ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation

ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation

This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.

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Autores principales: Yan Gu, Yanrong Chen, Lai Wei, Shuang Wu, Kaicheng Shen, Chengxiang Liu, Yan Dong, Yang Zhao, Yue Zhang, Chi Zhang, Wenling Zheng, Jiangyi He, Yunlong Wang, Yifei Li, Xiaoxin Zhao, Hongwei Wang, Jun Tan, Liting Wang, Qi Zhou, Ganfeng Xie, Houjie Liang, Juanjuan Ou
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Science
Q
Acceso en línea:https://doaj.org/article/33c740cbfc424f82b51a157bae061d41
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spelling oai:doaj.org-article:33c740cbfc424f82b51a157bae061d412021-11-21T12:38:50ZABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation10.1038/s41467-021-26967-52041-1723https://doaj.org/article/33c740cbfc424f82b51a157bae061d412021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-26967-5https://doaj.org/toc/2041-1723This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.Yan GuYanrong ChenLai WeiShuang WuKaicheng ShenChengxiang LiuYan DongYang ZhaoYue ZhangChi ZhangWenling ZhengJiangyi HeYunlong WangYifei LiXiaoxin ZhaoHongwei WangJun TanLiting WangQi ZhouGanfeng XieHoujie LiangJuanjuan OuNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yan Gu
Yanrong Chen
Lai Wei
Shuang Wu
Kaicheng Shen
Chengxiang Liu
Yan Dong
Yang Zhao
Yue Zhang
Chi Zhang
Wenling Zheng
Jiangyi He
Yunlong Wang
Yifei Li
Xiaoxin Zhao
Hongwei Wang
Jun Tan
Liting Wang
Qi Zhou
Ganfeng Xie
Houjie Liang
Juanjuan Ou
ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation
description This study reveals an unrecognized role of ABHD5 in regulating colon cancer stemness via controlling YAP methylation and nuclear localization, further explaining the molecular mechanism through which ABHD5 functions as a tumour suppressor gene in colon cancer.
format article
author Yan Gu
Yanrong Chen
Lai Wei
Shuang Wu
Kaicheng Shen
Chengxiang Liu
Yan Dong
Yang Zhao
Yue Zhang
Chi Zhang
Wenling Zheng
Jiangyi He
Yunlong Wang
Yifei Li
Xiaoxin Zhao
Hongwei Wang
Jun Tan
Liting Wang
Qi Zhou
Ganfeng Xie
Houjie Liang
Juanjuan Ou
author_facet Yan Gu
Yanrong Chen
Lai Wei
Shuang Wu
Kaicheng Shen
Chengxiang Liu
Yan Dong
Yang Zhao
Yue Zhang
Chi Zhang
Wenling Zheng
Jiangyi He
Yunlong Wang
Yifei Li
Xiaoxin Zhao
Hongwei Wang
Jun Tan
Liting Wang
Qi Zhou
Ganfeng Xie
Houjie Liang
Juanjuan Ou
author_sort Yan Gu
title ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation
title_short ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation
title_full ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation
title_fullStr ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation
title_full_unstemmed ABHD5 inhibits YAP-induced c-Met overexpression and colon cancer cell stemness via suppressing YAP methylation
title_sort abhd5 inhibits yap-induced c-met overexpression and colon cancer cell stemness via suppressing yap methylation
publisher Nature Portfolio
publishDate 2021
url https://doaj.org/article/33c740cbfc424f82b51a157bae061d41
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