Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270

Yingxue Yang,1,2 Xiating Zhang,1,2 Yu Zhu,1,2 Yakang Dai,3 Ting Liu,3 Yuping Wang1,2 1Department of Neurology, Xuanwu Hospital, Capital Medical University, 2Beijing Key Laboratory of Neuromodulation, Beijing, People’s Republic of China; 3Suzhou Institute of Biomedical Engineering and Tech...

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Autores principales:	Yang Y, Zhang X, Zhu Y, Dai Y, Liu T, Wang Y
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2015
Materias:	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/33c758f2584c4c9c8536d49a8c0a6215
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spelling	oai:doaj.org-article:33c758f2584c4c9c8536d49a8c0a62152021-12-02T00:52:03ZCognitive impairment in generalized anxiety disorder revealed by event-related potential N2701178-2021https://doaj.org/article/33c758f2584c4c9c8536d49a8c0a62152015-06-01T00:00:00Zhttp://www.dovepress.com/cognitive-impairment-in-generalized-anxiety-disorder-revealed-by-event-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Yingxue Yang,1,2 Xiating Zhang,1,2 Yu Zhu,1,2 Yakang Dai,3 Ting Liu,3 Yuping Wang1,2 1Department of Neurology, Xuanwu Hospital, Capital Medical University, 2Beijing Key Laboratory of Neuromodulation, Beijing, People’s Republic of China; 3Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, People’s Republic of China Background: Cognitive function in anxiety disorders has been the subject of limited investigation, especially in generalized anxiety disorder (GAD). The purpose of this study was to investigate the cognitive function in subjects with GAD using mismatch-triggered negativity N270.Methods: Fifteen medication-free patients with a DSM-IV diagnosis of GAD, and 15 well-matched healthy controls performed a dual-feature delayed matching task while event-related potentials were recorded from their scalp.Results: The GAD group was characterized by the decreased N270 amplitude in the left hemisphere. The smaller N270 amplitude was associated with greater symptoms of anxiety and depression.Conclusion: Since N270 is thought to index cognitive function in different domains, including attention and memory, our results suggest that individuals with GAD have an impaired cognitive function, particularly in selective attention and working memory. These cognitive deficits may have clinical significance in subjects with GAD and should be considered in treatment planning. Keywords: generalized anxiety disorder, N270, cognitive function, selective attention, working memoryYang YZhang XZhu YDai YLiu TWang YDove Medical PressarticleNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol 2015, Iss default, Pp 1405-1411 (2015)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Yang Y Zhang X Zhu Y Dai Y Liu T Wang Y Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270
description	Yingxue Yang,1,2 Xiating Zhang,1,2 Yu Zhu,1,2 Yakang Dai,3 Ting Liu,3 Yuping Wang1,2 1Department of Neurology, Xuanwu Hospital, Capital Medical University, 2Beijing Key Laboratory of Neuromodulation, Beijing, People’s Republic of China; 3Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, People’s Republic of China Background: Cognitive function in anxiety disorders has been the subject of limited investigation, especially in generalized anxiety disorder (GAD). The purpose of this study was to investigate the cognitive function in subjects with GAD using mismatch-triggered negativity N270.Methods: Fifteen medication-free patients with a DSM-IV diagnosis of GAD, and 15 well-matched healthy controls performed a dual-feature delayed matching task while event-related potentials were recorded from their scalp.Results: The GAD group was characterized by the decreased N270 amplitude in the left hemisphere. The smaller N270 amplitude was associated with greater symptoms of anxiety and depression.Conclusion: Since N270 is thought to index cognitive function in different domains, including attention and memory, our results suggest that individuals with GAD have an impaired cognitive function, particularly in selective attention and working memory. These cognitive deficits may have clinical significance in subjects with GAD and should be considered in treatment planning. Keywords: generalized anxiety disorder, N270, cognitive function, selective attention, working memory
format	article
author	Yang Y Zhang X Zhu Y Dai Y Liu T Wang Y
author_facet	Yang Y Zhang X Zhu Y Dai Y Liu T Wang Y
author_sort	Yang Y
title	Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270
title_short	Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270
title_full	Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270
title_fullStr	Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270
title_full_unstemmed	Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270
title_sort	cognitive impairment in generalized anxiety disorder revealed by event-related potential n270
publisher	Dove Medical Press
publishDate	2015
url	https://doaj.org/article/33c758f2584c4c9c8536d49a8c0a6215
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Cognitive impairment in generalized anxiety disorder revealed by event-related potential N270

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