Construction of an HCC recurrence model basedon the investigation of immune-relatedlncRNAs and related mechanisms

Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in immune regulation. Growing evidence suggests that immune-related genes and lncRNAs can serve as markers to predict the prognosis of patients with cancers, including hepatocellular carci...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xiang-Xu Wang, Li-Hong Wu, Liping Ai, Wei Pan, Jing-Yi Ren, Qiong Zhang, Hong-Mei Zhang
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	hepatocellular carcinoma recurrence lncRNA immune microenvironment ceRNA Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/33d778e44f4c4536b45e072f06514a99
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:33d778e44f4c4536b45e072f06514a99
record_format	dspace
spelling	oai:doaj.org-article:33d778e44f4c4536b45e072f06514a992021-11-26T04:27:46ZConstruction of an HCC recurrence model basedon the investigation of immune-relatedlncRNAs and related mechanisms2162-253110.1016/j.omtn.2021.11.006https://doaj.org/article/33d778e44f4c4536b45e072f06514a992021-12-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S216225312100281Xhttps://doaj.org/toc/2162-2531Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in immune regulation. Growing evidence suggests that immune-related genes and lncRNAs can serve as markers to predict the prognosis of patients with cancers, including hepatocellular carcinoma (HCC). This study aimed to contract an immune-related lncRNA (IR-lncRNA) signature for prospective assessment to predict early recurrence of HCC. A total of 319 HCC samples under radical resection were randomly divided into a training cohort (161 samples) and a testing cohort (158 samples). In the training dataset, univariate, lasso, and multivariate Cox regression analyses identified a 9-IR-lncRNA signature closely related to disease-free survival. Kaplan-Meier analysis, principal component analysis, gene set enrichment analysis, and nomogram were used to evaluate the risk model. The results were further confirmed in the testing cohort. Furthermore, we constructed a competitive endogenous RNA regulatory network. The results of the present study indicated that this 9-IR-lncRNA signature has important clinical implications for improving predictive outcomes and guiding individualized treatment in HCC patients. These IR-lncRNAs and regulated genes may be potential biomarkers associated with the prognosis of HCC.Xiang-Xu WangLi-Hong WuLiping AiWei PanJing-Yi RenQiong ZhangHong-Mei ZhangElsevierarticlehepatocellular carcinomarecurrencelncRNAimmune microenvironmentceRNATherapeutics. PharmacologyRM1-950ENMolecular Therapy: Nucleic Acids, Vol 26, Iss , Pp 1387-1400 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	hepatocellular carcinoma recurrence lncRNA immune microenvironment ceRNA Therapeutics. Pharmacology RM1-950
spellingShingle	hepatocellular carcinoma recurrence lncRNA immune microenvironment ceRNA Therapeutics. Pharmacology RM1-950 Xiang-Xu Wang Li-Hong Wu Liping Ai Wei Pan Jing-Yi Ren Qiong Zhang Hong-Mei Zhang Construction of an HCC recurrence model basedon the investigation of immune-relatedlncRNAs and related mechanisms
description	Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression and play fundamental roles in immune regulation. Growing evidence suggests that immune-related genes and lncRNAs can serve as markers to predict the prognosis of patients with cancers, including hepatocellular carcinoma (HCC). This study aimed to contract an immune-related lncRNA (IR-lncRNA) signature for prospective assessment to predict early recurrence of HCC. A total of 319 HCC samples under radical resection were randomly divided into a training cohort (161 samples) and a testing cohort (158 samples). In the training dataset, univariate, lasso, and multivariate Cox regression analyses identified a 9-IR-lncRNA signature closely related to disease-free survival. Kaplan-Meier analysis, principal component analysis, gene set enrichment analysis, and nomogram were used to evaluate the risk model. The results were further confirmed in the testing cohort. Furthermore, we constructed a competitive endogenous RNA regulatory network. The results of the present study indicated that this 9-IR-lncRNA signature has important clinical implications for improving predictive outcomes and guiding individualized treatment in HCC patients. These IR-lncRNAs and regulated genes may be potential biomarkers associated with the prognosis of HCC.
format	article
author	Xiang-Xu Wang Li-Hong Wu Liping Ai Wei Pan Jing-Yi Ren Qiong Zhang Hong-Mei Zhang
author_facet	Xiang-Xu Wang Li-Hong Wu Liping Ai Wei Pan Jing-Yi Ren Qiong Zhang Hong-Mei Zhang
author_sort	Xiang-Xu Wang
title	Construction of an HCC recurrence model basedon the investigation of immune-relatedlncRNAs and related mechanisms
title_short	Construction of an HCC recurrence model basedon the investigation of immune-relatedlncRNAs and related mechanisms
title_full	Construction of an HCC recurrence model basedon the investigation of immune-relatedlncRNAs and related mechanisms
title_fullStr	Construction of an HCC recurrence model basedon the investigation of immune-relatedlncRNAs and related mechanisms
title_full_unstemmed	Construction of an HCC recurrence model basedon the investigation of immune-relatedlncRNAs and related mechanisms
title_sort	construction of an hcc recurrence model basedon the investigation of immune-relatedlncrnas and related mechanisms
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/33d778e44f4c4536b45e072f06514a99
work_keys_str_mv	AT xiangxuwang constructionofanhccrecurrencemodelbasedontheinvestigationofimmunerelatedlncrnasandrelatedmechanisms AT lihongwu constructionofanhccrecurrencemodelbasedontheinvestigationofimmunerelatedlncrnasandrelatedmechanisms AT lipingai constructionofanhccrecurrencemodelbasedontheinvestigationofimmunerelatedlncrnasandrelatedmechanisms AT weipan constructionofanhccrecurrencemodelbasedontheinvestigationofimmunerelatedlncrnasandrelatedmechanisms AT jingyiren constructionofanhccrecurrencemodelbasedontheinvestigationofimmunerelatedlncrnasandrelatedmechanisms AT qiongzhang constructionofanhccrecurrencemodelbasedontheinvestigationofimmunerelatedlncrnasandrelatedmechanisms AT hongmeizhang constructionofanhccrecurrencemodelbasedontheinvestigationofimmunerelatedlncrnasandrelatedmechanisms
_version_	1718409892757241856

Construction of an HCC recurrence model basedon the investigation of immune-relatedlncRNAs and related mechanisms

Ejemplares similares