Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway

HHV-6B (human herpesvirus 6B) is well known to evade host antiviral responses and establish a lifelong latent infection. How HHV-6B evades RNA recognition is still poorly understood. Our results indicate that HHV-6 U26 plays a vital role in RLR/MAVS signaling pathway activity. Knockout of endogenou...

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Autores principales:	Xuefeng Jiang, Tian Tang, Jinfeng Guo, Yuhang Wang, Peipei Li, Xiangjun Chen, Lily Wang, Yiqun Wen, Junli Jia, Garbarino Emanuela, Benshun Hu, Shuhua Chen, Kun Yao, Linyun Li, Huaming Tang
Formato:	article
Lenguaje:	EN
Publicado:	American Society for Microbiology 2021
Materias:	Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/33ca0ba86c534d3286f2f21b18635283
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

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spelling	oai:doaj.org-article:33ca0ba86c534d3286f2f21b186352832021-11-03T18:15:37ZHuman Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway2161-21292150-751110.1128/mBio.03505-20https://doaj.org/article/33ca0ba86c534d3286f2f21b186352832021-02-01T00:00:00Zhttps://journals.asm.org/doi/10.1128/mBio.03505-20https://doaj.org/toc/2161-2129https://doaj.org/toc/2150-7511 HHV-6B (human herpesvirus 6B) is well known to evade host antiviral responses and establish a lifelong latent infection. How HHV-6B evades RNA recognition is still poorly understood. Our results indicate that HHV-6 U26 plays a vital role in RLR/MAVS signaling pathway activity. Knockout of endogenous MAVS could facilitate HHV-6B replication. The findings in this study could provide new insights into host-virus interactions and help develop a new therapy against HHV-6B infection.Xuefeng JiangTian TangJinfeng GuoYuhang WangPeipei LiXiangjun ChenLily WangYiqun WenJunli JiaGarbarino EmanuelaBenshun HuShuhua ChenKun YaoLinyun LiHuaming TangAmerican Society for MicrobiologyarticleMicrobiologyQR1-502ENmBio, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Microbiology QR1-502
spellingShingle	Microbiology QR1-502 Xuefeng Jiang Tian Tang Jinfeng Guo Yuhang Wang Peipei Li Xiangjun Chen Lily Wang Yiqun Wen Junli Jia Garbarino Emanuela Benshun Hu Shuhua Chen Kun Yao Linyun Li Huaming Tang Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway
description	HHV-6B (human herpesvirus 6B) is well known to evade host antiviral responses and establish a lifelong latent infection. How HHV-6B evades RNA recognition is still poorly understood. Our results indicate that HHV-6 U26 plays a vital role in RLR/MAVS signaling pathway activity. Knockout of endogenous MAVS could facilitate HHV-6B replication. The findings in this study could provide new insights into host-virus interactions and help develop a new therapy against HHV-6B infection.
format	article
author	Xuefeng Jiang Tian Tang Jinfeng Guo Yuhang Wang Peipei Li Xiangjun Chen Lily Wang Yiqun Wen Junli Jia Garbarino Emanuela Benshun Hu Shuhua Chen Kun Yao Linyun Li Huaming Tang
author_facet	Xuefeng Jiang Tian Tang Jinfeng Guo Yuhang Wang Peipei Li Xiangjun Chen Lily Wang Yiqun Wen Junli Jia Garbarino Emanuela Benshun Hu Shuhua Chen Kun Yao Linyun Li Huaming Tang
author_sort	Xuefeng Jiang
title	Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway
title_short	Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway
title_full	Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway
title_fullStr	Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway
title_full_unstemmed	Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway
title_sort	human herpesvirus 6b u26 inhibits the activation of the rlr/mavs signaling pathway
publisher	American Society for Microbiology
publishDate	2021
url	https://doaj.org/article/33ca0ba86c534d3286f2f21b18635283
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Human Herpesvirus 6B U26 Inhibits the Activation of the RLR/MAVS Signaling Pathway

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