A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC
APC is a well-known tumour suppressor that is frequently inactivated in colorectal cancer. Here, the authors sequence more than 1000 cancer genes in 468 colorectal cancers and show that mutation signatures can be used to classify the tumours and that multiple mutations in APCare associated with a po...
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Nature Portfolio
2016
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oai:doaj.org-article:33d97e94867e429f930222ed4bd1a79a2021-12-02T16:50:15ZA multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC10.1038/ncomms117432041-1723https://doaj.org/article/33d97e94867e429f930222ed4bd1a79a2016-06-01T00:00:00Zhttps://doi.org/10.1038/ncomms11743https://doaj.org/toc/2041-1723APC is a well-known tumour suppressor that is frequently inactivated in colorectal cancer. Here, the authors sequence more than 1000 cancer genes in 468 colorectal cancers and show that mutation signatures can be used to classify the tumours and that multiple mutations in APCare associated with a poor prognosis.Michael J. SchellMingli YangJamie K. TeerFang Yin LoAnup MadanDomenico CoppolaAlvaro N. A. MonteiroMichael V. NebozhynBinglin YueAndrey LobodaGabriel A. Bien-WillnerDanielle M. GreenawaltTimothy J. YeatmanNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016) |
| institution |
DOAJ |
| collection |
DOAJ |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Michael J. Schell Mingli Yang Jamie K. Teer Fang Yin Lo Anup Madan Domenico Coppola Alvaro N. A. Monteiro Michael V. Nebozhyn Binglin Yue Andrey Loboda Gabriel A. Bien-Willner Danielle M. Greenawalt Timothy J. Yeatman A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC |
| description |
APC is a well-known tumour suppressor that is frequently inactivated in colorectal cancer. Here, the authors sequence more than 1000 cancer genes in 468 colorectal cancers and show that mutation signatures can be used to classify the tumours and that multiple mutations in APCare associated with a poor prognosis. |
| format |
article |
| author |
Michael J. Schell Mingli Yang Jamie K. Teer Fang Yin Lo Anup Madan Domenico Coppola Alvaro N. A. Monteiro Michael V. Nebozhyn Binglin Yue Andrey Loboda Gabriel A. Bien-Willner Danielle M. Greenawalt Timothy J. Yeatman |
| author_facet |
Michael J. Schell Mingli Yang Jamie K. Teer Fang Yin Lo Anup Madan Domenico Coppola Alvaro N. A. Monteiro Michael V. Nebozhyn Binglin Yue Andrey Loboda Gabriel A. Bien-Willner Danielle M. Greenawalt Timothy J. Yeatman |
| author_sort |
Michael J. Schell |
| title |
A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC |
| title_short |
A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC |
| title_full |
A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC |
| title_fullStr |
A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC |
| title_full_unstemmed |
A multigene mutation classification of 468 colorectal cancers reveals a prognostic role for APC |
| title_sort |
multigene mutation classification of 468 colorectal cancers reveals a prognostic role for apc |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/33d97e94867e429f930222ed4bd1a79a |
| work_keys_str_mv |
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1718383029509947392 |