Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RN...

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Autores principales: Sophie A. Valkenburg, Samuel M.S. Cheng, Asmaa Hachim, Malik Peiris, John Nicholls
Formato: article
Lenguaje:EN
Publicado: Centers for Disease Control and Prevention 2021
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Acceso en línea:https://doaj.org/article/33d483af54364b9b8169613a2ccb12cf
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Sumario:The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA copies declined by 48.2%.