood pressure and other seric parameters suggests that polyclonal light chains are an early marker of reversible vascular impairment with renal dysfunction before progression to irreversible renal failure and need for dialysis and/or intensive care.Keywords: polyclonal light chains, cerebrovascular disease, renal failure Patrizia FioriMaria Giannetti LuigiLinda Iuratoet alDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2010, Iss Issue 1, Pp 533-537 (2010)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Patrizia Fiori Maria Giannetti Luigi Linda Iurato et al Polyclonal light chains in cerebrovascular disease
description	Patrizia Fiori1, Maria Giannetti Luigi2, Linda Iurato1, Carminantonio Tammaro3, Gigliola Esposito3, Antonio Monaco11Central Operative Unit of Neurology (Dir. A Monaco), 2Infantile Neuropsychiatry and Social Service (Dir. LM Giannetti), 3Laboratory (Dir. CA Tammaro), ASL AV, Civil Hospital of Ariano Irpino, University of Naples, ItalyAbstract: Altered membrane permeability is a hallmark of inflammation and ischemia with systemic spreading. Renal dysfunction is a risk factor for cardiovascular, cerebrovascular, and metabolic diseases. The aim of the present study was to assess proteinuria and urinary polyclonal light chains in acute stroke and chronic cerebrovascular disease compared with other neurologic diseases. Our results showed significantly increased levels of urinary polyclonal light chains in cerebrovascular disease compared with other neurologic diseases. The highest values of urinary polyclonal &kappa; chains were found in acute stroke compared with chronic cerebrovascular disease and other neurologic diseases, while the level of &lambda; chains was mainly increased in chronic cerebrovascular diseases. The shift to chronic renal failure seems to be signaled by a decreased polyclonal light chain/creatinemia ratio. The absence of a significant correlation with blood pressure and other seric parameters suggests that polyclonal light chains are an early marker of reversible vascular impairment with renal dysfunction before progression to irreversible renal failure and need for dialysis and/or intensive care.Keywords: polyclonal light chains, cerebrovascular disease, renal failure
format	article
author	Patrizia Fiori Maria Giannetti Luigi Linda Iurato et al
author_facet	Patrizia Fiori Maria Giannetti Luigi Linda Iurato et al
author_sort	Patrizia Fiori
title	Polyclonal light chains in cerebrovascular disease
title_short	Polyclonal light chains in cerebrovascular disease
title_full	Polyclonal light chains in cerebrovascular disease
title_fullStr	Polyclonal light chains in cerebrovascular disease
title_full_unstemmed	Polyclonal light chains in cerebrovascular disease
title_sort	polyclonal light chains in cerebrovascular disease
publisher	Dove Medical Press
publishDate	2010
url	https://doaj.org/article/33c4d09d9299432e96a6e6264711905e
work_keys_str_mv	AT patriziafiori polyclonallightchainsincerebrovasculardisease AT mariagiannettiluigi polyclonallightchainsincerebrovasculardisease AT lindaiurato polyclonallightchainsincerebrovasculardisease AT etal polyclonallightchainsincerebrovasculardisease
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Polyclonal light chains in cerebrovascular disease

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