Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria
Abstract Malaria has provided a major selective pressure and has modulated the genetic diversity of the human genome. The variants of the Duffy Antigen/Receptor for Chemokines (DARC) gene have probably been selected by malaria parasites, particularly the FY*O allele, which is fixed in sub-Saharan Af...
Guardado en:
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | article |
| Lenguaje: | EN |
| Publicado: |
Nature Portfolio
2018
|
| Materias: | |
| Acceso en línea: | https://doaj.org/article/33cfd9ed40a8459583acd20767c13c78 |
| Etiquetas: |
Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
|
| id |
oai:doaj.org-article:33cfd9ed40a8459583acd20767c13c78 |
|---|---|
| record_format |
dspace |
| spelling |
oai:doaj.org-article:33cfd9ed40a8459583acd20767c13c782021-12-02T15:08:35ZSusceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria10.1038/s41598-018-32254-z2045-2322https://doaj.org/article/33cfd9ed40a8459583acd20767c13c782018-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-018-32254-zhttps://doaj.org/toc/2045-2322Abstract Malaria has provided a major selective pressure and has modulated the genetic diversity of the human genome. The variants of the Duffy Antigen/Receptor for Chemokines (DARC) gene have probably been selected by malaria parasites, particularly the FY*O allele, which is fixed in sub-Saharan Africa and confers resistance to Plasmodium vivax infection. Here, we showed the influence of genomic ancestry on the distribution of DARC genotypes in a highly admixed Brazilian population and confirmed the decreased susceptibility of the FY*A/FY*O genotype to clinical P. vivax malaria. FY*B/FY*O individuals were associated with a greater risk of developing clinical malaria. A remarkable difference among DARC variants concerning the susceptibility to clinical malaria was more evident for individuals who were less exposed to malaria, as measured by the time of residence in the endemic area. Additionally, we found that DARC-negative and FY*A/FY*O individuals had a greater chance of acquiring high levels of antibodies against the 19-kDa C-terminal region of the P. vivax merozoite surface protein-1. Altogether, our results provide evidence that DARC polymorphisms modulate the susceptibility to clinical P. vivax malaria and influence the naturally-acquired humoral immune response to malaria blood antigens, which may interfere with the efficacy of a future vaccine against malaria.Flora Satiko KanoAracele Maria de SouzaLeticia de Menezes TorresMarcelo Azevedo CostaFlávia Alessandra Souza-SilvaBruno Antônio Marinho SanchezCor Jesus Fernandes FontesIrene Silva SoaresCristiana Ferreira Alves de BritoLuzia Helena CarvalhoTais Nobrega SousaNature PortfolioarticleDuffy Antigen Receptor For Chemokines (DARC)Vivax MalariaGenomic AncestryClinical MalariaAncestry Informative Markers (AIMs)MedicineRScienceQENScientific Reports, Vol 8, Iss 1, Pp 1-14 (2018) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Duffy Antigen Receptor For Chemokines (DARC) Vivax Malaria Genomic Ancestry Clinical Malaria Ancestry Informative Markers (AIMs) Medicine R Science Q |
| spellingShingle |
Duffy Antigen Receptor For Chemokines (DARC) Vivax Malaria Genomic Ancestry Clinical Malaria Ancestry Informative Markers (AIMs) Medicine R Science Q Flora Satiko Kano Aracele Maria de Souza Leticia de Menezes Torres Marcelo Azevedo Costa Flávia Alessandra Souza-Silva Bruno Antônio Marinho Sanchez Cor Jesus Fernandes Fontes Irene Silva Soares Cristiana Ferreira Alves de Brito Luzia Helena Carvalho Tais Nobrega Sousa Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria |
| description |
Abstract Malaria has provided a major selective pressure and has modulated the genetic diversity of the human genome. The variants of the Duffy Antigen/Receptor for Chemokines (DARC) gene have probably been selected by malaria parasites, particularly the FY*O allele, which is fixed in sub-Saharan Africa and confers resistance to Plasmodium vivax infection. Here, we showed the influence of genomic ancestry on the distribution of DARC genotypes in a highly admixed Brazilian population and confirmed the decreased susceptibility of the FY*A/FY*O genotype to clinical P. vivax malaria. FY*B/FY*O individuals were associated with a greater risk of developing clinical malaria. A remarkable difference among DARC variants concerning the susceptibility to clinical malaria was more evident for individuals who were less exposed to malaria, as measured by the time of residence in the endemic area. Additionally, we found that DARC-negative and FY*A/FY*O individuals had a greater chance of acquiring high levels of antibodies against the 19-kDa C-terminal region of the P. vivax merozoite surface protein-1. Altogether, our results provide evidence that DARC polymorphisms modulate the susceptibility to clinical P. vivax malaria and influence the naturally-acquired humoral immune response to malaria blood antigens, which may interfere with the efficacy of a future vaccine against malaria. |
| format |
article |
| author |
Flora Satiko Kano Aracele Maria de Souza Leticia de Menezes Torres Marcelo Azevedo Costa Flávia Alessandra Souza-Silva Bruno Antônio Marinho Sanchez Cor Jesus Fernandes Fontes Irene Silva Soares Cristiana Ferreira Alves de Brito Luzia Helena Carvalho Tais Nobrega Sousa |
| author_facet |
Flora Satiko Kano Aracele Maria de Souza Leticia de Menezes Torres Marcelo Azevedo Costa Flávia Alessandra Souza-Silva Bruno Antônio Marinho Sanchez Cor Jesus Fernandes Fontes Irene Silva Soares Cristiana Ferreira Alves de Brito Luzia Helena Carvalho Tais Nobrega Sousa |
| author_sort |
Flora Satiko Kano |
| title |
Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria |
| title_short |
Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria |
| title_full |
Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria |
| title_fullStr |
Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria |
| title_full_unstemmed |
Susceptibility to Plasmodium vivax malaria associated with DARC (Duffy antigen) polymorphisms is influenced by the time of exposure to malaria |
| title_sort |
susceptibility to plasmodium vivax malaria associated with darc (duffy antigen) polymorphisms is influenced by the time of exposure to malaria |
| publisher |
Nature Portfolio |
| publishDate |
2018 |
| url |
https://doaj.org/article/33cfd9ed40a8459583acd20767c13c78 |
| work_keys_str_mv |
AT florasatikokano susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria AT aracelemariadesouza susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria AT leticiademenezestorres susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria AT marceloazevedocosta susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria AT flaviaalessandrasouzasilva susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria AT brunoantoniomarinhosanchez susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria AT corjesusfernandesfontes susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria AT irenesilvasoares susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria AT cristianaferreiraalvesdebrito susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria AT luziahelenacarvalho susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria AT taisnobregasousa susceptibilitytoplasmodiumvivaxmalariaassociatedwithdarcduffyantigenpolymorphismsisinfluencedbythetimeofexposuretomalaria |
| _version_ |
1718388051673088000 |