Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RN...

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Autores principales:	Sophie A. Valkenburg, Samuel M.S. Cheng, Asmaa Hachim, Malik Peiris, John Nicholls
Formato:	article
Lenguaje:	EN
Publicado:	Centers for Disease Control and Prevention 2021
Materias:	SARS-CoV-2 infectious virus antigen RT-PCR K18 hACE2 mice TCID50 Medicine R Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/33d483af54364b9b8169613a2ccb12cf
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spelling	oai:doaj.org-article:33d483af54364b9b8169613a2ccb12cf2021-11-22T12:58:51ZPostmortem Stability of SARS-CoV-2 in Mouse Lung Tissue10.3201/eid2712.2116211080-60401080-6059https://doaj.org/article/33d483af54364b9b8169613a2ccb12cf2021-12-01T00:00:00Zhttps://wwwnc.cdc.gov/eid/article/27/12/21-1621_articlehttps://doaj.org/toc/1080-6040https://doaj.org/toc/1080-6059 The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA copies declined by 48.2%. Sophie A. ValkenburgSamuel M.S. ChengAsmaa HachimMalik PeirisJohn NichollsCenters for Disease Control and PreventionarticleSARS-CoV-2infectious virusantigenRT-PCRK18 hACE2 miceTCID50MedicineRInfectious and parasitic diseasesRC109-216ENEmerging Infectious Diseases, Vol 27, Iss 12, Pp 3173-3175 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	SARS-CoV-2 infectious virus antigen RT-PCR K18 hACE2 mice TCID50 Medicine R Infectious and parasitic diseases RC109-216
spellingShingle	SARS-CoV-2 infectious virus antigen RT-PCR K18 hACE2 mice TCID50 Medicine R Infectious and parasitic diseases RC109-216 Sophie A. Valkenburg Samuel M.S. Cheng Asmaa Hachim Malik Peiris John Nicholls Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
description	The infectivity of severe acute respiratory syndrome coronavirus 2 in deceased persons and organisms remains unclear. We studied transgenic K18 hACE2 mice to determine the kinetics of virus infectivity after host death. Five days after death, virus infectivity in the lung declined by >96% and RNA copies declined by 48.2%.
format	article
author	Sophie A. Valkenburg Samuel M.S. Cheng Asmaa Hachim Malik Peiris John Nicholls
author_facet	Sophie A. Valkenburg Samuel M.S. Cheng Asmaa Hachim Malik Peiris John Nicholls
author_sort	Sophie A. Valkenburg
title	Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title_short	Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title_full	Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title_fullStr	Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title_full_unstemmed	Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue
title_sort	postmortem stability of sars-cov-2 in mouse lung tissue
publisher	Centers for Disease Control and Prevention
publishDate	2021
url	https://doaj.org/article/33d483af54364b9b8169613a2ccb12cf
work_keys_str_mv	AT sophieavalkenburg postmortemstabilityofsarscov2inmouselungtissue AT samuelmscheng postmortemstabilityofsarscov2inmouselungtissue AT asmaahachim postmortemstabilityofsarscov2inmouselungtissue AT malikpeiris postmortemstabilityofsarscov2inmouselungtissue AT johnnicholls postmortemstabilityofsarscov2inmouselungtissue
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Postmortem Stability of SARS-CoV-2 in Mouse Lung Tissue

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